Using PSA progression to predict survival in clinical trials

Because it takes so long for men with even advanced prostate cancer to progress through to death from any cause, there has been extensive effort over the years to define “surrogate” endpoints for prostate cancer-specific and overall survival in prostate cancer clinical trials.

Serum calcium levels and prostate cancer risk

In yet another example of the “maybe or maybe not” world of what helps to trigger increased risk for prostate cancer, we can now place serum calcium levels. Some recent studies (e.g., Skinner and Schwartz) have suggested an association between high levels of serum calcium and a high risk of prostate cancer death. Now an [...]

Prostate cancer news reports: Wednesday, June 3, 2009

Today’s news reports address: Additional new markers associated with prostate cancer risk Relationships between age, total PSA level, and percentage free/total PSA in a cohort of screened patients Are African-Americans at higher risk for positive surgical margins? High-dose brachytherapy after abdominoperineal resection and pelvic external beam radiation

Prostate cancer prevention and screening: an ASCO update

Your editor was unable to attend the session on prostate cancer prevention and screening at the recent annual meeting of the American Society for Clinical Oncology (ASCO) because he is still working on how to be in two places at once.

Prostate cancer news reports: Tuesday, June 2, 2009

There continue to be a multitude of news reports from the ASCO meeting today — some of which seem to be based more on media releases than on what was actually presented by the investigators who carried out the research (caveat emptor). The news items mentioned below deal with items unrelated to ASCO: The prognostic [...]

A Phase III clinical trial of Sprycel + Taxotere in CRPC

Bristol-Myers Squibb has announced the launch of the READY Phase III trial designed to compare dasatinib (Sprycel) + docetaxel (Taxotere) + prednisone as first-line chemotherapy compared to placebo + docetaxel + prednisone in men with metastatic castration-resistant prostate cancer (CRPC).

Prostate cancer in America today: what should be top of mind?

For the patient who has prostate cancer, and for his family, things are very personal. These patients have important clinical needs that we must try to meet. But when we talk about prostate cancer more generally — to our friends, to our family members, to our state and federal legislators and public health officials, it [...]

How many types of prostate cancer are there?

At a meeting of some leading members of the prostate cancer advocacy community yesterday morning, during the ASCO meeting in Orlando, Dr. William Simons of the Prostate Cancer Foundation distributed a diagram suggesting that there may be as many as 15-18 different sub-types of prostate cancer.

ASCO commentary and update no. 4

There were about 50 prostate cancer-specific posters presented in the general poster session on Sunday, and we will give a quick overview of some of the more interesting ones.

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