Is baseline free serum T a factor in appropriate management on active surveillance?

Analysis of data from a cohort of 154 Chilean men with prostate cancer, all being monitored on active surveillance, suggests that free serum testosterone levels (but not total testosterone levels) may be able to help to predict which of these men will go on to need active treatment. … READ MORE …

ART or SRT in high-risk patients post-surgery?

As many of our regular readers will know, there is no clear answer to the question whether, among men at elevated risk of progressive disease after first-line surgery, it is better to have adjuvant radiation therapy (ART) within a few months of surgery or to wait until salvage radiation therapy (SRT) is clearly advisable. … READ MORE …

The absolute increase in risk of prostate cancer after a vasectomy

Late last week we commented briefly on a paper by Siddiqui et al. that had assessed the association between risk for a diagnosis of prostate cancer and the prior occurrence of a vasectomy in men who participated in the Health Professionals Follow-up Study (HPFS). … READ MORE …

5-ARIs and risk for high-grade prostate cancer: yet another data set

The question of whether the use of 5α-reductase inhibitors (5-ARIs) like finasteride (Proscar) and dutasteride (Avodart) is really associated with a significantly increased risk for diagnosis of high-risk and/or lethal prostate cancers remains unanswered. However, yet another set of data from the Health Professionals Follow-up Study (HPFS) has offered us some additional insights. … READ MORE …

Vasectomy and prostate cancer — the debate evolves

As regular readers will be well aware, the question of whether there is a real cause and effect association between having a vasectomy and the later risk for diagnosis of prostate cancer is controversial and unanswered in any absolute sense. However, there are new data that we can now put on the table … … READ MORE …

USPSTF on PSA screening … a current update …

The U.S. Preventive Services Task Force (USPSTF) has just issued its “Guide to Clinical Preventive Services” for 2014. The publication (which is available on line) includes summary information about screening for prostate cancer. … READ MORE …

Maybe this time … a real answer to the value of PSA screening?

We have frequently referred to an ongoing trial in the UK known as the ProtecT trial. That trial is comparing the effectiveness and safety of surgery, radiation therapy, active surveillance as treatments for well-characterized men diagnosed with localized prostate cancer … but there is something else important we hadn’t realized … … READ MORE …

How many miles do you cycle each week?

A recently reported study from the UK — an element of the Cycling for Health UK Study — has suggested the possibility of an association between regular cycling, the intensity of cycling (in hours per week), and risk for a diagnosis of prostate cancer. However, this study does need to be read with great care. … READ MORE …

Risk for 120-day prostate biopsy-specific mortality — redux

Once upon a time (not so very long ago) Boniol et al. suggested that the 120-day mortality rate associated with biopsies for risk of prostate cancer might be as high as 1.3 percent. This caused something of a furore. … READ MORE …

Low insurance, high risk (for prostate cancer mortality among African Americans)

A recently published paper in the journal Urologic Oncology has confirmed that (regrettably but unsurprisingly), here in the USA, African-American men with high-risk prostate cancer are significantly less likely than white males to be given definitive treatment with curative intent. … READ MORE …

Suicide gene therapy for prostate cancer: some VERY early data

Data from a small, distinctly esoteric, Phase II clinical trial of a form of prostate cancer suicide gene therapy along with radiation therapy have suggested that such treatment may be able to stop the development of some early stage forms of prostate cancer (but such data need to be interpreted with great care). … READ MORE …

Parental diagnosis and familial risk for prostate cancer: an 78-year analysis

A new study in the European Journal of Cancer has confirmed the key importance of heredity (i.e., genetic inheritance) as one of the risks for prostate cancer and two other common forms of cancer (breast and colorectal cancers). … READ MORE …

Why would prostate cancer be less likely in HIV-positive men?

A new article has explored further previously reported observations that prostate cancer appears to occur with lower incidence in men already diagnosed as positive for human immunodeficiency virus (HIV) than in their HIV-negative, “normal” peers. … READ MORE …

Prostate cancer in younger men: an important new review

An article in this month’s issue of Nature Reviews: Urology has looked closely at a question of significant relevance to an important subset of our regular readers — Is prostate cancer in some way “different” in younger men? … READ MORE …

Post-biopsy infections in Sweden: a national, 5-year assessment

The increasing incidence of infections associated with transrectal ultrasound (TRUS)-guided prostate biopsy is a topic we have touched on a number of times before. This has been clearly recorded in Canada and the USA and it now appears that the same trend can be well documented in Sweden too. … READ MORE …

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