IAD vs. CAD in men with hormone-sensitive, metastatic prostate cancer

Today at the ASCO annual meeting, Maha Hussein presented the results a long-term, international, randomized trial of intermittent androgen deprivation (IAD) versus continuous androgen deprivation (CAD) in men with hormone-sensitive, metastatic prostate cancer.

Key presentations at ASCO today on advanced prostate cancer

The key prostate cancer presentations today at the annual meeting of the American Society of Clinical Oncology (ASCO) were all given at a morning session on high-risk and advanced prostate cancer.

Abiraterone acetate in chemotherapy-naive mCRPC — Phase III trial outcome

This morning, at the ASCO annual meeting, Dr. Charles Ryan will present the full interim results of COU-AA-302, the randomized, Phase III study of abiraterone acetate in chemotherapy-naive patients with metastatic, castration-resistant prostate cancer (mCRPC).

Two important new trials of enzalutamide and cabozantinib for patients with mCRPC

According to media releases from the relevant companies, two significant trials (of enzalutamide and of cabozantinib) are already or will soon be recruiting men with metastatic, castration-resistant prostate cancer (mCRPC).

Effects of ketoconazole, abiraterone, and chemotherapy in men with CRPC

Studies to be presented at the ASCO meeting next week suggest that: (a) high-dose ketoconazole has very limited activity in the treatment of men who have already been treated with abiraterone acetate; (b) men treated with either high-dose ketoconazole or abiraterone acetate (or both) can still respond to docetaxel-based chemotherapy.

Managing advanced prostate cancer: what’s going to be presented at ASCO

So there are going to be > 180 papers specific to the management of prostate cancer presented at the annual meeting of the American Society of Clinical Oncology (ASCO) starting in Chicago next weekend. Some will be trivial; several will be “interesting”; a very few will be important.

Active surveillance in the “real world” of clinical practice today

A poster to be presented at the upcoming ASCO annual meeting gives us some insights into the actual behaviors of physicians and their patients regarding the use of active surveillance today in the “real world” of clinical practice (as opposed to clinical trials and case series at academic medical centers).

Prostate cancer “spread through the air” … NOT!

How did we all miss this? This may be the single most important paper presented at the annual meeting of the American Urological Association this year!

GUMDROP — or how some specialists collaborate to help their patients

An article in The Washington Post today discusses an initiative through which a group of about 40 specialists in the management of advanced forms of genitourinary cancers (including prostate cancer) get together to share ideas and knowledge to help their patients.

Death of al Megrahi — but was it of prostate cancer at all?

Acccording to an article on the Medscape web site today, the convicted “Lockerbie bomber,” Abdelbaset al Megrahi, finally died on Sunday, 2 years and 9 months after his release from a Scottish prison on compassionate grounds because he was close to dying of terminal prostate cancer.

Update on Phase III trial of tasquinimod in mCRPC

According to a media release issued this morning by Active Biotech and Ipsen, the companies have already enrolled 600 out of the 1,200 men with metastatic, castration-resistant prostate cancer (mCRPC) needed to complete the randomized, double-blind Phase III clinical trial of tasquinimod.

Living through chemotherapy (if you have to have it)

There is a “nice” post today about surviving chemotherapy on Dr. Craig Hildreth’s cancer blog on the CancerNetwork.com web site. (“Nice” is in inverted commas because not much about chemotherapy is actually nice … but if you, your oncologist, and the oncologist’s office team think about chemo in the way Dr. Hildreth describes, it sure [...]

Hospital volume important to outcomes among older, sicker, Medicare patients treated by RP

A media release issued by Henry Ford Health System earlier today has a distinctly misleading headline that reads as follows: “Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery.” You need to read the content of the media release with care to understand that this headline is by no means [...]

NICE issues new and positive draft guidance on abiraterone acetate

According to information on the web site of the National Institute for Clinical Excellence (NICE), revised draft guidance has been issued by NICE regarding the routine use of abiraterone acetate.

Abiraterone acetate may help to eliminate cancer prior to surgery in some men with high-risk, localized disease

According to the abstract of a paper to be presented at the upcoming meeting of the American Society for Clinical Oncology in Chicago at the beginning of June, 24 weeks of treatment with neoadjuvant abiraterone acetate + prednisone + an LHRH agonist appears to be able to eliminate visible risk of prostate cancer in post-surgical [...]

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