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A new study has confirmed an initial finding that the rare G84E mutation (also known as rs138213197) in the HOXB13 gene is a significant driver of risk for prostate cancer among men with a family history of the disease. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: familial, hereditary, mutation, risk | 1 Comment »
A Letter to the Editor just published in the journal Nature Genetics has suggested that that so-called SPOP mutations may be responsible for between 6 and 15 percent of the prostate cancers diagnosed in the USA each year. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: gene, mutation, SPOP, subtype, targeted | Leave a Comment »
A new paper in the Proceedings of the National Academy of Sciences suggests the existence of a subset of “hypermutated” cell lines in some forms of aggressive prostate cancer. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, genetics, hypermutation, mutation, variants | Leave a Comment »
According to a new paper in the journal Cell, researchers at the Sanger Institute at Cambridge, in England, believe they have discovered a completely new mechanism for the initial development of about 2 or 3 percent of all cancers. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: cause, chromosome, chromothripsis, DNA, mutation | Leave a Comment »
Today’s news reports deal with such matters as:
Filed under: Drugs in development, Management, Treatment, Uncategorized | Tagged: abiraterone, androgen resistance, AT-101, CTC, ERG, mutation, radical prostatectomy | Leave a Comment »
According to another Reuters report, men who develop prostate cancer and who carry one of three possible hereditary mutations to the so-called breast cancer genes BRCA1 and BRCA2 appear to be at particularly high risk for an aggressive form of the disease. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: aggressive disease, BRCA1, BRCA2, mutation, risk | Leave a Comment »
In a fascinating study by scientists from The Institute of Advanced Studies at Princeton and the University of California, Yeang et al. are reporting that a molecular, Darwinian, “survival of the fittest” scenario appears to play out as gene mutations seek to survive through cancerous tumors. … READ MORE …
Filed under: Drugs in development | Tagged: cancer, Darwin, evolution, fittest, mutation, news, prostate, survival, update | Leave a Comment »
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