Prostate cancer, BPH, risk association, and a 3 million man study

A commonly raised question is whether men with benign prostatic hyperplasia (BPH) are at greater risk for prostate cancer than men who have no sign of BPH. A new, nation-wide study of the male population of Denmark over the past 27 years offers us some insights.

Should the DRE really be “optional” today?

Until very recently, all available guidelines for the early assessment of risk for prostate cancer clearly recommended the use of a physical examination (a digital rectal exam or DRE) in addition to a prostate-specific antigen (PSA) test.

Climacturia as a side effect of radical prostatectomy

“Climacturia” is the involuntary release of urine at the time of orgasm during sexual activity. A new paper by a Swedish research team has expanded our understanding of the prevalence of this problem among men after surgery for localized prostate cancer.

Proton beam radiation therapy in prostate cancer

Three new articles in the June 15 issue of Oncology review the current data and the potential of proton beam radiation therapy (PBRT) as a first-line treatment for localized prostate cancer. The full texts of all three articles are available on line.

Race and outcomes after prostate brachytherapy

A new retrospective analysis of data from > 2,300 patients suggests that African-American men are a greater risk for biochemical disease recurrence after brachytherapy alone than Hispanics or Caucasian men, but

Medicaid patients do get better health care than America’s uninsured

The “New” Prostate Cancer InfoLink is delighted to see the early results of a major study conducted by the National Bureau of Economic Research which has effectively proven that patients on Medicaid find regular doctors, see those doctors more often, feel better, are less depressed, and are better able to maintain financial stability than those [...]

Regeneron to continue VENICE trial of aflibercept

According to a media release from Regeneron Pharmaceuticals, the company plans to continue the randomized, multi-center, Phase III VENICE clinical trial, designed to evaluate the efficacy and safety of aflibercept (ZALTRAP™) in combination with docetaxel in the first-line treatment of patients with metastatic, hormone-refractory prostate cancer.

Current status of proposed funding for the DoD PCRP in FY 2012

An amendment  to the Defense Appropriations Act offered by Congressman Cliff Stearns (R, FL) on the floor of the House of Representatives yesterday has added back $16 million to the Department of Defense’s Prostate Cancer Research Program (PCRP). The amendment was passed by a voice vote and supported by members of both political parties.

PSA testing, prostate cancer mortality, and an update from the Tyrol

Back in 2006 a report from a research team in the Tyrol, Austria, suggested that the availability of free PSA testing for prostate cancer risk had lowered the risk of prostate cancer mortality in the Tyrol as compared to all other areas of Austria. This original study is discussed elsewhere on this web site.

Low-risk prostate cancer, active surveillance, and perineural invasion

A previously unanswered question is whether a finding of perineural invasion in the biopsy cores of men who otherwise meet all relevant criteria for management by active surveillance does or does not actually increase risk for progressive forms of prostate cancer.

Quality of life, quality of death, and “end of life care”

Here in the USA, while our legally elected representatives in Washington, DC, pontificate about “death panels” and try to score political points over which of our two major political parties is more likely to “ration Grandpa to death,” most of us do, in fact, appreciate that we are going to die (at some point) and [...]

Risk factors for vertebral fractures among men on ADT

White race and low bone mineral density (osteoporosis) appear to be the only two of a dozen different potential risk factors that significantly increase the likelihood of vertebral (spinal and hip) fractures among men being treated with androgen deprivation therapy (ADT) for prostate cancer.

Great Nonprofits “top-rates” Prostate Cancer International (thanks to you)

We are pleased to announce that Prostate Cancer International (the parent non-profit organization that provides the services of this web site) has been rated as one of 122 “Top-Rated Health Nonprofit”  organizations based in the USA by Great NonProfits as a consequence of their recent “Health Campaign 2011.”

(At least in Ontario) it’s not about where you have your surgery

Over the years, data have clearly shown that where a patient has surgical treatment for localized prostate cancer has little impact on short- and long-term outcomes (although who carries out the surgery very definitely does).

Recovery of serum T levels after short-term LHRH agonist therapy

An article in the June issue of the Canadian Urological Association Journal offers preliminary evidence from a randomized clinical trial that men treated for 6 months with a short-acting LHRH agonist may recover normal serum testosterone (T) levels faster than those treated for the same time with a long-acting LHRH agonist.

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