Refining a potential genetic component of prostate cancer risk

A new paper by a multi-center research team has refined the long-held suspicion that some types of aggressive prostate cancer may be the consequence of the accumulation of multiple mutations in the patients’ DNA.

Does RAF gene rearrangement cause an aggressive but treatable subtype of prostate cancer?

According to a media release from the Prostate Cancer Foundation yesterday, research at the University of Michigan Comprehensive Cancer Center suggests that the RAF oncogene that drives fatal forms of melanoma (an aggressive type of skin cancer) may also drive aggressive forms of prostate cancer.

Gene fusion and prostate cancer development

An article in today’s Israel Herald might give you the (incorrect) idea that androgen deprivation therapy is completely inappropriate as a  form of treatment for prostate cancer.

Is the TMPRSS2-ERG marker for prostate cancer clinically relevant?

We have long cautioned about whether the presence of apparent biologic “markers” in men with prostate cancer (“association”) is necessarily an implication that a specific marker really indicates anything clinically important. A paper published by a European team now helps to put this in perspective.

Prostate cancer news reports: Friday, June 19, 2009

In today’s news reports we include items on: ETS gene fusions and their future in the diagnosis and management of prostate cancer Outcomes after different types of radiotherapy Micro-RNAs and late stage prostate cancer

Prostate cancer news update: Tuesday, August 19

Recent publications reported on today include: Demonstration of the validity of the Epstein criteria in defining pathologically insignificant prostate cancer A review of the value of sildenafil (Viagra) and similar products in treatment of erectile dysfunction among prostate cancer patients A review of the significance of “gene fusion” and its relevance in prostate cancer

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