What to make of a PCA3 score of ≥ 100

Some studies (e.g., this one by Roobol et al.) have previously indicated that not all men with very high prostate cancer antigen 3 (PCA3) scores are necessarily found to have prostate cancer on biopsy or re-biopsy. … READ MORE …

Let’s compare the media hype to the actual data (about MR-guided biopsy)

According to an article online in The Australian today, “Men won’t need to have numerous painful needles in their rectum to find out if they have prostate cancer anymore”. … READ MORE …

New NCCN guidelines on prostate cancer are not an all-around success!

Alas, the latest revisions to the National Comprehensive Cancer Network (NCCN) guidelines on early detection of prostate cancer seem to have instigated more furore than they have clarity (although the original premise behind them may have been well intentioned). … READ MORE …

Statins and risk for diagnosis of prostate cancer … a not so small surprise

A recently published article in Prostate Cancer and Prostatic Diseases has suggested (again) that statin therapy can decrease risk for a diagnosis of prostate cancer … but this new article comes with a special twist in the tail …. … READ MORE …

PCA3 density as a marker for prostate cancer risk?

Regular readers will be aware that a PSA density (i.e., PSA ÷ prostate volume) > 0.15 has been identified and characterized as a risk factor for clinically significant prostate cancer by researchers at Johns Hopkins. … READ MORE …

Diagnosis of prostate cancer with an “eNose”: is this real?

For those of you who remember media reports and scientific papers showing that some cancers (prostate cancer included) could be detected, albeit with limited consistency, in urine samples by trained dogs … yes, this is now getting closer to real. … READ MORE …

Improving diagnosis, prognosis, and treatment decision-making

Whatever one’s views on the relative merits of mass screening or carefully targeted, risk-based testing, there is little doubt that we need to do better in deciding who to biopsy once prostate cancer is suspected and who to treat when it is identified. … READ MORE …

Risk evaluation among men initially diagnosed with T1cN0M0 disease

A recent paper in Frontiers in Oncology offers us new information about the risk profiles of men initially diagnosed with clinical stage T1c disease in the USA in relatively recent years. … READ MORE …

Diet, nutrition, place, and risk for prostate cancer

A newly published paper in the journal Nutrients doesn’t tell us anything really new about the likely correlations between nutrition and risk for prostate cancer, but it does offer us some interesting information about the time frame over which such correlations may take effect. … READ MORE …

Can we accurately project risk for over-diagnosis and over-treatment?

There is an interesting new article just published in the Journal of the National Cancer Institute describing a nomogram designed to estimate risk for over-diagnosis of men diagnosed with prostate cancer. … READ MORE …

Genomics, prostate cancer, and biomarker development

A number of readers may be interested in an article by Yadav et al. in the January issue of AUA News, entitled “Genomics at the forefront of biomarker development for prostate cancer detection and therapeutics.” … READ MORE …

Pre-diagnostic aspirin use and prostate cancer-related mortality

An article just published in Renal & Urology News states that “Men who take aspirin doses above 75 mg have a significantly reduced risk of death from prostate cancer … compared with men who do not take aspirin.” … READ MORE …

No decrease in mortality rate of newly diagnosed men with metastatic prostate cancer

A newly published paper in the journal Cancer has indicated that, here in the USA, although overall prostate cancer mortality has declined by ~ 40 percent during the past 25 years, there has been no significant decrease in the mortality rate among men who have evident metastatic prostate cancer at time of diagnosis. … READ MORE …

EAU updates guidelines on screening, diagnosis, and management of localized prostate cancer

The European Association of Urology (EAU) has just updated its guideline document “EAU guidelines on prostate cancer. Part 1: Screening, diagnosis, and local treatment with curative intent”. … READ MORE …

Does statin therapy really extend survival of men diagnosed with prostate cancer?

An analysis of another large cohort of prostate cancer patients (this time from the United Kingdom) has again suggested that there is a reduction in the risk of prostate cancer-specific mortality for patients who are treated with statins after their initial diagnosis with prostate cancer. … READ MORE …

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