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As many readers of this news service will be aware, good data on the recovery of libido and sexual function after a period of androgen deprivation therapy (ADT) are limited. We have long known that such recovery is variable, and we also know that it can take time, but sound data from a large cohort [...]
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation, function, libido, masculinity, potency, serum, sex, testosterone | 4 Comments »
A new review published recently in the British Journal of Cancer addresses appropriate current practice regarding the use of neoadjuvant and adjuvant androgen deprivation therapy (ADT) in combination with radiation therapy in the management of patients with high-risk localized and locally advanced forms of prostate cancer.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: "high risk", ADT, androgen deprivation, localized, locally advanced, outcomes, radiation therapy, survival | 4 Comments »
An article just published in the journal Cancer has reported an association between the use of androgen deprivation therapy (ADT) and risk for blood clots among men being treated for prostate cancer.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation, blood clot, hormone, risk, thromboembolism | 9 Comments »
A new report in Lancet Oncology offers guidance on which patients with prostate cancer who are initially treated with radiotherapy and 6 months of neoadjuvant androgen deprivation therapy (ADT) are at relatively high and relatively low levels of risk for prostate cancer-specific mortality.
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: ADT, androgen deprivation, cancer-specific, marker, mortality, neoadjuvant, progression, PSA, radiation, surrogate | 2 Comments »
The big news today is the publication, in The Lancet, of the interim results of the NCIC CTG PR.3/MRC UK PR07 trial, originally presented by Warde et al. at the annual meeting of the American Society for Clinical Oncology in June 2010 and then by Mason et al. at the annual meeting of the American [...]
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: "high risk", ADT, androgen deprivation therapy, EBRT, external beam radiation therapy, localized, locally advanced | Leave a Comment »
A newly published article in BJU International offers data from a small, randomized, pilot study of the use of metformin and lifestyle changes in the prevention of cardiovascular morbidity and androgen deprivation therapy (ADT)-related metabolic syndrome.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation, exercise, metformin, outcome | Leave a Comment »
A new study just published in BJU International offers data suggesting the idea that all men found to have positive seminal vesicles (SV+) after radical prostatectomy should receive immediate adjuvant treatment with external beam radiation and androgen deprivation therapy (ADT).
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: adjuvant, ADT, androgen deprivation, positive, radiation therapy, seminal vesicle | 21 Comments »
Initially, androgen deprivation therapy (ADT) was conceived of and developed as long-term, palliative therapy for men with evident and commonly painful forms of metastatic prostate cancer. The primary goal was the alleviation of pain associated with metastasis, and had little or nothing to do with the patient’s long-term survival.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation, internittent, therapy | 4 Comments »
Clinical guidelines issued by the National Comprehensive Cancer Network recommend that prostate cancer patients being treated with androgen deprivation therapy (ADT) — either alone or in combination with radiation therapy — should be screened for osteoporosis and treatment to prevent deterioration of bone health associated with a decline in bone mineral density.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation therapy, DXA, fracture, FRAX, guideline, osteopenia, osteoporesis, Prevention | 4 Comments »
The question of whether an LHRH antagonist (such as degarelix) is really a better first-line hormone therapy than an LHRH agonist (e.g., leuprolide acetate) is still not fully answered.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, agonist, androgen deprivation, antagonist, Degarelix, leuprolide, LHRH | Leave a Comment »
The addition of androgen deprivation therapy (ADT) to radiation therapy for men with localized prostate cancer is common. It may be used to reduce the size of the prostate prior to brachytherapy or for longer periods in men with higher risk disease to extend survival (which has been demonstrated in large-scale, randomized, multi-center clinical trials).
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: ADT, androgen deprivation therapy, brachytherapy, cardiovascular disease, history, mortality, radiation, risk | 4 Comments »
As we first reported in March 2010, when data were originally presented at the Genitourinary Cancers Symposium, RTOG 94-08 has shown that 4 months of androgen deprivation therapy (ADT) before and during external beam radiation therapy (EBRT) reduces the overall and the prostate cancer-specific mortality rates for men with localized prostate cancer (clinical stages T1b, [...]
Filed under: Management, Treatment | Tagged: adjuvant, ADT, androgen deprivation, EBRT, mortality, neoadjuvant, outcome, radiation therapy, RTOG 94-08 | Leave a Comment »
White race and low bone mineral density (osteoporosis) appear to be the only two of a dozen different potential risk factors that significantly increase the likelihood of vertebral (spinal and hip) fractures among men being treated with androgen deprivation therapy (ADT) for prostate cancer.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation, fracture, risk, vertebral | 1 Comment »
So-called “hot flashes” are a common and annoying side effect of androgen deprivation therapy for many men with high-risk and advanced forms of prostate cancer. A new study has suggested that an extract of common, garden sage (Salvia officinalis) may be an effective dietary supplement that can significantly lower frequency and intensity of hot flashes.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation, extract, hot flashes, sage, Salvia officinalis | 1 Comment »
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