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A new paper in the Proceedings of the National Academy of Sciences suggests the existence of a subset of “hypermutated” cell lines in some forms of aggressive prostate cancer.
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, genetics, hypermutation, mutation, variants | Leave a Comment »
The idea that one’s diet may affect one’s risk for prostate cancer in general — or perhaps for one’s risk of more aggressive forms of prostate cancer — is not exactly new.
Filed under: Diagnosis, Prevention, Risk | Tagged: aggressive, carotenoid, Diagnosis, diet, glycemic index, leafy, risk, vegetables | 3 Comments »
A newly published article, available on-line in the journal Prostate Cancer and Prostatic Diseases, shows that tissues from prostate biopsies from black men express higher levels of biomarkers for aggressive disease than do tissues from prostate biopsies taken from white men.
Filed under: Diagnosis, Risk | Tagged: aggressive, biomarker, black, risk, white | Leave a Comment »
A team of researchers at the University of Michigan Comprehensive Cancer Center are claiming that they have identified an important target that may lead to the development of effective treatments for one aggressive type of prostate cancer. The target is a gene called SPINK1.
Filed under: Diagnosis, Risk | Tagged: aggressive, Diagnosis, gene, risk, SPINK1 | 2 Comments »
A new report just published on line in Lancet Oncology is suggesting that the cell cycle progression (CCP) score — a measure of the levels of expression of selected genes that are important to cell growth — may be an important indicator of risk for more aggressive types of prostate cancer.
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, CCP, cell cycle progression, prognosis, PROLARIS, score | Leave a Comment »
A re-analysis of data from the Antwerp (Belgium) section of the European Randomized Study of Screening for Prostate Cancer (ERSPC) has offered us some further insight into the frequency of PSA testing necessary to identify less and more aggressive forms of prostate cancer.
Filed under: Diagnosis, Risk | Tagged: aggressive, interval, PSA, risk, screening, test | 5 Comments »
Long-term follow-up data have just been published from two studies designed to provide preliminary information on the potential use of very aggressive forms of treatment in men with high-risk categories of prostate cancer.
Filed under: Management, Treatment | Tagged: aggressive, androgen deprivation, docetaxel, hormone, paclitaxel, radiation, taxane, therapy | 7 Comments »
A paper to be presented on Sunday at the upcoming annual meeting of the American Association for Cancer Research suggests that “the proliferative index as assessed by Ki-67 immunoreactivity is an independent predictor of aggressive prostate cancer.”
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, differentiation, indolent, Ki-67, marker, prognosis | 2 Comments »
Another new article in the Proceedings of the National Academy of Sciences has suggested the possibility of major progress in the prostate cancer research field — but at least this time the media seem to have got the story right!
Filed under: Diagnosis, Risk | Tagged: aggressive, association, gene, grade, indolent, variant | Leave a Comment »
A new paper by Wang et al. in a recent issue of Cancer Research has proposed details of a specific connection between control over the growth and division of prostate cancer cells and clinical occurrence of the more aggressive forms of prostate cancer.
Filed under: Management, Risk | Tagged: aggressive, cell, indolent, messenger RNA, microRNA, regulation | 3 Comments »
Researchers associated with the Duke Prostate Cancer have re-calibrated an older nomogram (used to predict the likelihood of biochemical recurrence after a radical prostatectomy or RP). The revised nomogram is now capable of predicting not only biochemical recurrence but also the much more clinically significant risk for an aggressive recurrence — in which the post-surgical [...]
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: aggressive, biochemical recurrence, PSA doubling time, PSADT, radical prostatectomy, surgery | Leave a Comment »
Yesterday we reported a study suggesting the potential of hyalouronidase staining as a method to differentiate between aggressive and indolent prostate cancers at the time of diagnosis. Now a report in the British Journal of Cancer suggests that heat shock protein 27 (Hsp-27) may also have this potential.
Filed under: Diagnosis, Risk | Tagged: aggressive, heat shock protein, Hsp-27, risk | Leave a Comment »
There have been frequent suggestions over the years that specific viruses may be implicated in the development of certain types of cancer, and an article in this week’s Proceedings of the National Academy of Science discusses the possibility that this may be the case in aggressive forms of prostate cancer.
Filed under: Diagnosis, Risk | Tagged: aggressive, virus, XMVR | Leave a Comment »
Now after you have read this, we do not think you should be rushing out to fill your medicine cabinet with vitamin A. We need more research to validate the results of this study, but …
Filed under: Prevention | Tagged: aggressive, Prevention, vitamin A | 2 Comments »
Additional, non-ASTRO-related news today includes the following: Screening, treatment, and mortality in Medicare-eligible populations Genetic variants and relationships to clinical and pathological variables The application of MRI in prostate cancer management Predictors of aggressive biochemical recurrence after radical prostatectomy
Filed under: Management, Treatment | Tagged: aggressive, genetic variants, magnetic resonance, mortality, MRI, prediction, recurrence | Leave a Comment »
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