Erectile function, motivation, sex, and satisfaction post-surgery

A recent article offers data from an initial investigation of the impact of sexual motivation on the sexual health and satisfaction of men treated by radical prostatectomy (RP) for localized prostate cancer.

Wishful thinking about abiraterone acetate in CRPC

An article from Thursday’s “The Pink Sheet”, posted on the OncologySTAT web site today, is already asking questions about the potential future use of abiraterone acetate in patients with non-metastatic, castration-resistant prostate cancer (CRPC).

Post-surgical salvage radiation therapy and all-cause patient mortality

An article just published on-line in Cancer has demonstrated that, in a cohort of men with a median follow-up of  > 10 years, salvage radiation therapy (after first-line radical prostatectomy) reduces all-cause mortality in men with short (< 6 months) and longer (≥ 6 months) PSA doubling times at the time of initial biochemical disease progression.

The long-term results of RTOG 98-05 — an innovative brachytherapy trial

The recently published long-term results of RTOG 98-05 illustrate at least one way in which we can start to get better insight into the effectiveness and safety of new forms of treatment for localized prostate cancer as compared to older forms of treatment — without having to conduct complex and socially difficult randomized clinical trials.

Genetics, genomics, and improvements in the management of prostate cancer

Over the past few years we have seen a great deal of discussion of this or that new gene or single nucleotide polymorphism (SNP) or other set of genomic data and the potential of such information to improve the diagnosis or the prognosis of prostate cancer.

FDA approval of abiraterone: some interesting notes

We have already noted the FDA’s approval of abiraterone acetate. However, there are some interesting details that are worthy of note.

STOP PRESS … FDA approves abiraterone acetate

The FDA has today approved abiraterone acetate (Zytiga™) for use in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) who have received prior chemotherapy containing docetaxel. A full media release is already available on the Centocor Ortho Biotech web site. There is another media release on the FDA web [...]

Cancer research and America’s minority populations

A special report just issued by the President’s Cancer Panel says that the United States urgently needs to expand research and improve understanding of cancer among minority populations.

Longer screening intervals for men with PSA levels < 2 ng/ml?

The April 15 issue of The ASCO Post (a widely circulated magazine for oncologists and others) carries a lead article entitled “Longer screening intervals make sense in men with initial PSA levels < 2 ng/ml.”

A matched, case-control study of EBRT + PBRT vs brachytherapy

It would be all too easy to get the idea — from the title and abstract of a recently published study — that proton beam radiation therapy (PBRT) was more effective than permanent seed brachytherapy in the treatment of men with low- and some intermediate-risk prostate cancers. This would be a very inappropriate conclusion.

EBRT as salvage therapy for refractory or progressive prostate cancer post-HIFU

An early release paper in the Canadian Urological Association Journal offers information on a series of patients treated with external beam radiation therapy (EBRT) as salvage therapy after biochemical progression following high-intensity focused ultrasound (HIFU) as their first-line treatment.

Inguinal hernia after open radical retropubic prostatectomy

A review article published on-line in Nature Reviews Urology has suggested that over the past decade some 15 to 20 percent of men undergoing open radical retropublic prostatectomy (RRP) as first-line treatment for prostate cancer have an inguinal hernia as a complication of their treatment.

But is it safe and effective in people as opposed to Petri dishes?

A newly published report in the International Journal of Cancer has concluded that  the non-prescription supplement ProstaCaid™ “is a promising natural complex with the potency to inhibit invasive human prostate cancer.”

Do “macho” men risk dying young?

A study in the Journal of Health and Social Behavior reports data suggesting that stereotypically “macho” attitudes to masculinity are associated with a reduced likelihood of participation in preventive care.

Radiation therapy for men with locally advanced prostate cancer: a meta-analysis

Data from a meta-analysis of four, large, randomized, clinical trials of radiation therapy for locally advanced forms of prostate cancer suggests that radiation treatment lowers risk for metastasis and prostate cancer-specific mortality (PCSM), but that patient age at the time of treatment is a key factor too.

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