Expert opinions on active surveillance and surgery for localized prostate cancer

At least some readers of this news-blog may be interested in two items posted earlier today on the Medscape Oncology web site.

FDA approves Phase I/IIa trial of APC-100

According to information on the MSN Money web site, Adamis Pharmaceuticals has received approval from the U.S. Food & Drug Administration of its Investigational New Drug (IND) application and been give approval to initiate a Phase I/IIa clinical trial of APC-100 for the treatment of men with castration-resistant prostate cancer.

Two more nails in the coffin of XMRV

As long ago as December 2008 we first referred to the possibility that the xenotropic murine leukemia virus-related virus (XMRV) might have some association to risk for prostate cancer.

Age and risk for incontinence after radical prostatectomy

A new analysis of data from a large, consecutive series of Swedish patients suggests a very strong correlation between age at time of radical prostatectomy and risk for significant, long-term urinary leakage.

“Take home” messages about localized prostate cancer from the AUA annual meeting

An article by Crawford and Arangua on page 3 of the June issue of AUA News provides a series of “take home messages” for attendees of the annual meeting of the American Urological Association in Washington, DC, last month.

How surgeons and patients think about post-surgical incontinence

We are coming to the conclusion that there is a deep divide between how some surgeons think about post-surgical incontinence following radical prostatectomy for their prostate cancer and how patients may think about such incontinence when defined by exactly the same set of clinical symptoms and quality of life issues.

FDA lifts “hold” on clinical development of GVAX

As previously reported a little over a year ago, BioSante Pharmaceuticals is trying to re-initiate the development of the GVAX vaccine product for the treatment of prostate cancer.

The latest update on XL184 (cabozantinib)

A new update was provided at the ASCO meeting today on progress from the Phase II clinical trial of XL184 (cabozantinib) in the treatment of men with metastatic, castration-resistant prostate cancer (mCRPC).

Alpharadin shows 2.8-month survival benefit in mCRPC

The investigational radioisotope radium-233 chloride (Alpharadin) has shown a small but clinically significant overall survival benefit in the treatment of men with symptomatic, metastatic, castration-resistant prostate cancer (mCRPC).

The management of “hot flashes” for men on ADT

Perhaps the most interesting new data from the annual meeting of the American Society of Clinical Oncology yesterday (Sunday) was a negative result from a four-arm, randomized clinical trial.

Survival and CTC data from the abiraterone acterate pivotal trial

As we have previously reported, the latest analysis of survival data from the pivotal Phase III trial of abiraterone acetate + predisone has shown a slight improvement in the survival benefit for patients treated with abiraterone (Zytiga™).

GI toxicity, radiation therapy, and androgen deprivation

For men undergoing the combination of external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT), for treatment of prostate cancer there is a significant risk for gastrointestinal (GI) toxicity over time.

Preliminary data on itraconazole in treatment of mCRPC

Preliminary data from a Phase II clinical trial have suggested that the antifungal drug itraconazole, when used at high dose levels, may have clinical benefit in the treatment of metastatic, castration-resistant prostate cancer (mCRPC).

“Bloodletting and the management of localized prostate cancer”

Many patients and advocates will benefit from reading (possibly with both horror and pleasure) the article with the above title by Professor Curtis Nickel in the current issue of the Canadian Urological Association Journal. So may many in the urology community.

Perineural invasion and risk for progression in localized and locally advanced disease

A new study by an Austrian research team has further helped to clarify the potential prognostic significance of perineural invasion as a risk factor in the progression of localized and locally advanced forms of prostate cancer.

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