What FDA drug approval does and does not mean

If you are among the people in America who agree with one or other of the following two statements, you need an immediate crash course in what approval of a new drug by the U.S. Food & Drug Administration (FDA) does actually mean:

The man who wishes he’d never had the PSA test he demanded

There is an interesting article on Kaiser Health News today discussing the risks associated with “over-testing” of elderly and sometimes very infirm people who are at relatively low risk for specific chronic diseases, including prostate cancer.

De. Gerry Chodak on “LIVE! with Dr. Sandy”

Dr. Gerry Chodak is the author of Winning the Battle Against Prostate Cancer, the creator of the ProstateVideos.com web site, and the founder of the Chicago-based patient support group that became the basis for Us TOO International.

An introduction to the concept of intermittent ADT

Initially, androgen deprivation therapy (ADT) was conceived of and developed as long-term, palliative therapy for men with evident and commonly painful forms of metastatic prostate cancer. The primary goal was the alleviation of pain associated with metastasis, and had little or nothing to do with the patient’s long-term survival.

Oncothyreon enrolls first patient in Phase II trial of PX-866 for CRPC

Oncothyreon, Inc. has announced initiation of a Phase II clinical trial of the company’s investigational agent PX-866 in the treatment of men with chemotherapy-naïve, recurrent or metastatic, castration-resistant prostate cancer (CRPC).

Bisphosphonates in management of osteoporosis: an FDA update

Last Friday a U.S. Food & Drug Administration (FDA) advisory committee recommended (based on a 17 to 6 vote) that the labeling of bisphosphonates needed to be updated to make it clear how long patients should take these drugs to gain the greatest benefit and suffer the least risk.

What does your doctor mean by “localized” prostate cancer?

Every day across America and around the world, newly diagnosed patients are told they have “localized” prostate cancer … with the associated implication that this is a relatively “good thing” compared to a diagnosis of “advanced” prostate cancer.  But what does “localized” prostate cancer really mean in individual cases?

New decision aid for men with clinically localized prostate cancer

The Agency for Healthcare Research and Quality (AHRQ) has just released a new, free decision aid to assist men diagnosed with clinically localized prostate cancer in the assessment of their management options.

Canadian company claims new test is 600% more accurate than free PSA test

According to a media release issued by the Canadian company BioCurex earlier today, its new RECAF™ test “outperformed the established free-PSA test by approximately 600% in its ability to prevent unnecessary prostate biopsies.”

Another update on cabozantinib (XL184)

Exelexis has issued a media release stating that “the pre-specified number of progression-free survival (PFS) events required for un-blinding of the data for the ongoing Phase III pivotal trial of cabozantinib in patients with medullary thyroid cancer (MTC), known as the EXAM trial, has been reached.”

European Commission approves abiraterone acetate for mCRPC

Abiraterone acetate (Zytiga®) has been approved for clinical use in European Union nations, according to a media release from Johnson & Johnson issued earlier today. This final approval by the European Commission follows an earlier recommendation for approval issued by the European Medicines Agency (EMEA) at the end of July.

Clinical depression among prostate cancer patients: a 10-year analysis

The association of depression with a diagnosis of and subsequent treatment for prostate cancer is well appreciated, but the prevalence of that depression and the burden it places on men with prostate cancer over time has been less well documented.

Educating the family doctor about prostate cancer management

The August 15 issue of American Family Physician — supposedly one of the most widely read medical journals in America — carried an article by Mohan and Schellhammer entitled “Treatment options for localized prostate cancer.” Unfortunately the full text of this article is not available on line for the average reader.

What DID the doctor actually tell you about your prostate cancer?

It is well understood that there can be big differences between what we are told and what we later say and think that we heard. It is also the case that what we are told may commonly reflect the beliefs of the person doing the telling (as opposed to actual, factual information).

Let’s hear it for the broccoli and the brussels sprouts!

Over the years there have been many reports associating intake of cruciferous vegetables, tomato sauce, and legumes with a reduction in risk for advanced prostate cancer. However, definitive clinical data are still few and far between.

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