Radiation therapy may improve survival even when PSA ≥ 75 ml/ml

Sometimes, when patients originally present with very high PSA levels, a negative bone scan, and a negative CT scan, they are put on permanent androgen deprivation  therapy (ADT) because the doctor just assumes it is micrometastatic. … READ MORE …

Active surveillance under-used (back in 2010-2011)

A new research letter just published in JAMA Internal Medicine suggests that only about 12 percent or less of the men who are good candidates for active surveillance are actually being managed in that manner. But, … READ MORE …

Tokai initiates trial of galeterone in men with AR-V7-positive mCRPC

According to information released earlier today by Tokai Pharmaceuticals, the company has started to enroll patients with AR-V7-positive, metastatic, castration-resistant prostate cancer (mCRPC) into a randomized Phase III clinical trial of treatment with galeterone. … READ MORE …

Should all patients starting on ADT be on a statin too?

A newly published article in JAMA Oncology has now suggested that adding a statin to a patient’s treatment regimen at initiation of androgen deprivation therapy (ADT) may significantly impact time to disease progression among men diagnosed with progressive, hormone-sensitive prostate cancer. … READ MORE …

Does diagnosis/treatment for prostate cancer increase risk for colorectal cancer too?

A newly published study in the journal of Cancer Control has again suggested the possibility that men treated for prostate cancer may be at elevated risk for a secondary diagnosis of colorectal cancer by comparison with similar men never diagnosed with prostate cancer. … READ MORE …

Astellas, Medivation initiate TRUMPET registry study

Many patients newly diagnosed with castration-resistant prostate cancer (CRPC) may be interested in participating in a new registry study known as the TRUMPET study, which has just started to enroll patients and is sponsored by Astellas and Medivation (the developers and marketers of enzalutamide/Xtandi). … READ MORE …

Major trial confirms value of zoledronic acid dosed every 3 months in preventing pain, SREs

An interesting paper that we managed to miss at the recent annual meeting of the American Society of Clinical Oncology (ASCO) provided the results of a large, randomized clinical trial of the use of zoledronic acid, carried out by the Cancer and Leukemia Group B cooperative trial group. … READ MORE …

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