Poor science underlies the USPSTF recommendation about PSA-based screening

Whatever we may think individually about the recent decision by the U.S. Preventive Services Task Force to recommend against the use of PSA testing as a means of “screening” for risk of prostate cancer, we would be wise to understand that at the heart of this decision is poor science.

USPSTF “forced” to release PSA recommendations earlier than expected

The U.S. Preventive Services Task Force (USPSTF) — after previously stating that it would be releasing its new recommendations about PSA testing for risk of prostate cancer on Tuesday next week — has been pressured (by a variety of organizations, and by the media) to release its draft recommendation today.

Dr. Howard Scher on circulating tumor cells

A new article by Dr. Howard Scher of Memorial Sloan-Kettering Cancer Center on the OncologySTAT web site discusses recent developments in the application of levels of circulating tumor cells (CTCs) in clinical practice and in the assessment of outcomes in clinical trials.

Expert commentary on new drugs for mCRPC

A videotaped expert commentary by Dr. Johann de Bono on the Medscape Oncology web site (with transcript) discusses four therapies (three now approved in the USA) that have recently demonstrated a survival benefit in the treatment of metastatic, castration-resistant prostate cancer.

USPSTF advises against all PSA screening in healthy men

According to an article in today’s New York Times, the United States Preventive Services Task Force (USPSTF) has chosen to advise against routine use of the PSA test to screen healthy men for prostate cancer because “the test does not save lives and often leads to more tests and treatments that needlessly cause pain, impotence [...]

Watchful waiting vs. external beam radiation: 15-year data from a randomized trial

According to a report presented today at the annual meeting of the American Society for Radiation Oncology (ASTRO) in Miami Beach, Florida, men with localized prostate cancer who were treated 15 years ago with external beam radiation therapy had no significant survival benefit compared to men followed with watchful waiting.

To screen or not to screen … That is the question …

An article in the New York Times magazine, just published on the New York Times web site, takes on the debate we have all been involved in from different points of view for most of the past 20 years. People have passionate beliefs on this subject. We will just refer you to the article.

Sex after RP — it’s out there on the radio

Many readers of The “New” Prostate Cancer InfoLink may be interested in listening to or reading the transcript of a program on Science Friday on National Public Radio that aired last Monday.

Excess deaths among some older men with prostate cancer

A population-based analysis of mortality data for men diagnosed with prostate cancer from three European nations suggests that “a small but important group of older patients” initially present with late stage prostate cancer and die rapidly as a consequence.

More data needed on prostate cancer and men from specific ethnic groups

A review article on issues affecting perceptions of prostate cancer among Black men of African, Afro-Caribbean, and African American ethnicity has highlit the very limited data available about prostate cancer, its diagnosis, and its management in males from specific ethnic groups inside and outside the USA.

Does eribulin mesylate have potential in mCRPC … or not?

In May 2010 we reported that a product called eribulin mesylate had been tested (in the USA) in a Phase II clinical trial for its activity in metastatic, castration-resistant prostate cancer (mCRPC) — and that the results were not particularly promising.

Registry initiative now holds data on > 500 CyberKnife patients

A multi-institutional “Registry for Prostate Cancer Radiosurgery” (RPCR) was initially set up in July 2010 to track clinical and functional outcomes of men with localized prostate cancer treated with the CyberKnife stereotactic body radiation therapy system (SBRT) at academic and community-based centers throughout the U.S.

New options after standard hormone therapy has failed

We apparently managed to overlook a series of three review and commentary articles published in Oncology in May this year that dealt with the evolving options that have already — or will soon — come available for the treatment of castration-resistant prostate cancer (CRPC).

Selenium in treatment of men with HG-PIN to prevent prostate cancer

The SELECT study has previously shown that treatment with selenium did not prevent prostate cancer in your average “guy in the street.” However, what about men with a prior diagnosis of high-grade prostatic intraepithelial neoplasia (HG-PIN)?

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