ASCO commentary and update no. 3

There were probably over 100 posters related to prostate cancer presented at the ASCO meeting today (Sunday, May 31), so you will have to pardon us for not even attempting to report on all this vast variety of data. Rather, we have attempted to select out the papers that seem to offer the most interesting [...]

ASCO commentary and update no. 2

In this commentary we will discuss four additional, significant papers presented yesterday in the major oral session on new prostate cancer studies.

ASCO commentary and update no. 1

On Saturday there were two major prostate cancer sessions and additional poster sessions that included prostate cancer-related material at the annual meeting of the American Society for Clinical Oncology.

Metabolic syndrome, race, and risk for prostate cancer

Metabolic syndrome is increasingly prevalent in the USA and in other parts of the “westernized” world and consists of a cluster of conditions that are known risk factors for cardiovascular disease (obesity, high cholesterol levels, pre-diabetes, etc.). Several recent reports have also linked metabolic syndrome to prostate cancer — but have not had racially diverse [...]

Prostate cancer news reports: Friday, May 29, 2009

Today’s news reports address issues such as: Pro-PSA (a pecursor molecule to PSA itself) A review of development-stage markers for prostate cancer detection Understanding the pathology report A Phase I trial of high-dose testosterone in men with metatstatic CRPC

Prostate cancer news reports: Thursday, May 28, 2009

Today’s prostate cancer news reports address: A review of data on the potential for prostate cancer prevention A review of appropriate strategic options for rebiopsy in patients at risk Prostate cancer in men with a PSA < 2.5 ng/ml The sequential use of multiple cycles of docetaxel therapy

Cryotherapy for localized prostate cancer today: a cryotherapist’s opinion

Dr. Aaron Katz has been practicing cryotherapy at Columbia University Medical Center in New York since 1993, so one could reasonably expect him to have a sophisticated appreciation for the pros and cons of this technique.

Does an elevated melatonin level in morning urine really reduce risk for prostate cancer?

Every so often you come across something so far  “out of left field” that just possibly it may make some sense. So having said that, let me declare my ignorance.

Prostate cancer news reports: Wednesday, May 27, 2009

Today’s news reports cover such items as: Identification of prostate cancer cells in urine Prognosis after radiation therapy The effect of bisphenol A on prostate cancer therapy The appropriateness of primary androgen deprivation for localized prostate cancer Data from clinical trials of Phase II clinical trial of docetaxel + samarium-153 lexidronam and cyclophosphamide + dexamethasone [...]

More on the abiraterone acetate front

According to Phase I/II clinical trial data published on Wednesday in the on-line version of the Journal of Clinical Oncology, 9/24 subjects in one of the abiraterone prostate cancer studies demonstrated a decrease in tumor size. Maybe this helps to explain why Johnson & Johnson is willing to pay over $900 million for the company.

Keeping up to date with the screening controversy

Many readers may be interested in two articles on the “screening controversy” in the May issue of Oncology News International.

Prostate cancer news reports: Tuesday, May 26, 2009

In today’s news reports there are items on: Genetic modifications and prostate cancer risk and development Situation-specific prostate biopsy strategies A viral vector-prodrug combination in treatment of local and locally advanced disease Docetaxel + 153Sm lexidronam in metastatic CRPC

Controversy in the appropriate use of HIFU

Recently, a UK-based team (Challacombe et al.) working at a major London teaching hospital reported very poor 2-year follow-up data after treating a series of 31 newly diagnosed and 12 salvage patients with high-intensity focused ultrasound (HIFU) using second-generation Ablatherm equipment. They stated in their original paper that they had suspended their HIFU program as [...]

Overhaul of section on prostate cancer “Risk + Prevention”

We have taken advantage of the long weekend to carry out a complete overhaul of the major section on prostate cancer “Risk + Prevention” (see green tabs at top of this page).

Phase I data on a “novel herbal therapy”

There is some media buzz around publication of the results of a Phase I trial of Zyflamend, a commercially available herbal concoction that is supposed to be able to “affect the inflammation responses and may serve an important function in promoting normal cell growth in the colon, pancreas, breast tissue, and other organ systems.” However, [...]

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