http://prostatecancerinfolink.net/2009/06/08/bisphosphonate-therapy-and-osteonecrosis-of-the-jaw/ Tue, 14 Feb 2012 14:47:30 +0000 hourly 1 http://wordpress.com/ http://prostatecancerinfolink.net/2009/06/08/bisphosphonate-therapy-and-osteonecrosis-of-the-jaw/#comment-5103 Sat, 13 Jun 2009 02:25:47 +0000 http://prostatecancerinfolink.net/?p=5956#comment-5103 It’s becoming clear what the ONJ risks are, but what are really the BENEFITS of IV bisphosphonates for metastatic prostate cancer and others? My past study suggests that the risks and benefits are coming close to overlapping.

]]> http://prostatecancerinfolink.net/2009/06/08/bisphosphonate-therapy-and-osteonecrosis-of-the-jaw/#comment-5088 Tue, 09 Jun 2009 13:46:29 +0000 http://prostatecancerinfolink.net/?p=5956#comment-5088 The “new ” recommendations for a thorough dental examination and completion of necessary dental work prior to initiating bisphosphonate therapy are actually not new to what physicians specializing in the treatment of prostate cancer have been directing. However, another consideration that was advanced by Medical Oncologist Stephen Strum some time back is important: “I believe it is possible that I have not seen this problem because I advise my patients to use a comprehensive bone supplement such as Bone Up by Jarrow or Bone Assure or Bone Restore by Life Extension. In the past, issues of bone brittleness relating to therapies using fluoride or bisphosphonates have come up. In both situations, I have found that such a problem relates to NOT supplying the patient with the needed raw materials to make healthy bone. And, one other point. This process is called avascular necrosis & drugs which inhibit angiogenesis might be working with bisphosphonates to create SYNERGISTIC TOXICITY. It is known that part of the mechanism of action of bisphosphonates is that of anti-angiogenesis. Therefore, think carefully when adding additional anti-angiogenesis agents to bisphosphonate therapy. This includes drugs like thalidomide, tetracyclines, and COX II inhibitors like Celebrex. These may be found to be risk factors”

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