EBRT + total (combined) ADT in treatment of high-risk, localized and locally advanced prostate cancer

Posted on November 3, 2011 by Sitemaster

The big news today is the publication, in The Lancet, of the interim results of the NCIC CTG PR.3/MRC UK PR07 trial, originally presented by Warde et al. at the annual meeting of the American Society for Clinical Oncology in June 2010 and then by Mason et al. at the annual meeting of the American [...]

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All the different types of external beam radiation therapy for prostate cancer: a good introduction

Posted on September 17, 2011 by Sitemaster

Over the past 20 years there has been an explosion in the different ways that we use varied types of external beam radiation therapy for the treatment of localized and locally advanced forms of prostate cancer. Where is the newly diagnosed patient able to find a good, basic introduction?

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A new way to look at side effects of first-line prostate cancer treatment

Posted on August 26, 2011 by Sitemaster

Academic research into the side effects of different treatments for localized prostate cancer have long been hampered by the lack of consistently used criteria for the assessment of those side effects at baseline and at defined time-periods post-treatment.

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Further experience with salvage HIFU after first-line EBRT

Posted on August 16, 2011 by Sitemaster

A second, small study has now offered additional data on clinical experience of the use of high-intensity focused ultrasound (HIFU) as a form of salvage therapy in men initially diagnosed with localized prostate cancer, but with a rising PSA after external beam radiation therapy (EBRT) as their first-line treatment.

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Health-related QOL after salvage HIFU for recurrent, localized prostate cancer

Posted on August 12, 2011 by Sitemaster

Men with locally recurrent prostate cancer after first-line external beam radiation therapy (EBRT) have historically had three options for second-line treatment: salvage radical prostatectomy, salvage cryoablation, and salvage brachytherapy.

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Results of RTOG 94-08 finally published in NEJM

Posted on July 14, 2011 by Sitemaster

As we first reported in March 2010, when data were originally presented at the Genitourinary Cancers Symposium, RTOG 94-08 has shown that 4 months of androgen deprivation therapy (ADT) before and during external beam radiation therapy (EBRT) reduces the overall and the prostate cancer-specific mortality rates for men with localized prostate cancer (clinical stages T1b, [...]

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GI toxicity, radiation therapy, and androgen deprivation

Posted on June 4, 2011 by Sitemaster

For men undergoing the combination of external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT), for treatment of prostate cancer there is a significant risk for gastrointestinal (GI) toxicity over time.

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A matched, case-control study of EBRT + PBRT vs brachytherapy

Posted on April 28, 2011 by Sitemaster

It would be all too easy to get the idea — from the title and abstract of a recently published study — that proton beam radiation therapy (PBRT) was more effective than permanent seed brachytherapy in the treatment of men with low- and some intermediate-risk prostate cancers. This would be a very inappropriate conclusion.

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EBRT as salvage therapy for refractory or progressive prostate cancer post-HIFU

Posted on April 27, 2011 by Sitemaster

An early release paper in the Canadian Urological Association Journal offers information on a series of patients treated with external beam radiation therapy (EBRT) as salvage therapy after biochemical progression following high-intensity focused ultrasound (HIFU) as their first-line treatment.

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Statin therapy seems to improve outcomes after radiation therapy for high-risk patients

Posted on March 23, 2011 by Sitemaster

According to data just published in the March issue of the International Journal of Radiation Oncology•Biology•Physics, patients diagnosed with high-risk prostate cancer who take statins while receiving radiation therapy have a better prognosis than patients treated with radiotherapy who don’t take statins.

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Neoadjuvant hormone therapy for patients undergoing first-line radiation therapy

Posted on September 21, 2010 by Sitemaster

The Irish Clinical Oncology Research Group trial 97-01 was a randomized clinical trial designed to compare the long-term outcomes of patients treated with either 4 months or 8 months of hormonal therapy given before external beam radiotherapy for localized prostate cancer.

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RP vs. EBRT vs. ADT as first-line therapy for localized prostate cancer

Posted on August 16, 2010 by Sitemaster

Earlier this year we reported on a paper by Zelefsky et al. suggesting lower levels of prostate cancer-specific morbidity and mortality after surgery than after radiation therapy. Now there’s similar data from the CaPSURE registry.

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Does concurrent statin therapy help men who have EBRT for localized disease?

Posted on May 24, 2010 by Sitemaster

We know that statin therapy appears to lower risk for prostate cancer and to increase the overall survival of men diagnosed with prostate cancer. However, what we don’t know (yet) is whether statin therapy during and after specific types of treatment has prostate cancer-specific outcome benefits.

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Prostate cancer patients on statins have better outcomes after radiotherapy

Posted on May 7, 2010 by Sitemaster

There is an increasing range of evidence to suggest that men who are on long-term statin therapy (with drugs like simvastatin, atorvastatin/Lipitor, or rosuvastatin/Crestor) are at lower risk for prostate cancer and do better than average in terms of treatment outcome if they are diagnosed with prostate cancer.

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Chronic fatigue after first-line therapy for localized prostate cancer

Posted on February 9, 2010 by Sitemaster

There are few good data on the occurrence of chronic fatigue after first-line treatment of localized prostate cancer.

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