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First use of NOTES for radical prostatectomy

Natural orifice transluminal endoscopic surgery or NOTES refers to the conduct of minimally invasive surgery through natural orifices (like the mouth or the vagina or the nose).

Prostate cancer researcher gets major donation

Dr. David Agus — a cancer researcher at the University of Southern California’s Keck School of Medicine — must be feeling happier today, thanks to one of his former patients.

Hot from the broccoli newsfront

There’s a new media story circulating today about “important new research” related to the impact of eating broccoli on risk for prostate cancer.

Advocacy we should all aspire to …

We have mentioned Winter Vinecki once before on this web site, but newer readers may never have come across this singular young lady. If you haven’t heard her name before, you have now … and you will be hearing it some more in the future.

Finasteride, PSA doubling time, and intermittent hormone therapy

For years, some clinicians have been telling their patients to use a 5α-reductase inhibitors (5-ARIs) like finasteride or dutasteride as a form of “bridge” therapy to extend their periods of time off primary hormone therapy while being treated with intermittent hormone therapy or IHT.

New monoclonal antibody can detect ERG oncoprotein in prostate cancer patients

A media release from the Uniformed Services University of the Health Sciences last week announced the development of a highly specific assay for the detection of ERG oncoprotein. The assay is based on the development of an anti-ERG monoclonal antibody that appears to be capable of detecting the presence of ERG oncoprotein with > 99 percent accuracy.

Honoring “the owl in repose”

Every so often a wise and experienced clinician scolds us kindly for our tendency to think that every medical problem — however minor or however serious — requires urgent and aggressive action. An article by Albert Lim, MD, in yesterday’s New York Times, is perhaps relevant to Planet Prostate Cancer.

BRCA2-negative prostate cancer: new insights

New data from a research team at the Institute for Cancer Research in the UK suggest that — in men and women with a faulty BRCA2 gene — the development of breast cancer and prostate cancer follows a similar pathway.

OncoGenex starts first Phase III trial of custirsen sodium (OGX-011) in mCRPC

OncoGenex has initiated the first of two Phase III trials of custirsen sodium (OGX-011) in the treatment of men with metastatic castrate-resistant prostate cancer (mCPRC).

Prostate cancer-specific mortality rates: Afro-Caribbeans and African-Americans

At a quick glance one could get the idea from a new study that men of African ethnicity in the Caribbean were fundamentally more likely to die of prostate cancer than men of African ethnicity in the USA. However, a more careful reading of the study data suggests that this may not, really, be the case.

Better survival associated with higher doses of EBRT in higher-risk patients

It has been getting increasingly clear that elevated doses of radiation to the prostate result in better prostate cancer-specific survival for men treated with first-line radiotherapy for localized prostate cancer.

A quick update on Apoptone in hormone-refractory prostate cancer

Back in 2008 we first mentioned the initiation of clinical trials of a drug called Apoptone or HE3235 in men with hormone-refractory prostate cancer. Data on the development of Apoptone was another item on the agenda at the annual meeting of the American Society of Clinical Oncology (ASCO) earlier this week.

Does RAF gene rearrangement cause an aggressive but treatable subtype of prostate cancer?

According to a media release from the Prostate Cancer Foundation yesterday, research at the University of Michigan Comprehensive Cancer Center suggests that the RAF oncogene that drives fatal forms of melanoma (an aggressive type of skin cancer) may also drive aggressive forms of prostate cancer.

A national, proactive prostate cancer surveillance initiative

The Prostate Cancer Foundation (PCF) has announced plans for a National Proactive Surveillance Network (NPSN) designed to reduce overtreatment of prostate cancer patients to better direct resources to those patients with more aggressive, life-threatening varieties of this disease.

Another abiraterone acetate trial update

We note that the second Phase III clinical trial of abiraterone acetate — in asymptomatic or mildly symptomatic patients with metastatic, castration-resistant prostate cancer (mCRPC) who have not had either chemotherapy or ketoconazole therapy — is now fully enrolled (as of last Friday).