Utilization of standard treatments for localized prostate cancer by Medicare beneficiaries

In a new paper just published on-line in the Journal of Urology, Kapoor et al. have provided data on trends in the utilization of various major types of treatment for the management of localized prostate cancer among Medicare beneficiaries in the USA between 2006 and 2008.

Impact of ADT on all-cause mortality in men treated with brachytherapy-based radiation therapy

The addition of androgen deprivation therapy (ADT) to radiation therapy for men with localized prostate cancer is common. It may be used to reduce the size of the prostate prior to brachytherapy or for longer periods in men with higher risk disease to extend survival (which has been demonstrated in large-scale, randomized, multi-center clinical trials).

Toxic side effects of adjuvant, salvage IMRT post-surgery

Prostate cancer patients are commonly concerned about the potential risks for side effects associated with adjuvant and salvage radiation therapy after a preceding, first-line, radical prostatectomy.

Is radiation therapy any better than active surveillance for localized prostate cancer?

An updated, systematic review just published in Annals of Internal Medicine states that it is impossible to come to any conclusions about the efficacy of radiation therapy compared with active surveillance or watchful  waiting for the management of localized prostate cancer because of the absence of any high-quality, comparative data.

What different specialists believe about adjuvant radiation therapy

A recent study published in “The Red Journal” suggests (perhaps not surprisingly) that radiation oncologists and urologists have different mindsets about the application of immediate adjuvant radiation therapy following surgery for prostate cancer patients with a variety of adverse pathologic risk factors.

The effectiveness of salvage surgery for radiation-recurrent prostate cancer

Knowledge of the effectiveness and safety of radical prostatectomy as salvage treatment for men with biochemical recurrence after first-line radiation therapy has long been hampered by the fact that most data are based on small series of patients from individual institutions.

Post-op pelvic anatomy after RALP and open surgery

According to an article by Hirsch et al. in the inaugural issue of Practical Radiation Oncology (a new journal for radiation oncologists and their staff), there are some small but significant post-operative differences in pelvic anatomy between patients who undergo robot-assisted laparoscopic prostatectomy (RALP) as opposed to standard, open forms of radical prostatectomy.

6 months of neoadjuvant ADT doubles survival when given with radiation therapy

A new article in Lancet Oncology has reported that a mere 6 months of neoadjuvant hormone therapy, when combined with radiation therapy, cuts the risk of dying from locally advanced prostate cancer by 50 percent compared to radiation alone at 10 years of follow-up.

Salvage cryotherapy as second-line treatment after first-line radiation therapy

We really have no idea what the “best” way is to treat men with progressive disease after first-line radiation therapy.

The right way to deliver palliative radiation therapy for pain management

It has come to our attention that the American Society for Radiation Oncology (ASTRO) has developed new guidance on the use of palliative external beam radiation therapy (EBRT) for the management of pain associated with metastasis of cancer to bone — a relatively common problem in late stage, metastatic prostate cancer.

Preliminary results of RTOG 96-01 in progressive prostate cancer

RTOG 96-01 is a randomized, multi-center Phase III trial designed to compare bicalutamide monotherapy + salvage radiation therapy  to a placebo + salvage radiation alone in men with pT2-3N0Mo prostate cancer who have an elevated PSA after surgery.

Other prostate cancer news: Wednesday, December 8, 2010

Other prostate cancer news out today includes: An article in the Wall Street Journal about the financial motives behind intensity-modulated radiation therapy (IMRT) Approval from the FDA for a Phase III pivotal trial of PROSTVAC-VF

The aggressive treatment of high-risk localized and node-positive prostate cancer

Long-term follow-up data have just been published from two studies designed to provide preliminary information on the potential use of very aggressive forms of treatment in men with high-risk categories of prostate cancer.

Risk for secondary cancers after first-line radiation therapy for prostate cancer

There is a recognized risk for development of secondary primary cancers (SPCs) after first-line treatment with radiation therapy for localized prostate cancer. However, a new article suggests that newer forms of radiation therapy may have noticeably reduced that risk.

An interesting report on GU and other complications after PBRT

A new article on the WebMD web site appears under the heading “Targeted radiation may help men avoid impotence,” but it is the incidence of adverse genitourinary (GU) obstructive symptoms during and after treatment that is of greater interest to The “New” Prostate Cancer InfoLink.

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