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Effectiveness of ADT therapy affected by presence of metastases

This is hardly a surprising piece of information, but it does at least confirm the expectable … A study published a couple of weeks ago in Cancer has shown that “factors predicting the efficacy of androgen deprivation therapy (ADT) in men with hormone-sensitive prostate cancer (HSPC) depend on whether or not metastases are present at the [...]

Enrollment in Cancer Trials

We say that we need clinical trials, but only a small percentage of patients actually enroll in these trials. We’ve known this for a while, but it has just been confirmed.
A study published in the Journal of Clinical Oncology shows that the overall enrollement in cancer trials hovers in the very low single digits. Men were [...]

Management of advanced prostate cancer: can we improve on androgen deprivation therapy?

An article with this title, just published in the British Journal of Urology, addresses the potential of the development-stage agent degarelix as a superior form of hormonal therapy compared to earlier LHRH (or GnRH) agonists.

Prostate Cancer in Cuba and Jamaica as Viewed from Turks and Caicos

 The Miami medical delegation has arrived in the Turks and Caicos Islands to join a peer-to-peer conference organized by Abbe Bendel and Dr. Mauricio Lynn of the Jackson Memorial Hospital International Program. (In the photo, Dr Kester Nedd and Dr Mauricio Lynn are ready to go.) The meeting was hosted by Dr. Rufus Ewing of the [...]

Prostate Cancer in the Caribbean

A discussion has unfolded on the Prostate Cancer InfoLink Caribbean Group forum. It has to do with the high mortality rates relative to incidence.
A question has been raised regarding stage at diagnosis, which, if late, can help to explain the ratio. Does anyone know where we can get good stage-at-diagnosis statistics for the Caribbean?
Click the image [...]

Aggressive Prostate Cancer After Dietary Supplements

I recently guest blogged on Respectful Insolence, a site loaded with ramblings from a fellow surgeon. The subject was two men with aggressive prostate cancer. Both had taken supplements.
This is a cautionary tale. Click here to read Death by Supplements

Adverse effects following 3D-CRT/IMRT for localized prostate cancer: 10-year follow-up

Zelefsky et al. have reported the incidence and predictors of treatment-related toxicities after three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for localized prostate cancer.

Predicting time to deferred treatment of patients on active surveillance

A study just published by van As et al. in the UK suggests the possible value of the free/total PSA ratio as a predictor of the time to deferred treatment in a well-defined group of untreated men with early stage, low grade disease being followed with active surveillance.

Selenium and prostate cancer prevention

The media suggest that certain supplements “may” prevent prostate cancer. Using such jargon as “anti-oxidant,” the pitch plays on our emotions as we seek to stay healthy. There’s just one problem: the suggestions are without basis. Let’s illustrate with the popular selenium as a proposed prostate cancer preventive.

Surgeon experience and prostate cancer surgery

Before you sign up for prostate cancer surgery, find out if your surgeon has enough of the right sort of experience. This may seem obvious, but many patients get distracted by institutional reputations, the latest gizmo the hospital is promoting, or where their neighbor had his operation. Don’t let yourself get distracted. Focus on what you want from [...]