In February we reported on a presentation by Sheets et al. at the Genitourinary Cancer Symposium. The presentation addressed the comparative effectiveness and safety of 3D conformal, intensity-modulated, and proton beam forms of radiation therapy (3D-CRT, IMRT, and PBRT, respectively).
The full, peer-reviewed data from this study have now been published in the Journal of the American Medical Association (JAMA). The data published by Sheets et al. continue to suggest that:
- IMRT was the most widely used form of radiation therapy in the management of prostate cancer in 2008.
- Prostate cancer patients treated with IMRT as compared to 3D-CRT were
- Less likely to have gastrointestinal morbidities post-radiation
- Less likely to have fractures of the hip post-radiation
- More likely to have erectile dysfunction post-radiation
- Less likely to need additional cancer therapy
- Prostate cancer patents treated with PBRT as compared to IMRT were
- More likely to have gastrointestinal morbidity post-radiation
A commentary on this article on the Reuters web site carries third-party views on this article from a number of different specialists. As yet, however, we have seen no refutation of or other commentary about these data from any member of the PBRT community.