First directly comparative data question safety of PBRT vs. IMRT

For the first time, some 15 years after proton beam radiation therapy (PBRT) was initially popularized as a potential treatment for prostate cancer by the group at Loma Linda, we have an independent assessment of the risk for side effects associated with this form of radiation therapy … and the comparative data are not good.

Self-referral and the role of IMRT in treatment of prostate cancer

The issue of whether some urology practices are investing in equipment capable of delivering intensity-modulated radiation therapy (IMRT) with financial motives is back on the front burner again.

Magnesium oxide and prostate movement during radiation therapy

It has previously been proposed by some researchers that daily dosing with magnesium oxide (MgO) — alone or as part of an antiflatulent dietary regimen — can be used to reduce prostate motion (in combination with fiducial markers) during external beam radiation therapy for localized prostate cancer.

Acute and mid-term side effects of high-dose, image-guided IMRT in first-line treatment of localized prostate cancer

Two recent papers have reported data relevant to the application of high-dose, image-guided, intensity-modulated forms of radiation therapy (IGRT/IMRT) in the first-line treatment of men with localized prostate cancer.

How much hypofractionated IMRT is too much for localized prostate cancer?

A report to be presented at the upcoming meeting of the American Society for Radiation Oncology (ASTRO) offers 5-year outcome data from a trial comparing conventional intensity-modulated radiation therapy (IMRT) to the more recently developed hypofractionated IMRT for men with localized prostate cancer.

All the different types of external beam radiation therapy for prostate cancer: a good introduction

Over the past 20 years there has been an explosion in the different ways that we use varied types of external beam radiation therapy for the treatment of localized and locally advanced forms of prostate cancer. Where is the newly diagnosed patient able to find a good, basic introduction?

Toxic side effects of adjuvant, salvage IMRT post-surgery

Prostate cancer patients are commonly concerned about the potential risks for side effects associated with adjuvant and salvage radiation therapy after a preceding, first-line, radical prostatectomy.

GI toxicity, radiation therapy, and androgen deprivation

For men undergoing the combination of external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT), for treatment of prostate cancer there is a significant risk for gastrointestinal (GI) toxicity over time.

10-year outcomes after high-dose IMRT for localized prostate cancer

A new report from Memorial Sloan-Kettering Cancer Center has documented patient outcomes at 10 years after high-dose, intensity-modulated radiation therapy (IMRT)  for men initially diagnosed with clinically localized prostate cancer.

Other prostate cancer news: Wednesday, December 8, 2010

Other prostate cancer news out today includes: An article in the Wall Street Journal about the financial motives behind intensity-modulated radiation therapy (IMRT) Approval from the FDA for a Phase III pivotal trial of PROSTVAC-VF

Slightly fewer (severe) complications after IMRT compared to CRT

According to a media release from the University of Pennsylvania Health System, (and another from the American Society of Radiation Oncology [ASTRO]), intensity-modulated radiation therapy (IMRT) is associated with fewer complications than traditional, three-dimensional conformal radiation therapy (3D-CRT) in the treatment of non-metastatic prostate cancer.

Outcomes of HDR brachytherapy + IMRT vs. very high-dose IMRT alone

As far as we are aware there are limited data comparing the outcomes of patients treated with high-dose IMRT to those of patients treated with high-dose-rate (HDR) brachytherapy + IMRT as first-line therapy.

Prostate volume and risk for acute GU side effects after IMRT

There’s a new article in the radiation therapy literature suggesting a direct correlation between prostate volume and risk for severe, acute, genitourinary toxicity when prostate cancer patients with large-volume prostates are treated with intensity-modulated radiation therapy (IMRT).

IMRT alone vs. HDR brachytherapy + IMRT — short-term outcomes are similar

There have been strong suggestions over the years (at least from some physician groups) that the combination of brachytherapy with external beam radiotherapy (EBRT) was associated with superior outcomes compared to the use of EBRT alone in treatment of localized prostate cancer.

Proton beam vs. intensity-modulated RT: out on the battle lines

The relative merits of proton beam radiotherapy (PBRT) and the more commonly available intensity-modulated radiotherapy (IMRT) as forms of external beam radiation for prostate cancer are much debated … with minimal supportive evidence on either side of the debate because no comparative trial has ever been carried out.

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