Olaparib continues to show promise in very late stage prostate cancer

According to a presentation at the ongoing annual meeting of the American Association for Cancer Research (AACR) meeting here in  Philadelphia, AstraZeneca’s PARP inhibiting agent — olaparib or Lynparza — continues to show promise in very late stage metastatic, castration-resistant prostate cancer. … READ MORE …

Active surveillance today: a summary of the Sunnybrook experience and related factors

In an important new paper in Current Opinion in Urology (available free as a full-text article), Dr. Laurie Klotz has provided an excellent summary of his perspective on the current application of active surveillance in the management of low-risk prostate cancer, based on the 20-year experience of the Sunnybrook group and other data. … READ MORE …

But one OTC supplement prevents, treats prostate cancer successfully (in mice)

Having pointed out (again) that over-use of many dietary supplements can increase risk for cancer (prostate cancer included), we felt it only fair to also point out that some recent data suggest than one over-the-counter (OTC) dietary supplement seems to have the opposite effect on prostate cancer … in laboratory mice. … READ MORE …

Just how helpful is personalized genomic analysis anyway?

Regular readers of the medical science literature will be very conscious of the emphasis on genomic analysis of tumor specimens as a way to try to “personalize” treatment of cancers of many types — prostate cancer very specifically included. … READ MORE …

The monitoring of men with localized prostate cancer after first-line treatment

An article just posted in the journal Oncology offers readers a concise summary of the appropriate follow-up monitoring for men after initial, definitive treatment for localized prostate cancer who show no signs of progressive disease over time. … READ MORE …

PSMA ADC in treatment of mCRPC post-chemo and post-abiraterone and/or enzalutamide

Data from an open-label Phase II trial of PSMA ADC — a fully human IgG1 antibody conjugated to monomethyl auristatin E (MMAE) — suggests that this agent has activity in treatment of metastatic, castration-resistant prostate cancer (mCRPC) patients who have already progressed on abiraterone acetate and/or enzalutamide. … READ MORE …

Does sequencing of therapy affect outcomes of treatment with sipuleucel-T + ADT in high-risk disease?

We still have very little knowledge about whether early prostate cancer immunotherapy with sipuleucel-T (Provenge) or other forms of immunotherapy might be beneficial in the management of patients with high-risk prostate cancer. … READ MORE …

Follow

Get every new post delivered to your Inbox.

Join 1,261 other followers