Is mass prostate cancer screening even ethical in men ≥ 65 years of age?

Now here’s a new perspective on the value of widespread prostate cancer screening from one of the founders of Prostate Cancer Awareness Week — Dr. David Crawford of the University of Colorado Health Science Center in Denver, CO  (who is also the Chairman of the Prostate Conditions Education Council):

Cancer (and prostate cancer) screening in the elderly

The value of regular testing of increasingly elderly men and women for risk of cancer is controversial. However, a new paper in the Archives of Internal Medicine has certainly added to our knowledge of just how widespread such testing may be … at least in the USA.

Age-related diagnosis with M1 disease and age-related prostate cancer-specific mortality rates

According to a media release from the University of Rochester, a new study suggests that “men age 75 and older are diagnosed with late-stage and more aggressive prostate cancer and thus die from the disease more often than younger men.”

Excess deaths among some older men with prostate cancer

A population-based analysis of mortality data for men diagnosed with prostate cancer from three European nations suggests that “a small but important group of older patients” initially present with late stage prostate cancer and die rapidly as a consequence.

The role of radical prostatectomy in older males with high-risk prostate cancer

Data reported earlier this year from the PIVOT study and separately from the long-term Scandinavian study have shown that the surgical treatment of prostate cancer in the patients enrolled in these trials showed no median prostate-cancer specific or overall survival benefit compared to watchful waiting in patients of > 65 years of age.

Whole-gland cryoablation as first-line therapy in prostate cancer patients > 75 years of age

Based on data collected in the Cryo On-Line Database (COLD), Dhar et al. have just published an analysis of data from a total of 860 men, all over 75 years of age, who were treated with whole-gland cryoablation for clinically localized prostate cancer at times dating back to at least 1995.

Frequency of PSA testing and immediacy of prostate cancer treatment among men over 70

Two recent publications have offered evidence that, at 10 and 12 years of follow-up, the potential benefits of surgical treatment for low- and intermediate-risk prostate cancer did not include any impact on overall survival for men of 65 years of age or more at the time of surgery.

The management of high- and intermediate-risk prostate cancer in elderly males

Overall life expectancy of men in the US continues to rise. As a consequence, the way we treated localized prostate cancer in men of ≥ 70 years of age in 1990 will probably not be relevant or appropriate to the way we need to treat such men in 2020 (or perhaps even today).

International recommendations on treatment of “older” men

A Prostate Cancer Task Force of the International Society of Geriatric Oncology (SIOG) has just issued new recommendations on the management of prostate cancer in “older men” (by which the task force means men of more than 70 years of age).

Post-treatment mortality of elderly men with high-risk prostate cancer

New data from a series of > 700 elderly patients with high-risk prostate cancer suggests that aggressive combination therapy for such men is associated with a reduced risk for prostate cancer-specific mortality.

Prostate cancer news reports: March 17, 2010

In this news report we summarize studies dealing with: Outcomes after RP in selected patients between 70 and 81 years of age Management of men with prostate cancer recurrence after first-line EBRT Innovative MRI-guided treatments as second- and third-line forms of management Preclinical data on MAOA inhibition in prostate cancer

Prostate cancer news reports: Saturday, February 20, 2010

In today’s news reports we comment briefly on recent papers that deal with: Radical prostatectomy in men > 75 years of age The impact of anticoagulant therapy on clinical outcomes after radiation therapy The “feasibility” of pre-surgical, docetaxel-based chemotherapy in high-risk patients

Prostate cancer news reports: December 8, 2009

In today’s news reports we comment on articles dealing with: The declining rate of prostate cancer mortality in the USA Managing prostate cancer in the elderly Re-validation of the Partin tables RALP as salvage surgery for radiation-resistant patients

Prostate cancer news reports: Friday, November 13, 2009

In today’s prostate cancer news reports we have noted items on: The Prostate Cancer Risk Calculator and its use in community practice Potential guidelines on prostate cancer management for the elderly The relative risk of single focus as compared to multifocal disease

Managing prostate cancer in “unfit” geriatric patients

Falci et al. have reviewed available data on the diagnosis and treatment of prostate cancer in relatively unhealthy (“unfit”), elderly patients — from a European perspective.

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