The earliest known case of advanced, metastatic prostate cancer

Some people are apparently under the impression that prostate cancer is a “modern” cancer and that there is no evidence of this disease in earlier times. We can assure you that this is not the case.

Additional data on short-term outcomes of PBRT

A new report from researchers at the University of Florida Proton Therapy Institute offers us some additional information on the short-term outcomes of first-line treatment with image-guided proton beam radiation therapy (PBRT) for localized prostate cancer.

NCI takes first step to re-vamp clinical trials process in US

On December 23, the National Cancer Institute (NCI) issued a media release announcing a first step toward major changes in how big, cooperative clinical trials get managed and funded in the USA.

Second study confirms data on PSADT and survival post-surgery

In 2009, at a presentation at the American Society for Clinical Oncology, Antonorakis et al. initially presented data, from the Johns Hopkins database, demonstrating the prognostic significance of PSA doubling time (PSADT) to long-term survival of men with progressive prostate cancer who were otherwise untreated after surgery.

Does ADT raise your risk for cataracts?

The proposed list of complications as a consequence of androgen deprivation therapy (ADT) for advanced prostate cancer has just been increased.

Why men choose specific first-line types of management for localized prostate cancer

The need for patients diagnosed with early stage prostate cancer to be highly involved in the decision as to which form of management they wish to be given is well understood. However, there has been a relative dearth of data on why patients actually make their individual decisions.

Side effects of surgery among patients diagnosed in the Göteborg screening trial

In July this year, we commented on the 14-year mortality data published by Hugosson et al. from the randomized, population-based, prostate cancer screening trial initiated in Göteborg, Sweden, in 1995.

Castrate serum T levels and prostate cancer-specific mortality

A few weeks ago, a Letter to the Editor in the New England Journal of Medicine focused on the significance of castrate levels of serum testosterone (serum T) in men being treated with LHRH agonists for advanced forms of prostate cancer.

5-year outcomes data from a French series of HIFU patients

A new report from a French research team has provided detailed 5-year data on the oncological outcomes of a series of low- and intermediate-risk prostate cancer patients treated with high-intensity ultrasound (HIFU) using second-generation Ablatherem™ equipment.

A patient-centric approach to the discussion about testing for prostate cancer risk

There is no consensus about the appropriateness of widespread testing for risk of prostate cancer. While many guidelines recommend that primary care physicians have a structured conversation with their male patients about the appropriateness of such testing, we had not (before today) come across any sound guidance for the primary care community about how to have that discussion.

Inflammation, biomarkers, and risk for prostate cancer

Whether there is any real association (let alone a cause and effect correlation) between clinically evident or subclinical inflammatory disorders and risk for prostate cancer is still not known — although long suspected.

Interpretation, speculation, and the politics of prostate cancer

On Tuesday this week, an article appeared on the widely-read Politico web site entitled “The politics of prostate cancer.” It was based on the recent surgical treatment of U.S. Senator Ron Wyden. And it included some rather odd statements.

Can we reduce adverse effects of ADT through cyclical estrogen therapy?

The adverse effects of androgen deprivation therapy (ADT) resulting from the use of surgical castration (orchiectomy) or medical castration (luteinizing hormone-releasing hormone [LHRH] agonists) are extensive, including sexual dysfunction, hot flashes, osteoporosis, and many others.

Adverse effects of first-line treatments for localized prostate cancer

Prospective data from a significant Spanish study provide us with additional insights into the short- and longer-term adverse effects of common types of invasive therapy for localized prostate cancer.

When is localized prostate cancer clinically insignificant?

Among prostate cancer specialists, there has been a broad acceptance — for some time — of the idea that a localized prostate cancer “index” tumor with a Gleason score of 6 or less and a volume of ≤ 0.5 cm3 could be considered to be clinically insignificant and therefore did not (necessarily) need to be treated.

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