Could modulation of SPDEF activity lower risk for metastatic prostate cancer?

According to an article just published in the Journal of Biological Chemistry, the authors have identified a biological molecule known as the SAM pointed domain ETS transcription factor or SPDEF controls the expression of E-cadherin — a protein that is known to be very important to the process of prostate cancer metastasis. … READ MORE …

Understanding new tests for risk of clinically significant prostate cancer (Part II)

An article just published on the Medscape web site addresses data on the potential of GenomeDx Bioscence’s new “Decipher” test which “could” (according to one urologic oncologist) help prevent over-treatment of at least some men with prostate cancer. One might ask whether we can — as yet — decipher the value of the Decipher test. … READ MORE …

DNA methylation and the aggressiveness of prostate cancer

According to a media release from the Mayo Clinic earlier today, “Alterations to the ‘on-off’ switches of genes occur early in the development of prostate cancer and could be used as biomarkers to detect the disease months or even years earlier than current approaches.” … READ MORE …

Manserin as possible marker of prostate cancer progression

“Manserin” is a novel peptide originally derived from a larger secretory protein called secretogranin II. A newly published paper suggests that expression of manserin in human prostate cancer tissues may correlate with risk for clinically significant and progressive forms of prostate cancer. … READ MORE …

UK includes prostate cancer in new “stratified medicine” pilot program

According to a report in the Science section of the Financial Times, “the world’s first nationwide genetic testing programme for cancer patients goes into action in the UK next month, with support from the public, private and charitable ­sectors.” … READ MORE …

5α-Reductase-III and its potential in prevention/treatment of prostate cancer

There are in fact three so-called “isozymes” (slightly different versions) of the human enzyme 5α-steroid reductase. The activity of 5α-reductase-II can be affected by the 5α-reductase inhibitor (5-ARI) finasteride (Proscar); the activity of 5α-reductase-I and -II can be affected by the 5-ARI dutasteride (Avodart), but … READ MORE …

Perhaps all too much FUS about something …

As usual, some of our friends in the media are over-hyping a recent publication about the possible effects of a protein called FUS/TLS in the progression of prostate cancer. … READ MORE …

siRNA, NMD, and tumor antigen expression in cancer

A research team at the University of Miami has come up with an innovative new method that (please note the emphasis) might offer a completely new way to eliminate remaining cancer cells in patients with prostate and other types of cancer after first-line therapy. … READ MORE …

Prostate cancer news reports: Friday, May 22, 2009

Today’s news reports cover items on:

  • Gene expression and prostate cancer progression
  • Risk of complications from in-office prostate biopsy
  • Post-RALP voiding function
  • Urinary toxicities after IMRT-SIB
  • Drugs in development for CRPC … READ MORE …

Prostate cancer news reports: Friday, May 15, 2009

In today’s news reports we discuss:

  • Genetic abnormalities and intermediate risk prostate cancer
  • Ginger tablets to prevent chemotherapy-induced nausea
  • Ixabebilone + mitoxantrone in patients after Taxotere … READ MORE …

The early weekend news report: January 17, 2009

There are just two notable reports in today’s early news:

  • On the potential of PMS2 as a prostate cancer marker
  • On age-related cancer outcomes in Europe … READ MORE …
Follow

Get every new post delivered to your Inbox.

Join 832 other followers