Statins and prostate cancer: what’s the deal?

Yet again there is a lot of media noise about the possible impact of statins — drugs like simvastatin and Lipitor (atorvastatin) — on risk for prostate cancer. This time it results from a 15-year follow-up study of men at the Durham VA Medical Center in North Carolina.

The Halloween news for October 31, 2008

We have separately commented on a Swedish pilot study showing that men treated with captopril following radical prostatectomy had a  significant reduction in risk of biochemical recurrence. Other reports today deal with:

The potential of contrast enhanced eMRI in diagnosis and monitoring
Whether we can better identify high-risk patients with localized disease for curative surgery
Early-stage patients and risk [...]

Can captopril reduce rate of RP failures?

A potentially important Swedish pilot study has shown that men treated with the old cardiovascular drug captopril (Capoten) following radical prostatectomy had a very significant reduction in biochemical recurrence over an average follow-up of 29 months compared to untreated patients.

Thursday news update, Part B: October 30, 2008

Part B of today’s prostate cancer news update includes information about:

Screening behaviors of Afro-Caribbean men in Brooklyn, NY
Weight loss and prostate cancer risk
Potential of upgrading and upstaging of men with “favorable” prostate cancer on diagnosis
Effects of ADT on body lean and body fat mass
Salvage radiotherapy + androgen deprivation and toxic impact of treatment

Thursday news update, Part A: October 30, 2008

There’s a lot of news today, so we will break it into two sections for reading convenience. In Part A, we deal with information about:

Physicial activity and prostate cancer risk
Vasectomy and prostate cancer risk
The use of surveillance and watchful waiting in men in Sweden
A modification to Walsh’s nerve-sparing radical prostatectomy
The risks of “multimodal” therapy in [...]

New video-based prostate disease web site

We are pleased to hear that Dr. Gerald Chodak has now been able to complete his totally video-based prostate disease web service. This has been a considerable “labor of love” on Dr. Chodak’s part, but it will be an immensely valuable contribution to prostate cancer education for those who learn faster and better by “seeing and [...]

MDV3100 in castration-resistant prostate cancer

Medscape has just published an extensive update on the ongoing Phase I/II clinical trial of MDV3100 an investigational androgen-receptor antagonist for use in the treatment of advanced prostate cancer.

The Tuesday news update: October 28, 2008

Many reader will already have seen or heard reports of the demise of the SELECT prostate cancer prevention trial. In other news today:

There is a recent review of trials of diet and dietary supplements
Further evidence supports the potential of surrogate markers for prostate cancer mortality
Saturation biopsies appear to overestimate the risk of prostate cancer

SELECT Selenium Story

It was dramatic: a 63% reduction in prostate cancer incidence in men who took selenium pills. Everyone took notice. Everyone talked. And men took loads of selenium.

Neither selenium nor vitamin E supplements reduce risk for prostate cancer

Following an independent, initial review of the study data, the National Cancer Institute and the Southwest Oncology Group have stopped the 35,000-man SELECT study (Selenium and Vitamin E Cancer Prevention Trial). Apparently the supplements were not effective together or on their own in this four-arm trial.