What’s new in the Journal of the Canadian Urologic Association?

The April issue of the Journal of the Canadian Urologic Association offers the interested reader access to the full texts of a small number of topical articles. None of them could be considered “game changing” in terms of current prostate cancer management today … but certainly thought-stimulating.

Adjuvant degarelix in combination with radiation therapy (instead of an LHRH agonist + an antiandrogen)

According to an announcement from the European Association for Urology (EAU) earlier today, data from a recently completed trial demonstrate that degarelix is “non-inferior” to the LHRH agonist goserelin acetate + the antiandrogen bicalutamide at reducing prostate volume in men with advanced hormone- dependent prostate cancer.

Adjuvant or salvage radiation for high-risk patients post-surgery? The need for shared decision-making

In the October issue of European Urology there was an interesting “consensus statement” about the role of radiation therapy as adjuvant or salvage therapy for men who are at significant risk for recurrence of their prostate cancer after first-line treatment with radical prostatectomy.

Adjuvant radiation + ADT after surgery for SV+ prostate cancer

A new study just published in BJU International offers data suggesting the idea that all men found to have positive seminal vesicles (SV+) after radical prostatectomy should receive immediate adjuvant treatment with external beam radiation and  androgen deprivation therapy (ADT).

Immediate adjuvant therapy for men with positive surgical margins after RP

There are no absolute guidelines as to which patients who have positive surgical margins after a radical prostatectomy (RP) are most appropriate for immediate adjuvant radiation therapy (with or without neoadjuvant and/or adjuvant hormone therapy).

Results of RTOG 94-08 finally published in NEJM

As we first reported in March 2010, when data were originally presented at the Genitourinary Cancers Symposium, RTOG 94-08 has shown that 4 months of androgen deprivation therapy (ADT) before and during external beam radiation therapy (EBRT) reduces the overall and the prostate cancer-specific mortality rates for men with localized prostate cancer (clinical stages T1b, [...]

What different specialists believe about adjuvant radiation therapy

A recent study published in “The Red Journal” suggests (perhaps not surprisingly) that radiation oncologists and urologists have different mindsets about the application of immediate adjuvant radiation therapy following surgery for prostate cancer patients with a variety of adverse pathologic risk factors.

Adjuvant ADT after surgery in men with high-risk prostate cancer

Back in June 2010, we reported on the initial results of SWOG 9921 — a trial that randomized 983 men with high-risk features at prostatectomy to receive adjuvant therapy with androgen deprivation (ADT) alone or in combination with mitoxantrone chemotherapy.

A “last word” from the Genitourinary Cancers Symposium

Over 200 posters and other presentations of new data, as well as many other discussions and lectures, were offered yesterday in the prostate cancer sessions at the Genitourinary Cancers Symposium in Orlando.

Limited value of immediate, adjuvant ADT in men with pT3b prostate cancer

New data published by clinical researchers at the Mayo Clinic have suggested that there is no overall survival benefit associated with adjuvant hormone therapy after surgery in men with pathological T3b disease.

Evaluating the need for immediate, adjuvant radiation therapy after surgery

Men with high-risk, localized prostate cancer who decide on surgery as their first-line treatment of choice are sometimes faced with the question of whether to undergo “immediate” adjuvant radiation therapy after their surgery or to do nothing and wait to see if salvage radiation therapy becomes necessary.

Immediate adjuvant radiation therapy in the pT3 patient post-surgery

In March 2009, Thompson et al. published data from the SWOG 8794 trial showing that adjuvant radiation therapy immediately post-surgery significantly improved the oncologic outcomes of men with pathologic T3N0M0 prostate cancer compared to later salvage radiation, but

Does local therapy with ADT for locally advanced prostate cancer improve patient outcomes?

The use of androgen deprivation therapy (ADT) is at the heart of treatment for patients with advanced forms of prostate cancer. What has been debated for years, however, is when, for how long, and in combination with what other forms of therapy ADT should be applied.

A fly in the ointment of RT + adjuvant ADT

Over the years, several randomized trials have shown the benefit of combining androgen deprivation therapy (ADT) with radiation therapy (RT) for the first- and second-line treatment of men with prostate cancer. However,

Adjuvant chemotherapy + ADT in high-risk patients after surgery

A number of trials are currently evaluating the potential value of adjuvant chemotherapy after first-line treatment in men with high-risk prostate cancer. The effects of this form of treatment on long-term outcomes still to be established, but …

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