The personalization of prostate cancer management: a way to go yet!

A new study just published in the Journal of General Internal Medicine makes a strong case for the importance of individualized application of specific treatments to older men diagnosed with prostate cancer — something which you would think ought to be evident to the majority of clinicians, but apparently wasn’t

Eggs, prostate cancer, and the Daily Mail

Our friends at The Daily Mail in the UK have been spreading a story that men who eat 2.5 eggs or more a week have an 81 per cent increase in their risk for lethal prostate cancer compared to men who do not.

UK’s National Health Service will not pay for cabazitaxel in mCRPC (at the proposed price)

According to a report in today’s Daily Telegraph, the UK’s National Institute for Health and Clinical Excellence (NICE) has determined that “cabazitaxel would not be a cost effective use of limited NHS resources” for the treatment of men with metastatic, castration-resistant prostate cancer (mCRPC).

Long-term watchful waiting and quality of life outcomes (compared to immediate treatment)

A new study in the Journal of Urology reports data on a cohort of 125 patients enrolled in the Physicians’ Health Study (PHS) who elected to be managed with watchful waiting for a minimum of 1 year after their initial diagnosis and who were followed for an average (mean) of 7.3 years.

Saw palmetto extract does not shrink prostate size (redux)

Saw palmetto extract (made from the berries of the saw palmetto plant, Serenoa repens) is widely used by many men to prevent or treat benign enlargement of the prostate (benign prostatic hyperplasia). While it is not known to have any effect on prostate cancer, the use of saw palmetto has long been a topic of [...]

How much hypofractionated IMRT is too much for localized prostate cancer?

A report to be presented at the upcoming meeting of the American Society for Radiation Oncology (ASTRO) offers 5-year outcome data from a trial comparing conventional intensity-modulated radiation therapy (IMRT) to the more recently developed hypofractionated IMRT for men with localized prostate cancer.

New data on the genetics of aggressive prostate cancer, but …

A new paper in the Proceedings of the National Academy of Sciences suggests the existence of a subset of “hypermutated” cell lines in some forms of aggressive prostate cancer.

Abiraterone acetate treatment affects fatigue in men with mCRPC

According to a retrospective analysis of data from a randomized, double-blind, Phase III clinical trial, abiraterone acetate (Zytiga™) can significantly lower levels of fatigue in men with metastatic, castration-resistant prostate cancer (as well extending survival).

28-year risk for prostate cancer in Copenhagen based on baseline PSA data

Between 1981 and 1983 researchers collected and stored blood samples from 4,500 men in Copenhagen, Denmark, as part of the Copenhagen City Heart Study. These blood samples had been carefully stored — and otherwise unused — for nearly 30 years. In 2010, a new research team decided to measure the PSA levels in these blood [...]

Ibandronate for relief of pain in men with metastatic prostate cancer

According to another study presented at the European Multidisciplinary Cancer Congress (EMCC) in Stockholm this weekend, the bone-strengthening bisphosphonate ibandronate (Boniva®) seems to work just as well as radiotherapy for the management of pain associated with prostate cancer that has metastasized to the bones.

Full data report from the ALSYMPCA trial of radium-223 presented

According to a company media release, the full results of the ALSYMPCA  trial were presented Saturday at the European Multidisciplinary Cancer Congress (EMCC). This is the trial of the injectable radioactive agent radium-223 chloride (Alpharadin®) in men with symptomatic, metastatic, castration-resistant prostate cancer (mCRPC).

The economics of prostate cancer (in the “western” world)

A new “mini-review” in BJU International provides a summary overiew of the “economic burden” of prostate cancer, largely based on data from the “western” nations (inclusive of Europe, North America, and Australasia).

U.S. FDA approves NADiA ProsVue prognostic test for prostate cancer

According to a media release issued on Thursday by IRIS International, the U.S. Food & Drug Administration (FDA) has approved the company’s NADiA® ProsVue™ test as a prognostic marker that can “aid in identifying” men at reduced risk for recurrence of prostate cancer in the first 8 years after a prostatectomy.

New data on risks of prostate biopsy and prostate cancer diagnosis, follow-up

According to a new study among Medicare beneficiaries in the USA, researchers have found that 6.9 percent of men having a prostate biopsy are hospitalized within 30 days of the biopsy compared to 2.7 percent of a control group of men who did not have a prostate biopsy.

Predicting sexual function after first-line treatment for prostate cancer

A newly published report in the Journal of the American Medical Association provides data (from two large cohorts of patients) on the quality of sexual function among men undergoing first-line treatment for localized prostate cancer.

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