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A new paper in the Proceedings of the National Academy of Sciences suggests the existence of a subset of “hypermutated” cell lines in some forms of aggressive prostate cancer.
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, genetics, hypermutation, mutation, variants | Leave a Comment »
According to a new paper in the journal Cell, researchers at the Sanger Institute at Cambridge, in England, believe they have discovered a completely new mechanism for the initial development of about 2 or 3 percent of all cancers.
Filed under: Diagnosis, Risk | Tagged: cause, chromosome, chromothripsis, DNA, mutation | Leave a Comment »
Today’s news reports deal with such matters as: Advances in radical prostatectomy Variations in mutation in androgen-resistant patients Data from a Phase I/II trial of AT-101 The link between CTC level and response to therapy with abiraterone
Filed under: Drugs in development, Management, Treatment, Uncategorized | Tagged: abiraterone, androgen resistance, AT-101, CTC, ERG, mutation, radical prostatectomy | Leave a Comment »
According to another Reuters report, men who develop prostate cancer and who carry one of three possible hereditary mutations to the so-called breast cancer genes BRCA1 and BRCA2 appear to be at particularly high risk for an aggressive form of the disease.
Filed under: Diagnosis, Management, Risk | Tagged: aggressive disease, BRCA1, BRCA2, mutation, risk | Leave a Comment »
In a fascinating study by scientists from The Institute of Advanced Studies at Princeton and the University of California, Yeang et al. are reporting that a molecular, Darwinian, “survival of the fittest” scenario appears to play out as gene mutations seek to survive through cancerous tumors.
Filed under: Drugs in development | Tagged: cancer, Darwin, evolution, fittest, mutation, news, prostate, survival, update | Leave a Comment »
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