Chromosome catastrophe theory: an introduction to “chromothripsis”

According to a new paper in the journal Cell, researchers at the Sanger Institute at Cambridge, in England, believe they have discovered a completely new mechanism for the initial development of about 2 or 3 percent of all cancers.

More from the European comparative effectiveness research front

Apparently the German health system is to initiate a large trial to investigate the comparative effectiveness of four different treatments for men initially diagnosed with low-risk prostate cancer, starting this year.

5-year data on treatment of low-risk patients with SBRT

A new article in Radiation Oncology provides initial 5-year outcomes of patients treated with stereotactic body radiation therapy (SBRT), also known as CyberKnife therapy.

First androgen receptor mRNA antagonist enters clinical trials for CRPC

Over the past 5 or so years we have seen a remarkable growth in the diversity of pharmaceuticals being developed for the treatment of more advanced forms of prostate cancer, and there is no sign of a slow-down yet.

Age and co-morbidity as risk factors for over-treatment of low-risk prostate cancer

In recent years, it has become increasingly well understood that patients diagnosed with low-risk prostate cancer are potentially susceptible to over-treatment. This is particularly the case among men who have significant degrees of co-morbidity and men greater than 75 years of age who have a life expectancy of < 15 years.

What you believe may not be good for you

A study by researchers at the University of Miami and Yale School of Medicine suggests there may be an association between patients’ beliefs about the potential curability of prostate cancer and their overall, long-term survival.

IMPT: a new acronym we’re all going to need to learn

Back in the mid-1990s there was 3D-CRT (three-dimensional conformal beam radiation therapy), the first type of external beam radiation designed to “shape” the way that beams of radiation were used to treat the prostate in conformance with the actual shape of the individual prostate.

Penile length after RALP and rehab: a small, single-center case series

Over the years a number of studies have documented a reduction in penile size after open radical retropubic prostatectomy. A newly published study reports on the impact of robot-assisted laparoscopic radical prostatectomy (RALP) and penile rehabilitation on penile size.

KW-2170 not sufficiently active for use in men with CRPC

KW-2170 is a drug that had been undergoing early clinical trials in Australia for the treatment of men with castration-resistant prostate cancer (CRPC).

Comparative evaluation of open vs. robot-assisted surgery for localized prostate cancer

A new paper in the Scandinavian Journal of Urology and Nephrology has provided detailed information about the design and conduct of an ongoing, prospective, non-randomized trial comparing open radical retropubic prostatectomy (RRP) to robot-assisted laparoscopic radical prostatectomy (RALP) in treatment of localized prostate cancer.

87 percent of Americans willing to be tested for prostate cancer (maybe)

According to a report on the Scientific American web site, 87 percent of respondents to a survey conducted by researchers at Tufts Medical Center would be willing to have a hypothetical “predictive” test for prostate cancer.

A new and balanced guidebook to all the possible options

The majority of books on prostate cancer — for the newly diagnosed and for the patient with progressive disease — come with a particular point of view about one form of treatment or another … even when they do carefully mention all of the options.

Algeta completes enrollment in Phase III trial of radium-223 chloride

According to a media release issued by Algeta this week, the company has completed patient enrollment into a large, Phase III trial evaluating radium-223 chloride in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) in which metastases are clearly evident in bone.

Delayed onset of castration resistance with serum T-based LHRH agonist regimens

A new paper just published online in Urology suggests that intermittent and testosterone (T)-based LHRH regimens are less likely to be associated with early onset of castration resistance than traditional, continuous, calender-based regimens.

Social networking, science, and prostate cancer support

As many readers will be aware, we have a social network as an adjunct to The “New” Prostate Cancer InfoLink. We were therefore very interested in what appears to be the first published scientific paper on the application of social networking specifically to prostate cancer education and support.

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