The natural history of biochemical recurrence after surgery

It has been well understood for years that biochemical recurrence (BCR) after radical prostatectomy does not always translate into systemic progression or necessarily lead to prostate cancer metastasis and death. The “natural history” of BCR is actually very variable. … READ MORE …

Second study confirms data on PSADT and survival post-surgery

In 2009, at a presentation at the American Society for Clinical Oncology, Antonorakis et al. initially presented data, from the Johns Hopkins database, demonstrating the prognostic significance of PSA doubling time (PSADT) to long-term survival of men with progressive prostate cancer who were otherwise untreated after surgery. … READ MORE …

Prostate cancer-specific mortality after biochemical recurrence in a cohort of US veterans

A study reported this week in the Archives of Internal Medicine addresses the impact of biochemical recurrence on risk for prostate cancer-specific mortality (PCSM) among a cohort of more than 1,000 US veterans initially diagnosed and treated between 1991 and 1995. … READ MORE …

The value of second-line treatment for men with biochemical recurrence

Biochemical failure (also known as biochemical recurrence) after first-line treatment for prostate cancer is assessed based on a rising PSA level. This is a relatively common event and can happen shortly after first line treatment or many years later. The problem is that we really don’t know how important biochemical recurrence is in an individual patient at a specific point in time. After all, if a biochemical recurrence is never going to lead to clinical symptoms of prostate cancer (let alone prostate cancer-specific mortality), why would one want to treat it? … READ MORE …

Biochemical recurrence after RP and risk of mortality

A recent report in Cancer again seems to suggest that men with prostate cancer treated by radical prostatectomy (RP) who have a long time to biochemical recurrence (BCR) or a long PSA doubling time after BCR may have no higher overall risk of death than men who have no BCR at all. … READ MORE …

Prostate cancer news reports: Wednesday, January 27, 2010

In today’s new reports we summarize information from recent papers dealing with:

  • Apical biopsy cores in initial diagnosis of prostate cancer
  • Imaging studies in the initial work-up of newly diagnosed patients
  • Intrafascial dissection of peri-prostatic tissue during laparoscopic surgery
  • Similarity of short-term rates of biochemical recurrence after open surgery or RALP
  • Does how we define post-surgical biochemical recurrence matter — and if so, when? … READ MORE …

New nomogram can predict aggressive recurrence after RP

Researchers associated with the Duke Prostate Cancer have re-calibrated an older nomogram (used to predict the likelihood of biochemical recurrence after a radical prostatectomy or RP). The revised nomogram is now capable of predicting not only biochemical recurrence but also the much more clinically significant risk for an aggressive recurrence — in which the post-surgical PSA doubling time (PSADT) is < 9 months. … READ MORE …

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