Increasing focus on the appropriate definition (and management) of prostate “cancer”

As many readers will be aware, there has been a recent and increasing focus on whether abnormal pathological findings on biopsy classified as Gleason grade 3 + 3 = 6 should really be classified as “cancer” at all. This also has major implications for its management.

The new NCCN patient guidelines — a great improvement over last time

We have now had the chance to look carefully through the new, patient-specific guidelines on prostate cancer issued by the National Comprehensive Cancer Network (NCCN) just before the Holidays. They are not perfect, but they are certainly a vast improvement over the NCCN’s first attempt.

Risk stratification in diagnosis and management of prostate cancer

A new article by Vickers, Roobol, and Lilja, scheduled for publication in the January 2012 issue of the Annual Review of Medicine is likely to raise some eyebrows in the urology community.

Aging, demography, and the long-term risk for prostate cancer

A new report from the census bureau indicates that there is (as one might have expected) a rapid growth in the number of people in the US who are now living to 90+ years of age. It is also reasonable to expect that this demographic change has implications for the diagnosis and risk for prostate [...]

Is leucine blockade an important new approach to prostate cancer management?

Newly reported research from a team at the Centenary Institute in Sydney, Australia, has suggested a very different way in which it may be possible to significantly delay or manage the progression of prostate cancer.

The personalization of prostate cancer management: a way to go yet!

A new study just published in the Journal of General Internal Medicine makes a strong case for the importance of individualized application of specific treatments to older men diagnosed with prostate cancer — something which you would think ought to be evident to the majority of clinicians, but apparently wasn’t

New decision aid for men with clinically localized prostate cancer

The Agency for Healthcare Research and Quality (AHRQ) has just released a new, free decision aid to assist men diagnosed with clinically localized prostate cancer in the assessment of their management options.

Educating the family doctor about prostate cancer management

The August 15 issue of American Family Physician — supposedly one of the most widely read medical journals in America — carried an article by Mohan and Schellhammer entitled “Treatment options for localized prostate cancer.” Unfortunately the full text of this article is not available on line for the average reader.

UK includes prostate cancer in new “stratified medicine” pilot program

According to a report in the Science section of the Financial Times, “the world’s first nationwide genetic testing programme for cancer patients goes into action in the UK next month, with support from the public, private and charitable ­sectors.”

“PSA and the family physician”

The full text of a recent article having the above title offers a good (if perhaps not perfect), reasonably current overview of issues related to PSA testing for prostate cancer and appeared recently in a supplement to the Canadian Journal of Urology.

“Toward a rational strategy for prostate cancer screening …”

The heading above is the first part of the title of a paper to be presented by Lilja et al. at the upcoming annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. The data from this study needs to be seen in conjunction with data presented just the other day by Vickers.

The coming realities in the management of prostate cancer

There’s an interesting interview with Dr. Anthony Zeitman — the president of the American Society of Radiation Oncology (ASTRO) — in the most recent issue of The ASCO Post — a news magazine distributed to members of ASCO.

Pre-surgical stress management and radical prostatectomy

One’s attitude of mind is well known to affect one’s response to certain types of treatment for many different disorders. At the very simplest level, people with a “glass half full” mentality do have a tendency to recover better from their illnesses than those who see the glass as being “half empty.”

Could SSRIs be used to manage hot flashes in men on ADT?

There are new data showing that the antidepressant escitalopram (Lexapro/Forest) — a selective serotonin re-uptake inhibitor or SSRI — can significantly reduce hot flashes among women undergoing menopause. If that is the case, one wonders whether drugs of this class might have a similar impact on hot flashes in men on androgen deprivation therapy (ADT).

NCCN issues patient guidelines on prostate cancer diagnosis and management

At some point in the past 3 weeks or so, the National Comprehensive Cancer Network (NCCN) Foundation has quietly issued its new NCCN Guidelines for Patients™ on prostate cancer diagnosis and management.

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