Finally … Some long-term functional outcomes data on first-line treatment

An article in this week’s New England Journal of Medicine offers us 15-year functional outcomes data from the Prostate Cancer Outcomes Study (PCOS), which enrolled 3,533 men in whom prostate cancer was diagnosed in 1994 or 1995. … READ MORE …

MRI-guided focused ultrasound in focal treatment of low-risk, localized prostate cancer

In October last year, the US Food and Drug Administration approved the ExAblate MRI-guided focused ultrasound technology for the treatment of pain associated with cancer metastasis to bones, which is obviously a potential benefit for men with late stage, metastatic prostate cancer. … READ MORE …

Age, hair loss, and risk for prostate cancer diagnosis

An excellent commentary on the NHS Choices web site addresses an article by an Australian research team showing that men who show signs of baldness by age 40 are at heightened risk for a diagnosis of prostate cancer, but that this is not the case at older ages. The risk of having prostate cancer at > 76 years old was about 15 percent in this study, regardless of hair loss at 40. … READ MORE …

Risk for biochemical failure post-surgery among prostate cancer patients > 70 years of age

A new article from the clinical research group at The Cleveland Clinic has suggested that men > 70 years of age are at significantly higher risk for recurrence of their prostate cancer if treated by radical prostatectomy than younger men with comparable diagnostic criteria. … READ MORE …

Of cow’s milk, doughnuts, fried chicken, and other important food groups

Two recent articles have linked certain dietary habits to risk for development of prostate cancer. The degree to which one feels that these dietary habits may be “proven” to increase risk for prostate cancer is probably going to be debatable; the existence of a potential link is certainly clear. … READ MORE …

Immediate, adjuvant ADT after surgery does not significantly affect survival of high-risk men

For many years, physicians at the Mayo Clinic in Rochester, MN, have been offering immediate, adjuvant androgen deprivation therapy (ADT) to some of their surgical patients with more advanced and high-risk forms of prostate cancer. The assumption had been that early use of ADT among such patients might have a significant survival benefit. … READ MORE …

Diagnosis of prostate cancer in UK projected to be more common

According to a report in today’s Daily Telegraph, Cancer UK is projecting a significant increase in risk for a diagnosis of prostate cancer in the United Kingdom over the next 50 to 60 years. … READ MORE …

Over-inflation of the significance of PSA velocity in Kaiser paper

We still haven’t been able to see the full text of the article by Wallner et al. (reported yesterday) suggesting that PSA velocity was as good or better than a single PSA data point in predicting risk for prostate cancer — and for aggressive types of prostate cancer in particular. However, … READ MORE …

More on the hypothetical potential of focal therapy for prostate cancer

A new article (available in full text) discusses the hypothetical potential of focal therapy as a form of treatment that “bridges the gap” between active surveillance and whole gland surgery or whole gland ablation for men with small amounts of early stage cancer that is entirely confined to their prostates. … READ MORE …

Estimated prostate cancer cases/deaths in USA in 2013

According to the newly published report, “Cancer statistics, 2013,” now available in the journal CA: A Cancer Journal for Clinicians, prostate cancer will become the most commonly diagnosed cancer of any type in the USA this year. … READ MORE …

PSA velocity and risk for clinically significant prostate cancer

Analysis of data from > 200,000 men, all enrolled in a large California managed care health plan, appears to offer us some “insight into the usefulness of PSA velocity as a detection marker for aggressive prostate cancer.” … READ MORE …

Prostate Cancer Roundtable updates policy agenda for 2013

The Prostate Cancer Roundtable has announced an update to its policy agenda for 2013, concurrent with the start of the work of the new Congress here in the USA. … READ MORE …

Does type of exercise affect HRQoL in men on ADT for prostate cancer?

A newly published study in the Journal of Aging and Physical Activity has examined the differing effects of two types of exercise on the health-related quality of life (HRQoL) of men with prostate cancer who are being treated with androgen deprivation therapy (ADT). … READ MORE …

Why 5 years to publish the outdated results of a survey on screening?

According to an new article just published in the Annals of Family Medicine, 24.6 percent of family physicians ordered PSA tests for male patients without any discussion about the harms and benefits of this test. We don’t find this a particularly surprising statistic. … READ MORE …

Docetaxel rejected in first-line treatment of androgen-sensitive, metastatic prostate cancer

It has long been an open question whether early chemotherapy might benefit selected patients with androgen-sensitive prostate cancer. However, many trials seeking to answer this question have been unable to enroll sufficient patients to provide meaningful answers to this question. … READ MORE …

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