Robot-assisted versus open radical cystectomy: no clear signs of immediate benefit

Many readers of this blog have probably heard or read the reports like this one on the CBS Evening News or this one on the Reuters web site that there were no significant short-term (perioperative) differences in outcome between robot-assisted radical cystectomy (complete removal of the bladder) and the older open surgical procedure. … READ MORE …

If you’re already depressed, you may need help to make good decisions

In a rather less that surprising finding, a new paper in the Journal of Clinical Oncology reports that men with existing depressive disorders at the time of diagnosis with prostate cancer “are less likely to undergo definitive treatment and experience worse overall survival.” … READ MORE …

Time to prove a treatment-related prostate cancer survival benefit

For most of the past 20 years it has generally been considered that it took 10 years to show that a new form of therapy was effective and safe in the treatment of localized prostate cancer. We may need to seriously re-assess that time period. … READ MORE …

Formal update on Sunnybrook active surveillance data at AUA annual meeting

Over the weekend, Klotz et al. provided interesting new information in the third and most recent, formal update of the prospective data from the active surveillance series being monitored at Sunnybrook Cancer Center in Toronto, Canada. … READ MORE …

Efficacy of continuous ADT and correlation to nadir serum T levels

We had “missed” a poster presented at the recent meeting of the European Urology Association that appears to “put to bed” — in a positive fashion — the question of a relationship between nadir serum testosterone (T) levels in men on continuous androgen deprivation therapy (ADT) and the long-term effectiveness of continuous ADT. … READ MORE …

Heterogeneity of outcomes after radical prostatectomy: the surgeon is a factor

It will come as no surprise to regular readers of this blog that there is variation among surgeons in the overall quality of their patients’ outcomes after radical prostatectomy. However, a newly published and large study of outcomes among surgeons in Sweden does expand our knowledge on this topic. … READ MORE …

Small problem in evaluation of NX-1207 in early stage, low-risk prostate cancer

Now here’s an  embarrassing admission for a drug development company to have to make … READ MORE …

Could adding an aspirin extend prostate cancer-specific survival?

There is an interesting new paper in Cancer Biology and Therapy again suggesting the possibility that men diagnosed with high-risk prostate cancer who are taking anticoagulant therapy do better than similar men who are not on anticoagulants. … READ MORE …

Early data on targeted focal therapy in treatment of localized prostate cancer

The potential role of targeted focal therapy in the management of localized prostate cancer is yet to be well-defined, so a paper just published on line in the Journal of Urology is of value in helping us to set our expectations. … READ MORE …

Outcomes after first-line and repeat HIFU procedures in the UK

In the UK, the team led by Drs Ahmed and Emberton has been meticulous in its collection and reporting of outcome data related to their investigational use of high-intensity focused ultrasound (HIFU) in the treatment of localized prostate cancer. … READ MORE …

Modern 5-year outcome data after radiotherapy for very high-risk patients

A newly published paper reports 5-year outcome data from a series of men initially diagnosed with very high-risk, but localized prostate cancer — all of whom were treated with either dose-escalated external beam radiation therapy (EBRT) or pelvic radiation + permanent interstitial seed implantation (combined modality radiotherapy or CMRT). … READ MORE …

The SPCG-4 trial: follow-up data after > 23 years

This week’s New England Journal of Medicine contains data from a fifth update to the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) trial of radical prostatectomy vs. watchful waiting in “early” prostate cancer. … READ MORE …

The surgical learning curve and post-RALP outcomes over time

Two new and quite separate papers offer rather different perspectives on the value of robot-assisted laparoscopic prostatectomy (RALP) as a first-line treatment for the management of localized prostate cancer. … READ MORE …

10-year survival data from the RT01 trial of differing doses of 3D-CRT

According to a paper just published in Lancet Oncology today, the 10-year follow-up results of the RT01 trial carried out under the auspices of the British Medical Research Council have shown an overall survival of 71 percent in both arms of this trial of two types of external beam radiation therapy. … READ MORE …

Supervised exercise and prevention of ADT-related side effects

A small, randomized trial in a group of 60+ Australian patients has demonstrated that a supervised exercise program started at the same time as initiation of androgen deprivation therapy (ADT) can have multiple beneficial results, including (at least temporary) avoidance of known side effects of ADT. … READ MORE …

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