Does smoking history predict PSA levels in a clinically significant manner?

A new paper published on line in the Journal of Urology suggests that the PSA and %free PSA levels of current smokers and former smokers may be statistically significantly impacted compared to those of men who have very rarely or never smoked.

AHRQ responds to letter from Prostate Cancer Roundtable

Members of the Prostate Cancer Roundtable have received a letter from the Agency for Healthcare Research and Quality (AHRQ) addressing issues raised by the Roundtable members about the draft USPSTF recommendations on use of the PSA test in screening for risk of prostate cancer.

Sebelius has NOT overruled USPSTF recommendation after all

For our US-based readers … It appears that Rep. Kucinich’s statements on his web site (reported on this web site a few days ago) are something of a political simplification of reality.

Has Sebelius overruled USPSTF recommendation on PSA screening?

According to an announcement on the web site of Congressmen Dennis Kucinich late yesterday, HHS Secretary Kathleen Sebelius has agreed to overule the draft recommendation issued by the U.S. Preventive Services Task Force (USPSTF) related to the use of PSA testing as a means to detect prostate cancer.

The scientific basis for PSA monitoring after first-line treatment for localized prostate cancer

A new article in the Canadian Medical Association Journal has reported on a careful analysis of the published literature underlying current guidelines on the use of repetitive PSA testing to monitor risk for progression in men receiving first-line treatment for localized prostate cancer.

Long-term, PSA-based risk for prostate cancer

In September last year we provided information about a Danish study by Orsted et al. on the use of PSA levels in projecting the long-term risk of prostate cancer that had been presented at a scientific meeting in Europe.

Prostate cancer risk: an investigative journalist’s tale

When Paul VanDervelder was told his PSA had spiked, he did what many men do. He panicked! But then he did what he was trained to do as an investigative journalist. He investigated.

Who needs aggressive treatment after initial radiation … and who does not?

A new report in Lancet Oncology offers guidance on which patients with prostate cancer who are initially treated with radiotherapy and 6 months of neoadjuvant androgen deprivation therapy (ADT) are at relatively high and relatively low levels of risk for prostate cancer-specific mortality.

A multi-specialty review of current evidence regarding prostate cancer screening

The October issue of the Canadian Journal of Urology contains an interesting and thorough review of the available data on the value of screening for prostate cancer as seen by a group including urologists, urologic oncologists, medical oncologists, radiation oncologists, and a highly regarded primary care physician.

Prostate cancer screening (in Germany): curative or harmful?

The debate over the merits and risks of widespread screening for prostate cancer using the PSA test is hardly confined to the USA. A new article (in German) in the journal Urologie A addresses exactly the same issues as have recently received so much attention here in the States.

Beware over-reaction to ultrasensitive PSA doubling times

It is not exactly “new” news that PSA doubling times calculated using low levels of ultrasensitive PSA data can be very different to those calulated using standard PSA values. However, a new paper has provided some additional data on this issue.

AUA issues full, formal comments on USPSTF draft recommendation

On November 8, the American Urological Asociation (AUA) issued its full, formal comment letter on the US Preventive Services Task Force (USPSTF)’s draft recommendation of a “D” grade for the use of PSA screening in healthy men with no symptoms of prostate cancer. The AUA also issued a formal statement for the media.

Are changes in PSA kinetics potentially indicative of metastasis-free survival?

Researchers at Johns Hopkins have provided data to support the hypothesis that, in men being treated with novel, non-hormonal agents for non-metastatic, non-castrate, biochemically recurrent prostate cancer after first-line therapy, changes in PSA kinetics may be indicative of metastasis-free survival.

PSA screening today: four points of view in the NEJM

This week’s issue issue of the New England Journal of Medicine includes four perspective articles on the recent draft recommendation about PSA screening issued by the U.S. Preventive Services Task Force (USPSTF).

What happens next after a baseline PSA test?

According to data from a prospective study of prostate cancer outcomes conducted by researchers at the Mayo Clinic, the PSA test is “valuable in predicting which men should have biopsies and which are likely to be diagnosed with low-risk prostate cancer.”

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