Early data on targeted focal therapy in treatment of localized prostate cancer

The potential role of targeted focal therapy in the management of localized prostate cancer is yet to be well-defined, so a paper just published on line in the Journal of Urology is of value in helping us to set our expectations. … READ MORE …

Outcomes after first-line and repeat HIFU procedures in the UK

In the UK, the team led by Drs Ahmed and Emberton has been meticulous in its collection and reporting of outcome data related to their investigational use of high-intensity focused ultrasound (HIFU) in the treatment of localized prostate cancer. … READ MORE …

Modern 5-year outcome data after radiotherapy for very high-risk patients

A newly published paper reports 5-year outcome data from a series of men initially diagnosed with very high-risk, but localized prostate cancer — all of whom were treated with either dose-escalated external beam radiation therapy (EBRT) or pelvic radiation + permanent interstitial seed implantation (combined modality radiotherapy or CMRT). … READ MORE …

The SPCG-4 trial: follow-up data after > 23 years

This week’s New England Journal of Medicine contains data from a fifth update to the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) trial of radical prostatectomy vs. watchful waiting in “early” prostate cancer. … READ MORE …

The surgical learning curve and post-RALP outcomes over time

Two new and quite separate papers offer rather different perspectives on the value of robot-assisted laparoscopic prostatectomy (RALP) as a first-line treatment for the management of localized prostate cancer. … READ MORE …

10-year survival data from the RT01 trial of differing doses of 3D-CRT

According to a paper just published in Lancet Oncology today, the 10-year follow-up results of the RT01 trial carried out under the auspices of the British Medical Research Council have shown an overall survival of 71 percent in both arms of this trial of two types of external beam radiation therapy. … READ MORE …

Supervised exercise and prevention of ADT-related side effects

A small, randomized trial in a group of 60+ Australian patients has demonstrated that a supervised exercise program started at the same time as initiation of androgen deprivation therapy (ADT) can have multiple beneficial results, including (at least temporary) avoidance of known side effects of ADT. … READ MORE …

Does “changing urologists” improve outcomes after surgery?

In what appears to be a fascinating study from a group of researchers at the Bloomberg School of Public Health at Johns Hopkins University in Baltimore come data suggesting that patients who “changed urologists” had better short-term surgical outcomes after radical prostatectomy. So the question has to be, what did the research team mean by “changed urologists”? … READ MORE …

5-year follow-up data after proton beam therapy

A new article in the International Journal of Radiation Oncology (the “Red” Journal) provides us with recent 5-year outcomes for men diagnosed with localized prostate cancer and treated with proton beam radiation therapy (PBRT). … READ MORE …

Results of Phase III trial of custirsen (OGX-011) in mCRPC coming soon

According to a media release issued early this morning by OncoGenex Pharmaceuticals, the Phase III SYNERGY trial of custirsen (originally known as OGX-011) has reached its pre-specified endpoint in terms of the number of events required for final analysis of the trial data. … READ MORE …

Predicting outcomes after early salvage radiation therapy for locally recurrent disease

A international, collaborative research group has but together a new nomogram designed to project outcomes at 5 years after early salvage radiation therapy (eSRT) for men with local disease recurrence after first-line surgery for localized prostate cancer. … READ MORE …

Does regional analgesia reduce risk for cancer progression when added to general anesthesia?

Based on a retrospective analysis of data from > 1,600 patients treated by radical prostatectomy at the Mayo Clinic, a newly published paper suggests that supplementing general anesthesia with regional (neuraxial) analgesia may lower risk for disease recurrence. … READ MORE …

Long-term outcomes of higher- vs. lower-dose radiation therapy

There is still no absolute clarity to the degree of benefit associated with higher-dose as opposed to older, lower-dose external beam radiation therapy for men with localized prostate cancer. … READ MORE …

Prostate Cancer Roundtable updates national policy agenda

The Prostate Cancer Roundtable has just announced an update to its national policy agenda — to include a focus on the importance of patient-reported outcomes data affecting quality of life in trials designed with survival as the primary endpoint. … READ MORE …

Relationship between patient satisfaction and physician-specific outcomes data

A new paper in the Journal of Urology has confirmed that there is a strong correlation between patient satisfaction post-treatment and the ability of physicians to provide counsel to patients about clinical outcomes after treatment based on their own, personal experience and outcomes data. … READ MORE …

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