Active surveillance in the “real world” of clinical practice today

A poster to be presented at the upcoming ASCO annual meeting gives us some insights into the actual behaviors of physicians and their patients regarding the use of active surveillance today in the “real world” of clinical practice (as opposed to clinical trials and case series at academic medical centers).

Medivation submits NDA for MDV3100 in chemotherapy-resistant mCRPC

According to a media release issued late yesterday by Medivation and Astellas Pharma, Medivation has just submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for approval to market enzalutamide (a.k.a MDV3100).

Nothing to do with prostate cancer (yet), but …

According to an article by Andrew Pollack in today’s issue of the New York Times, a company called Osisris Therapeutics has achieved the first-ever approval to market a therapy based on stem cells — in Canada, for children with a condition known as graft versus host disease or GvHD, which is a well-recognized complication of [...]

Abiraterone acetate may help to eliminate cancer prior to surgery in some men with high-risk, localized disease

According to the abstract of a paper to be presented at the upcoming meeting of the American Society for Clinical Oncology in Chicago at the beginning of June, 24 weeks of treatment with neoadjuvant abiraterone acetate + prednisone + an LHRH agonist appears to be able to eliminate visible risk of prostate cancer in post-surgical [...]

Updated version of book on advanced prostate cancer

Malecare has just issued an updated version of its free book on recurrent and advanced prostate cancer. Many people have gained great benefit from the first edition of this book, and we are sure that the new version is equally useful.

ProstateVideos.com web site gets face-lift and update

For those who prefer to listen to their prostate cancer updates (as opposed to those that are happy to read) the video-based web site known as ProstateVideos.com has just completed a major overhaul.

Of beehive glue and mice and prostate cancer

According to a media report issued today, researchers at the University of Chicago have discovered that a product known as caffeic acid phenethyl ester or CAPE was able to stop the growth of prostate cancer tumors in a mouse model.

FDA approves avanafil — a new drug for erectile dysfunction

According to a media release from Vivus, Inc., issed late on Friday, the U.S. Food & Drug Administration has approved their PDE5 inhibitor avanafil (Stendra®) to the treatment of erectile dysfunction. However, we have to immediately point out that data on the activity of this drug in men who have been treated for prostate cancer [...]

New nanoparticle-based test may improve diagnosis of prostate cancer (in the future)

An article in the Journal of Translational Medicine (in conjunction with a media release from the University of Central Florida) has described a new test that — according to the media release — may be able to further discriminate between indolent and clinically significant forms of prostate cancer.

ASCO updates patient information on managing cost of cancer care

The costs associated with the treatment of prostate cancer — particularly the more advanced forms of prostate cancer that require sophisticated forms of drug therapy — can be considerable. Patients often benefit from help and assistance in negotiating these costs and in handling the various needs of their physicians, their insurance companies, and Medicare or even Medicaid.

LUGPA reacts to suggestions of excessive prostate biopsies in Health Affairs

Not surprisingly, a major urology organization (the Large Urology Group Practice Association or LUGPA) has aggressively disputed the findings recently published by Mitchell in Health Affairs regarding the numbers of prostate biopsies conducted by urology groups with in-house pathology laboratories (see earlier commentary).

FDA updates risks of adverse effects from treatment with finasteride

The U.S. Food & Drug Adminstration (FDA), yesterday, issued a statement about modifications to the labeling (the product prescribing information) for the two branded formulations of finasteride: Propecia® (finasteride 1 mg) and Proscar® (finasteride 5 mg). These modifications to the product labeling may be relevant to some men with or at risk for prostate cancer.

Itraconazole in treatment of mCRPC: an update

Researchers at Johns Hopkins have, for a while, been investigating the potential of the antifungal agent itraconazole as a treatment for men with metastatic, castration-resistant prostate cancer (mCRPC). We last reported on this research nearly a year ago, based on a presentation at the annual meeting of the American Society of Clinical Oncology (ASCO) in [...]

Fred Gersh … Requiescat in pace

Most readers of this column will never have heard of Fred Gersh; a few may have spoken to him or e-mailed him or actually met him. Fred passed away early this morning as a consequence of metastatic, castration- and chemotherapy-refractory disease 23 years after his initial diagnosis with prostate cancer.

Patenting of genes and related issues: Supreme Court makes two decisions

As regular readers will be aware, the Supreme Court of the United States (SCOTUS) had recently delayed any decision on a case related to the rights of Myriad Genetics to hold and enforce use patents related to the BRCA1 and BRCA2 genes associated with the diagnosis of specific subtypes of breast and ovarian cancer.

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