The relationship between diet and risk for cancer

Many readers of this blog might want to read the article by George Johnson in today’s New York Times. He reports on the evolving hypothesis that any relationship between diet and risk for cancer is becoming less and less likely … which would also explain why changing one’s diet is unlikely to actually prevent cancers too (prostate cancer included).

How to mislead the public: a case study in apparent naivety

An article in today’s Daily Telegraph in the UK starts with the misleading statement that, “Up to half of men diagnosed with prostate cancer are being given ‘false hope’ by tests that are underestimating the severity of their disease, according to the authors of a new study.” … READ MORE …

Circumcision and risk for prostate cancer: an unresolved debate

For more than 70 years there has been an ongoing if sporadic debate about whether circumcision (in infancy or later in life) has any impact on risk for prostate cancer … or not. … READ MORE …

Another potential genomic test for prostate cancer aggression

In a presentation given last Saturday at the annual meeting of the European Society for Radiotherapy and Oncology (ESTRO) in Vienna, a Canadian research team introduced yet another potential test that may be helpful in differentiating between patients at relatively high or low risk for metastasis, based on biopsy tissue. … READ MORE …

Gleason score and metastatic prostate cancer; risk for 4-year mortality

It is difficult to accurately interpret a set of data just published that was designed to assess the relationship between 4-year survival and Gleason score at diagnosis in men initially diagnosed with metastatic prostate cancer. … READ MORE …

OPKO launches 4Kscore Test™ for risk of prostate cancer; data still to come

According to a media release on the OPKO corporate web site, the company is now starting to carry out its previously discussed 4Kscore test for urologists and their patients here in the USA through its CLIA-accredited laboratory in Nashville, Tennessee. … READ MORE …

Just how good is multiparametric, 3-T MRI at finding, staging localized disease?

It is clear that modern magnetic resonance imaging is getting closer to being able to make a major difference to the way that we diagnose (and potentially manage) localized prostate cancer … always assuming we can afford the costs involved (at least here in the USA). … READ MORE …

What to make of a PCA3 score of ≥ 100

Some studies (e.g., this one by Roobol et al.) have previously indicated that not all men with very high prostate cancer antigen 3 (PCA3) scores are necessarily found to have prostate cancer on biopsy or re-biopsy. … READ MORE …

Let’s compare the media hype to the actual data (about MR-guided biopsy)

According to an article online in The Australian today, “Men won’t need to have numerous painful needles in their rectum to find out if they have prostate cancer anymore”. … READ MORE …

New NCCN guidelines on prostate cancer are not an all-around success!

Alas, the latest revisions to the National Comprehensive Cancer Network (NCCN) guidelines on early detection of prostate cancer seem to have instigated more furore than they have clarity (although the original premise behind them may have been well intentioned). … READ MORE …

Statins and risk for diagnosis of prostate cancer … a not so small surprise

A recently published article in Prostate Cancer and Prostatic Diseases has suggested (again) that statin therapy can decrease risk for a diagnosis of prostate cancer … but this new article comes with a special twist in the tail …. … READ MORE …

Is SBRT more toxic than IMRT in treatment of localized prostate cancer?

A new paper, published online today in the Journal of Clinical Oncology, suggests that stereotactic body radiation therapy (SBRT, commonly delivered using the CyberKnife system) has a higher risk for genitourinary (GU) toxicity than intensity-modulated radiation therapy (IMRT). … READ MORE …

PCA3 density as a marker for prostate cancer risk?

Regular readers will be aware that a PSA density (i.e., PSA ÷ prostate volume) > 0.15 has been identified and characterized as a risk factor for clinically significant prostate cancer by researchers at Johns Hopkins. … READ MORE …

BPA levels in urine and risk for prostate cancer — is the association “real”?

A small study published this week in the journal PLoS One this week has provided further evidence of the possibility that significant exposure to the toxic chemical bisphenol A may be associated with heightened risk for a diagnosis of prostate cancer. … READ MORE …

“Five golden rules” for prostate cancer screening and treatment today

In a very simple and straightforward article in European Urology, Vickers et al. have clearly laid out a series of five “golden rules” that, in their opinion, all physicians should be following today when they are testing men for risk of prostate cancer through the use of the PSA test. … READ MORE …

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