Aflibercept fails to extend survival of men with mCRPC in pivotal Phase III trial


Not entirely surprisingly, in a joint media release from Regeneron Pharmaceuticals and Sanofi issued yesterday, the two companies have announced that the investigational agent aflibercept did not extend overall survival in combination with docetaxel and prednisone in the randomized Phase III VENICE trial.

The randomized, double-blind, multi-national, Phase III VENICE study (VEGF Trap Administered with Docetaxel in metastatic androgen-independent prostate cancer) was designed to compare the efficacy and safety of aflibercept (also known as Zaltrap®) in combination with docetaxel and prednisone to a placebo + docetaxel + prednisone in men with metastatic, castration-resistant prostate cancer (mCRPC). A total of 1,224 patients with mCRPC were randomized to receive one or other of the two regimens.  The primary study endpoint was an improvement in overall survival. Secondary endpoints included effects on PSA levels, pain, and progression-free survival.

According to the media release, Regeneron and Sanofi “are conducting a detailed analysis of the VENICE data, and full results will be presented at an upcoming medical meeting.” However, it seems unlikely that any further investment will be made in aflibercept as a potential treatment for advanced forms of prostate cancer.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Follow

Get every new post delivered to your Inbox.

Join 1,122 other followers