First-line enzalutamide in high-risk, ADT-naive patients (including those with metastatic disease)

According to data to be presented at the upcoming meeting of the American Society of Clinical Oncology (ASCO), enzalutamide monotherapy substantially reduces PSA levels in androgen deprivation therapy (ADT)-naive patients with progressive or high-risk disease (including men with evident metastases). … READ MORE …

Further comment from the AUA on new PSA screening guidance

The American Urological Association (AUA) sent the following additional message to its members with the past 90 minutes: … READ MORE …

Follow-up on the new AUA guidelines on screening for risk of prostate cancer

One of the things that is most interesting about the new guidelines issued by the AUA last week (see here for original announcement) is that they seem to be gaining reasonably widespread approval — probably because they are actually (and finally) based on actual evidence as opposed to raw opinion. … READ MORE …

AUA issues new guidance on screening for prostate cancer

As of 7 am this morning, the American Urological Association (AUA) has issued a new set of guidelines on screening for prostate cancer. The full text of this set of guidelines is already available on the AUA web site. … READ MORE …

“HG-PIN alone should not be an indication for further biopsies” in the PSA era

A podium presentation by Kingman et al. at the upcoming annual meeting of the American Urological Association (AUA) may be among the most significant to be presented at the meeting. It seriously challenges the long-held belief about the need to routinely re-biopsy men initially diagnosed with high-grade prostatic intraepithelial neoplasia (HG-PIN). … READ MORE …

Finnish Prostate Cancer Screening Trial shows very limited impact on mortality after 12 years

According to a recent analysis of data from the Finnish Prostate Cancer Screening Trial (which was the single largest contributor to the data collected in the European Randomized Study of Screening for Prostate Cancer or ERSPC), this Finnish trial showed no statistically significant reduction in mortality at 12 years of follow-up. … READ MORE …

Screening smarter — more supportive PSA data from the Malmö Preventive Project

So a new paper just published in the British Medical Journal offers further evidence that a PSA test offered to men between 45 and 49 years of age can predict lifetime risk for prostate cancer with a significant level of accuracy. … READ MORE …

ACP issues new guidance about PSA testing to primary care physicians

The Clinical Guidelines Committee of the American College of Physicians (ACP) — one of the most influential primary care medical societies in the USA — has just issued a new set of guidelines on screening for prostate cancer. Many prostate cancer patients are likely to be deeply disturbed by these guidelines. … READ MORE …

“Screen smarter” and treat less is the message

The March 2013 issue of the AUA News carries a strong message from two leading experts on the early diagnosis and treatment of localized prostate cancer regarding the appropriate use of PSA testing for risk of prostate cancer and consequent follow-up. … READ MORE …

A very different way to project risk for clinically significant prostate cancer?

We don’t want to suggest that the recent paper by a Japanese research team in the journal Andrology is necessarily going to revolutionize the diagnosis of clinically significant prostate cancer. A great deal more work would be required to justify the hypothesis that they put forward. On the other hand, their hypothesis is definitely interesting. … READ MORE …

Is possible new prostate cancer vaccine really “promising”?

A new article on the Medscape Oncology web site (and again correlated with a media release sent out by the European Association for Urology [EAU] from their annual meeting in Milan, Italy) is headed “Prostate cancer vaccine shows promise.” However, the degree of that “promise” appears to be open to some question. … READ MORE …

For our “natural therapy” adherents from the GU Cancers Symposium

There were two posters presented at the Genitourinary Cancers Symposium regarding the use of “natural” agents in the management of prostate cancer. … READ MORE …

More good info in the GU Cancers Symposium “Daily News”

The print and online “Daily News” provided by the organizers of the Genitourinary Cancers Symposium here in Orlando offers additional articles today that may be of interest to many InfoLink readers. … READ MORE …

Who really “discovered” the PSA test?

In the past few years Dr. Richard Ablin has published a number of articles and commentaries claiming that he “discovered” the PSA test. His claim has been controversial ever since he first made it, and a Letter to the Editor of The ASCO Post, published in the December 15, 2012, issue of the magazine, presented a very different point of view. … READ MORE …

New point of care PSA test … coming soon to your doctor’s office?

According to a media release issued last week by a relatively new company called True Diagnostics, Inc., they hope shortly to be able to introduce a new, “point of care” technical system that can be used to assay PSA levels from a “finger-prick” quantity of blood, thus allowing almost instant assessment of PSA levels in the doctor’s office. … READ MORE …

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