What should one do if one’s PSA remains detectable after radical prostatectomy?

After surgery, PSA should become “undetectable” on a normal PSA test (i.e., < 0.1 ng/ml) within a month or two, but sometimes it remains elevated. The primary purpose of the ARO 96-02 randomized clinical trial was to determine whether there was an advantage to treating stage T3-4N0 patients while PSA was still undetectable, or whether they could wait to be treated. … READ MORE …

PSA levels and eligibility for active surveillance

The general rule has been that only men with low-risk prostate cancer are suitable as possible candidates for active surveillance. Low risk is defined as a PSA < 10 ng/ml; a Gleason score of ≤ 6; and a clinical stage of ≤ T2aN0M0. … READ MORE …

To screen or not to screen: an Australian “discrete choice experiment”

The question of whether men should be regularly screened for risk of prostate cancer through the use of the PSA test is (at least) controversial … READ MORE …

Prostvac-type vaccine therapy in progressive prostate cancer after first-line therapy

A study just published in European Urology has suggested that early therapy with Prostvac-type vaccines might have value in the management of men with a rising PSA after first-line therapy. … READ MORE …

PSA doubling time, seminal vesicle invasion, and efficacy of salvage radiation therapy

A small study from one hospital in Norway has suggested that PSA doubling times after surgery may predict the value of salvage radiation therapy alone as a second line form of therapy. … READ MORE …

MRI/TRUS fusion biopsies in men with PSA values < 5.2 ng/ml

There is a distinctly “odd” paper in the December 2014 issue of the Journal of Urology on optimization of the use of MRI/TRUS fusion-guided biopsies in men suspected of having prostate cancer. … READ MORE …

The Prostate Health Cocktail in management of biochemically recurrent prostate cancer

A newly published paper by some highly regarded researchers provides data from a small, Phase II trial of Prostate Health Cocktail (PHC) — an “over-the-counter” combination herbal supplement — in the management of biochemical recurrence of prostate cancer. … READ MORE …

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