Perception, expectation, risk, screening, and cancer reality

Over the past 20 years, the role of “screening” as a mechanism for early diagnosis of several types of cancer (and other diseases) has become a high-profile and emotional issue in which the value of accurate data has often been swamped by media hype and the claims of specific interest groups. This is true for [...]

Additional 5-year follow-up data on SBRT for localized prostate cancer

In February this year we reported initial 4- and 5-year follow-up data from two US-based research teams on the use of stereotactic body radiation therapy (SBRT or CyberKnife radiation) as a treatment for prostate cancer. A new study from a Korean research group appears to confirm the earlier findings.

Diagnosis and management of localized prostate cancer: the Cleveland Clinic approach

A recent article in the Cleveland Clinic Journal of Medicine provides a summary of the way three leading specialists at this institution approach the diagnosis and management of localized prostate cancer today.

Age, exercise, and ADT: effects on health and fitness in prostate cancer patients

While there is general consensus that exercise helps to minimize the impact of androgen deprivation therapy (ADT) on body composition, fitness, and other factors, there is limted evidence from clinical trials about the specific types of exercise that may be of greatest value.

The making of “a good doctor” today

What goes into the making of “a good doctor” is an underlying issue in many of the comments and observations that get posted on this and other, primarily patient-focused web sites. An article in this week’s issue of The Lancet deals with this issue head on, and in a very readable manner.

How Finnish doctors think about prostate cancer screening

Finland was a major participant in the European Randomized Study of Screening for Prostate Cancer (ERSPC). It is therefore useful to get insight into how the Finnish medical profession thought about screening for prostate cancer over the time period when this trial was being carried out

Results of abiraterone acetate Phase III trial in today’s NEJM

According to a media release issued by Centocor Ortho Biotech late yesterday, the final results of the Phase III clinical trial of abiraterone acetate + prednisone vs. prednisone alone in men with metastatic, castration-resistant prostate cancer (mCRPC) have been published in today’s issue of the New England Journal of Medicine.

“PSA and the family physician”

The full text of a recent article having the above title offers a good (if perhaps not perfect), reasonably current overview of issues related to PSA testing for prostate cancer and appeared recently in a supplement to the Canadian Journal of Urology.

Avanafil shows benefit against ED in prostate cancer patients post-surgery

According to media information released earlier today by Vivus, Inc., the company’s selective, investigational phosphodiesterase type 5 (PDE5) inhibitor known as avanafil has shown positive results in a randomized, double-blind, multi-center, placebo-controlled Phase III clinical trial for the treatment of erectile dysfunction (ED) in patients after a radical prostatectomy.

How young men have thought about treatment options for Gleason 6 prostate cancer

A new study based on data from nearly 500 patients gives us some insight into how a selected group of men less than 50 years of age were thinking about treatment for prostate cancer between 2001 and 2005. Whether one would get the same results for a similar group of patient diagnosed today is a good [...]

New data suggest that acetaminophen may prevent prostate cancer

Over the years, a variety of studies have demonstrated a possible impact of aspirin and other non-steroidal anti-inflammatory agents or NSAIDs (e.g., ibuprofen, COX-2 inhibitors) on risk for prostate cancer. (See, for example, this report from late in 2010.)

Prevalence of men with differing stages of prostate cancer in the USA

One of the posters to be presented at the upcoming annual meeting of the American Society of Clinical Oncology offers an interesting model permitting replicative estimation of the numbers of patients living with different clinical stages of prostate cancer.

Testosterone replacement therapy in men with low serum T and untreated prostate cancer

An article in the May issue of BJU International has proposed establishment of an international data registry as being “the quickest way” to establish basic data on the risks related to testosterone replacement therapy in men with untreated prostate cancer.

The relative aggressiveness of prostate cancer in black and white patients

A newly published article, available on-line in the journal Prostate Cancer and Prostatic Diseases, shows that tissues from prostate biopsies from black men express higher levels of biomarkers for aggressive disease than do tissues from prostate biopsies taken from white men.

New Phase III trial of “gene suicide therapy” in localized prostate cancer

A biopharmaceutical company called Advantagene, Inc. announced last Thursday that it has reached agreement with the U.S. Food and Drug Administration regarding the conduct of a Phase III clinical trial of a vaccine-like treatment called ProstAtak™ — in combination with standard therapy — in the treatment of patients with newly diagnosed prostate cancer.

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