Prostate cancer news reports: Tuesday, June 30, 2009

In todayas news reports we deal with items about: Celecoxib therapy prior to radical prostatectomy for cT1-2 disease Sentinel lymph node dissection (again) Surgical decompression and spinal reconstruction in man with spinal metastasis

More media coverage on prostate cancer screening

An article to be published in the July/August issue of CA: A Cancer Journal for Clinicians, but not yet available on line, as well as the accompanying editorial, is causing a flurry of new, and somewhat misleading, media information about the association between individual testing for risk of prostate cancer and the potential of mass [...]

Risks from selenium — in men WITH prostate cancer

A recent study from researchers at the University of California, San Francisco and the Dana-Farber Cancer Center is now suggesting that elevated selenium levels in the blood may worsen prostate cancer outcomes in some men who already have the disease.

Quality of life and long-term cancer survival: the RENEW trial

The “Reach Out to Enhance Wellness” (RENEW) trial was initiated as a randomized multi-center, multi-national trial to actually prove something which many would consider to be “obvious”: the idea that lifestyle modification will help cancer survivors to avoid the risks that they are at for second malignancies, other comorbidities, and accelerated functional decline.

Prostate cancer news reports: Saturday, June 27, 2009

Today’s news reports deal with such items as: Genomic testing for prostate cancer and the value of specific SNPs What do pre-treatment MRI/MRSI tests and molecular profiling add to prognostic significance? Quality of life following salvage brachytherapy

A topical update on free/total PSA

Two recent publications have dealt with issues related to the appropriate application of the free/total PSA ratio test in patients at potential risk for prostate cancer.

ED in men screened for prostate cancer risk?

Risk for erectile dysfunction (ED) after prostate cancer treatment is commonly assumed to be a reason why many men avoid being tested for their risk for prostate cancer. Whether that is really true or not is actually not well understood.

Vitamin D and prostate cancer: a strong set of recommendations

A new review makes some strong recommendations regarding the impact of serum levels of 25-hydroxyvitamin D — also known as 25(OH)D — and its metabolites and the effects on risk for several forms of cancer (including aggressive forms of prostate cancer).

Sentinel lymph node dissection in prostate cancer

A technique known as sentinel lymph node dissection (SLND) has replaced extended lymphadenectomy for nodal staging in several types of solid tumor cancers.

Prostate cancer news reports: Friday, June 26, 2009

Today’s prostate cancer news report summary includes items dealing with: The epigenetics of prostate cancer and their potential importance Selenium + vitamin E + lycopene (in mice) Gleason 7: 4 + 3 versus 3 + 4 — it’s important Proton beam radiotherapy — a topical review EBRT + low dose, permanent seed brachytherapy

All pumped up about PARPs

A report in this week’s issue of the New England Journal of Medicine (which is never shy about promoting itself) provides more early, and interesting, evidence of the future potential of so-called PARP inhibitors in cancer therapy.

Proton beam vs. intensity-modulated RT: out on the battle lines

The relative merits of proton beam radiotherapy (PBRT) and the more commonly available intensity-modulated radiotherapy (IMRT) as forms of external beam radiation for prostate cancer are much debated … with minimal supportive evidence on either side of the debate because no comparative trial has ever been carried out.

Prostate cancer news reports: Wednesday, June 24, 2009

Today’s news reports include discussion of items on: Prostate cancer risk awareness Improving cryotherapy technique with 3D ultrasound Interposition (“sural”) nerve grafting Post-brachytherapy “PSA bounce” The potential of targeted, peptide-linked, α-emitting radioisotopes

OGX-011 to enter Phase III trials for CRPC

OncoGenex Pharmaceuticals has just announced today that the company is “ready to proceed with two Phase 3 trial designs” for its investigational drug OGX-011, “one in first-line and one in second-line treatment of advanced prostate cancer.”

Second pathologic opinions: do they change patient management?

We have long known that prostate cancer specimens (and specimens for other urologic malignancies) can be very difficult for pathologists to evaluate with accuracy, and that second pathological opinions can be helpful in ensuring an appropriate diagnosis prior to treatment and/or an appropriate prognosis after radical surgery.

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