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A new paper in the Proceedings of the National Academy of Sciences suggests the existence of a subset of “hypermutated” cell lines in some forms of aggressive prostate cancer.
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, genetics, hypermutation, mutation, variants | Leave a Comment »
According to a report in the Science section of the Financial Times, “the world’s first nationwide genetic testing programme for cancer patients goes into action in the UK next month, with support from the public, private and charitable sectors.”
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: Diagnosis, expression, gene, genetics, Management, risk | Leave a Comment »
We know from a number of older, epidemiologic studies that there seems to be an inverse association between diabetes status and prostate cancer risk. In other words, people with diabetes seem to be less likely to be diagnosed with prostate cancer.
Filed under: Diagnosis, Prevention, Risk | Tagged: allele, diabetes, genetics, genome, risk | Leave a Comment »
A detailed, new genetic analysis of known prostate cancer susceptibility loci appears to have been able to refine our understanding of genetic factors affecting the risk for prostate cancer among African Americans.
Filed under: Diagnosis, Risk | Tagged: African, ancestry, genetics, risk, susceptibility | Leave a Comment »
According to an announcement from the Veterans Administration (VA), it intends to roll out a new program called the Million Veterans Program or MVP which will allow pre-approved research teams to access (de-identified) genetic, military exposure, health, and lifestyle information on U.S. veterans together through one single database.
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: genetics, lifestyle, outcomes, risk | 1 Comment »
Over the past few years we have seen a great deal of discussion of this or that new gene or single nucleotide polymorphism (SNP) or other set of genomic data and the potential of such information to improve the diagnosis or the prognosis of prostate cancer.
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: Diagnosis, genetics, genomics, prognosis, risk, Treatment | Leave a Comment »
For those interested in “brushing up” on their understanding of the risks associated with hereditary and familial forms of prostate cancer, we recommend a brief article in the April issue of the AUA News, which summarizes a “state of the art” lecture to be given by the author at the upcoming annual meeting of the [...]
Filed under: Diagnosis, Management, Prevention, Risk | Tagged: familial, genetics, hereditary, heredity, risk | 1 Comment »
There has been a lot of media “chatter” over the past 3 days about an article published in the journal Cancer Research. The article suggests that an investigational genetic test can project the presence of prostate cancer in biopsy-based specimens with an average accuracy of 97 percent.
Filed under: Diagnosis, Risk | Tagged: Diagnosis, gene, genetics, profiling, risk | Leave a Comment »
Previous research using so-called “genome-wide association studies” or GWAS have suggested that there may be as many as 30 different inherited prostate cancer genetic risk variants. What we don’t know much about yet is the relationships between specific genetic risk variants and the clinical outcomes of patients carrying those variants.
Filed under: Diagnosis, Management, Risk | Tagged: genetics, outcome, risk, SNP, variant | 5 Comments »
There was a report on the AP news service yesterday which suggested that, “Scientists have taken a first step toward improving those problematic PSA tests for prostate cancer, by mixing in some genetic information that might help tell which men really need a biopsy.”
Filed under: Diagnosis, Risk | Tagged: genetics, profiling, PSA, risk | Leave a Comment »
Writing in the July issue of Genomic Medicine, Fredrik Wiklund (an expert on the genetics of prostate cancer) states that, “[R]ecent genome-wide association studies have revealed numerous genetic variants” associated with prostate cancer. He continues by stating,
Filed under: Diagnosis, Management, Prevention | Tagged: gene, genetics, risk | 4 Comments »
A large study of genetic markers in Japanese prostate cancer patients has clearly shown that some of the markers of prostate cancer in Caucasians do not appear in Japanese patients whereas new markers appear to be common among Japanese.
Filed under: Diagnosis, Risk | Tagged: association, genetics, genome, SNP | Leave a Comment »
Over the past few months, the US Food and Drug Administration (FDA) has issued a slew of letters to companies marketing tests designed to provide consumers with information about their genetic profile and their risks for certain types of disease.
Filed under: Diagnosis, Risk | Tagged: genes, genetics, risk, test | 4 Comments »
There’s an article in today’s Wall Street Journal that begins, “Scientists may soon be able to answer the agonizing question facing men with prostate cancer.” The agonizing question is whether a specific individual actually needs early and aggressive treatment for his cancer or can simply monitor it for risk of progression.
Filed under: Diagnosis, Management, Risk | Tagged: classification, genetics, profiling, progression, risk | 3 Comments »
A new article in Cancer Prevention Research not only suggests the possibility that there is a very real association between selenium levels in serum after all, but it also helps to explain why this association may not have shown up in the large, double-blind, and randomized SELECT trial.
Filed under: Diagnosis, Living with Prostate Cancer, Risk | Tagged: genetics, risk, selenium | 1 Comment »
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