Could SSRIs be used to manage hot flashes in men on ADT?

There are new data showing that the antidepressant escitalopram (Lexapro/Forest) — a selective serotonin re-uptake inhibitor or SSRI — can significantly reduce hot flashes among women undergoing menopause. If that is the case, one wonders whether drugs of this class might have a similar impact on hot flashes in men on androgen deprivation therapy (ADT).

NCCN issues patient guidelines on prostate cancer diagnosis and management

At some point in the past 3 weeks or so, the National Comprehensive Cancer Network (NCCN) Foundation has quietly issued its new NCCN Guidelines for Patients™ on prostate cancer diagnosis and management.

Why men choose specific first-line types of management for localized prostate cancer

The need for patients diagnosed with early stage prostate cancer to be highly involved in the decision as to which form of management they wish to be given is well understood. However, there has been a relative dearth of data on why patients actually make their individual decisions.

When is localized prostate cancer clinically insignificant?

Among prostate cancer specialists, there has been a broad acceptance — for some time — of the idea that a localized prostate cancer “index” tumor with a Gleason score of 6 or less and a volume of ≤ 0.5 cm3 could be considered to be clinically insignificant and therefore did not (necessarily) need to be treated.

Co-morbidity and management of the man with low-risk, localized prostate cancer

At the beginning of November, we commented on a re-analysis of the PLCO data by Crawford et al. — a re-analysis that focused on the impact of co-morbidities on treatment and outcomes over time.

No wonder men get confused about prostate cancer

A story about a 35-year-old male, newly diagnosed with prostate cancer, ran on a Houston television station yesterday.

Does revenue affect a urologist’s management recommendations?

A common topic of discussion among some members of the patient and patient advocacy community is whether recommended management of prostate cancer for individual patients is driven by the potential revenue available to physicians and hospitals from differing recommendations.

Psychosocial distress at diagnosis and 12 months later

Every prostate cancer patient (and many patients subsequently found not to have prostate cancer) have been through the psychological and social distress associated with the risk of a diagnosis of prostate cancer. It’s no fun.

The prostate cancer screening controversy: an evolving, risk-based perspective

WARNING: This commentary may not be suitable reading for those who are firmly convinced that annual, mass, population-based screening of all men over (say) 40 or 50 years of age is the right way to manage prostate cancer risk.

“Is there an optimal management for localized prostate cancer?”

Most knowledgeable prostate cancer advocates and educators know that the answer to this question is “No.” The correct answer is that the management of localized prostate cancer needs to take account of the characteristics, objectives, and expectations of each individual patient, including his overall health and quality of life.

The value of second-line treatment for men with biochemical recurrence

Biochemical failure (also known as biochemical recurrence) after first-line treatment for prostate cancer is assessed based on a rising PSA level. This is a relatively common event and can happen shortly after first line treatment or many years later. The problem is that we really don’t know how important biochemical recurrence is in an individual [...]

AUA annual meeting opens in San Francisco

It is probably fair to say that readers should expect little in the way of revolutionary new information affecting the management of prostate cancer from this year’s annual meeting of the American Urological Association (AUA). However,

How preconceptions impact prostate cancer management

As Leah wrote in a comment on this blog just the other day, “Yes, the ‘D-word’ is still taboo. Death is UNAMERICAN.” The comment stimulated the thought that our preconceptions have significant impact on how we think about risk, diagnosis, and treatment of prostate cancer — and yet there is really very little good research on [...]

Tracking the costs of prostate cancer diagnosis and management

Two recent studies have examined the increasing economic burden of prostate cancer — in the USA and in selected European nations. The picture is not a pretty one.

Managing the side effects of long-term hormone therapy

Three recent publications are focused on the importance of the management of complications of long-term androgen deprivation therapy (ADT) in men with progressive or more advanced forms of prostate cancer.

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