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One of the hardest things to be able to do, currently, in a man with progressive prostate cancer after first- or second-line therapy, is to determine his risk for lymph node-positive prostate cancer or LNPPC (i.e., one of the earliest and more common components of metastatic prostate cancer). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: accuracy, identification, imaging, lymph node, positive, test | 5 Comments »
In recent years it has become increasingly widely accepted that clinical stage is of dubious value as a prognostic factor in determining prostate cancer risk, particularly as regards the sub-stages of clinical stage T2 (i.e., T2a, T2b, and T2c) in men with localized prostate cancer. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: biopsy, cores, localized, positive, PPC, staging | 10 Comments »
A new study just published in BJU International offers data suggesting the idea that all men found to have positive seminal vesicles (SV+) after radical prostatectomy should receive immediate adjuvant treatment with external beam radiation and androgen deprivation therapy (ADT). … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: adjuvant, ADT, androgen deprivation, positive, radiation therapy, seminal vesicle | 36 Comments »
There are no absolute guidelines as to which patients who have positive surgical margins after a radical prostatectomy (RP) are most appropriate for immediate adjuvant radiation therapy (with or without neoadjuvant and/or adjuvant hormone therapy). … READ MORE …
Filed under: Management, Treatment | Tagged: adjuvant, margin, outcome, positive, radiation, radical prostatectomy | 3 Comments »
So lots of posters and and presentations this morning, but not a lot of actionable information for patients (as far a we could tell). Among the more interesting papers were the following: … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: Gleason score, MDV3100, mortality, OGX-011, positive, risk, surgical. margin | Leave a Comment »
An interesting research question is whether, given the earlier diagnosis, the reduced risk for positive surgical margins, and the reduced likelihood of positive lymph nodes at the time of diagnosis in the contemporary PSA era, there has been any impact on the long-term outcomes of men with pathologic T3b prostate cancer post-surgery. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: outcome, positive, pT3b, seminal vesicle, surgery | 6 Comments »
A new study has clearly shown that men with lighter (and therefore smaller) prostates are at greater risk for positive surgical margins after robot-assisted laparoscopic prostatectomy (RALP) than men with heavier (and therefore larger) prostates. … READ MORE …
Filed under: Management, Treatment | Tagged: margin, positive, PSM, risk, volume, weight | Leave a Comment »
A new study has suggested that, although the PCA3 test is slightly better than the total PSA test in prediction of risk for a positive biopsy finding, it is not necessarily always better than the free PSA test. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: biopsy, free, PCA3, positive, PSA, risk, total | 1 Comment »
The current report offers a revised and updated commentary on the paper by Abd et al., first referred to yesterday on this blog. We have now had the opportunity to read the entire paper. While it does not change the general tenor of our prior comments, it is useful to make sure one has all relevant information on a topic this important. … READ MORE …
Filed under: Diagnosis | Tagged: biopsy, cores, Diagnosis, number, positive, veteran | Leave a Comment »
An analysis of data from the Rotterdam and Göteborg subsets of men enrolled in the European Randomized Screening for Prostate Cancer (ERSPC) study suggests that PSA velocity is of little value in the identification of men who would benefit from a second biopsy after a first, negative biopsy. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: biopsy, positive, probability, PSA, velocity | Leave a Comment »
It is educational to compare the data from the Mayo Clinic, published just the other day, with data just reported by the University of Michigan, which show a clear association between the presence of positive surgical margins and disease-free patient survival in prostate cancer patients. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: positive, prognosis, radical prostatectomy, surgical. margin | Leave a Comment »
For many years, the urology group at the Mayo Clinic has argued that surgery is a viable form of treatment for at least some patients with TxN+M0 prostate cancer. A retrospective analysis of data from the Munich Cancer Registry in Germany now seems to confirm this argument. … READ MORE …
Filed under: Management, Treatment | Tagged: lymph nodes, positive, radical prostatectomy, RP, survival | Leave a Comment »
Maybe 20-30 percent of all prostate cancer patients will be told, today, after a radical prostatectomy, that they a have a positive surgical margin. But exactly what impact a positive surgical margin has on a patient’s risk for disease recurrence has never been very clear. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: positive, prognosis, radical prostatectomy, surgical. margin | 11 Comments »
This month’s issue of AUA News carries two articles espousing different opinions about the appropriate use and timing of radiation therapy for prostate cancer patients who have positive surgical margins after an initial radical prostatectomy. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment, Uncategorized | Tagged: adjuvant, positive, radiation, surgical. margin | Leave a Comment »
A study just published by Sæther et al. appears to suggest that the clinical finding of a positive surgical margin (PSM) is not an important independent predictor for risk of progression when compared to other data available at the time of surgery. … READ MORE …
Filed under: Management, Treatment | Tagged: cancer, margin, news, positive, prognosis, prostate, PSM, surgical | Leave a Comment »
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