“Take home” messages about localized prostate cancer from the AUA annual meeting

An article by Crawford and Arangua on page 3 of the June issue of AUA News provides a series of “take home messages” for attendees of the annual meeting of the American Urological Association in Washington, DC, last month.

Additional 5-year follow-up data on SBRT for localized prostate cancer

In February this year we reported initial 4- and 5-year follow-up data from two US-based research teams on the use of stereotactic body radiation therapy (SBRT or CyberKnife radiation) as a treatment for prostate cancer. A new study from a Korean research group appears to confirm the earlier findings.

Diagnosis and management of localized prostate cancer: the Cleveland Clinic approach

A recent article in the Cleveland Clinic Journal of Medicine provides a summary of the way three leading specialists at this institution approach the diagnosis and management of localized prostate cancer today.

New Phase III trial of “gene suicide therapy” in localized prostate cancer

A biopharmaceutical company called Advantagene, Inc. announced last Thursday that it has reached agreement with the U.S. Food and Drug Administration regarding the conduct of a Phase III clinical trial of a vaccine-like treatment called ProstAtak™ — in combination with standard therapy — in the treatment of patients with newly diagnosed prostate cancer.

HIFU as first-line treatment in 137 Japanese patients

Data from a series of Japanese patients continue to help us to understand the risks and benefits of first-line treatment with high-intensity focused ultrasound (HIFU) for men initially diagnosed with localized prostate cancer and followed for up to 7 years.

Dutasteride delays progression of prostate cancer in REDEEM trial

The abstract for the presentation of the resulsts of the REDEEM trial (to be presented on Thursday at the Gentourinary Cancer Symposium in Orlando) was published this evening on the ASCO web site. The data show that dutasteride delayed progression of prostate cancer in a well-defined group of patients compared to placebo therapy.

Surgery, brachytherapy, HRQOL, and the SPIRIT trial

The Surgical Prostatectomy versus Interstitial Radiation Intervention Trial or SPIRIT was a Phase III, partially randomized clinical trial, conducted in the U.S.A. and Canada, and designed to compare radical prostatectomy (RP) and brachytherapy (BT) as first-line treatments for men with localized prostate cancer.

Comparative evaluation of open vs. robot-assisted surgery for localized prostate cancer

A new paper in the Scandinavian Journal of Urology and Nephrology has provided detailed information about the design and conduct of an ongoing, prospective, non-randomized trial comparing open radical retropubic prostatectomy (RRP) to robot-assisted laparoscopic radical prostatectomy (RALP) in treatment of localized prostate cancer.

Consumer Reports on first-line management of prostate cancer

There is an interesting summary of the major, first-line management options for localized prostate cancer in today’s Washington Post. It has been prepared by the Consumer’s Union (publisher of Consumer Reports) as part of their Consumer Reports Insights series.

Active surveillance gets a major endorsement — in Oz

Awareness of brachytherapy as a treatment for localized prostate cancer was revolutionized in the U.S. in 1996 — not by a doctor but by a patient.

Additional data on short-term outcomes of PBRT

A new report from researchers at the University of Florida Proton Therapy Institute offers us some additional information on the short-term outcomes of first-line treatment with image-guided proton beam radiation therapy (PBRT) for localized prostate cancer.

Why men choose specific first-line types of management for localized prostate cancer

The need for patients diagnosed with early stage prostate cancer to be highly involved in the decision as to which form of management they wish to be given is well understood. However, there has been a relative dearth of data on why patients actually make their individual decisions.

Initial study of single-dose HDR brachytherapy for localized prostate cancer

In the past, high-dose-rate (HDR) brachytherapy has been used alone or (more commonly) in combination with external beam radiation therapy (EBRT) for the treatment of localized prostate cancer. However, when used alone, it has been necessary to treat the patient with several sessions of HDR brachytherapy.

Co-morbidity and management of the man with low-risk, localized prostate cancer

At the beginning of November, we commented on a re-analysis of the PLCO data by Crawford et al. — a re-analysis that focused on the impact of co-morbidities on treatment and outcomes over time.

10-year outcomes after high-dose IMRT for localized prostate cancer

A new report from Memorial Sloan-Kettering Cancer Center has documented patient outcomes at 10 years after high-dose, intensity-modulated radiation therapy (IMRT)  for men initially diagnosed with clinically localized prostate cancer.

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