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Over the years there has been controversy as to the existence of an association between vasectomy and risk for prostate cancer. A new set of data from a large, long-term study, to be presented at the upcoming annual meeting of the American Society of Clinical Oncology, has shown that there is, indeed, such a risk — but it is specific to high-risk prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Risk | Tagged: Diagnosis, risk, vasectomy | 2 Comments »
According to Reuters, a new article, forthcoming on line in the Annals of Internal Medicine, tells us (not too surprisingly) that, “Older men with other illnesses may not live long enough to benefit from aggressive prostate cancer treatments, such as prostate removal or radiation, and they’d have to live with their side effects.” … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: active surveillance, age, expectancy, life, monitoring, mortality, risk | 5 Comments »
Many readers of this web site may be interested in a video discussion on the Medscape web site between two relatively young urologists about the implications of the Prostate Outcomes Outcomes Study (PCOS), on which we commented a few months back. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: chronic, disease, Management, outcome, PCOS, risk | 1 Comment »
According to an article in The Sunday Times in the UK over the weekend, a well-known surgeon in the UK is claiming to have carried out “the first” radical prostatectomy on a man with no other indicator for treatment except a BRCA2 mutation and a significant family history of breast and prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Treatment | Tagged: BRCA1, BRCA2, prophylactic, risk, surgery, Treatment | 3 Comments »
Last September we asked whether the Oncotype DX test for risk of prostate cancer developed by Genomic Health was “ready for prime time”. In a media release issued earlier this week, the company said that it was. However, there are a number of unresolved issues that are likely to impact the uptake of this new test. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Uncategorized | Tagged: DX, Oncotype, risk, significant | 4 Comments »
One of the things that is most interesting about the new guidelines issued by the AUA last week (see here for original announcement) is that they seem to be gaining reasonably widespread approval — probably because they are actually (and finally) based on actual evidence as opposed to raw opinion. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: guideline, PSA, risk, screening, testing | 14 Comments »
According to an article just published on line in Prostate, taking statins before a diagnosis of prostate cancer lowers risk for prostate cancer-specific mortality (but does not lower risk for progression/recurrence of prostate cancer after first-line treatment). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: Diagnosis, mortality, risk, statin | 2 Comments »
In a paper to be presented at the annual meeting of the American Urological Association, Ehdaie et al. have shown that, among men with prostate cancer being managed on active surveillance, the number of previous biopsies is associated with significant risk of infectious complications and every previous biopsy increases the risk an infectious complication. … READ MORE …
Filed under: Uncategorized | Tagged: active surveillance, biopsy, complication, infection, risk | 4 Comments »
A podium presentation by Kingman et al. at the upcoming annual meeting of the American Urological Association (AUA) may be among the most significant to be presented at the meeting. It seriously challenges the long-held belief about the need to routinely re-biopsy men initially diagnosed with high-grade prostatic intraepithelial neoplasia (HG-PIN). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: biopsy, HG-PIN, high-grade, neoplasia, PSA, risk | Leave a Comment »
A new study just published on line in Clinical Cancer Research shows a degree of correlation between the results of tests for PCA3 and the TMRPSS2-ERG biomarker and risk for progressive disease in men on active surveillance. However, this correlation appears to be less than compelling. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: acgtive surveillance, biomarker, PCA3, risk, TMRPSS2-ERG | Leave a Comment »
A story posted yesterday on the Bloomberg News web site suggests that risk associated with severe infections caused by prostate biopsies may be starting to change how urologists carry out prostate biopsies, and even whether to do them in many cases. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: biopsy, infection, risk, sepsis | 1 Comment »
There’s been a lot of media noise today about a study just published on line in Cancer Epidemiology, Biomarkers & Prevention. The study indicates an association between obesity and future risk for a diagnosis of prostate cancer but (as we state frequently) an “association” is by no means the same as “cause and effect”. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: obesity, risk | Leave a Comment »
A new study, to published shortly on-line in Cancer, suggests that significant alterations to the “copy numbers” of the PTEN and MYC genes in men with prostate cancer are strongly associated with risk for prostate cancer-specific mortality. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: alteration, analysis, copy number, gene, mortality, MYC, PTEN, risk | 3 Comments »
A new study just published on line in the Journal of Clinical Oncology had confirmed that “BRCA1/2 mutations confer a more aggressive [prostate cancer] phenotype with a higher probability of nodal involvement and distant metastasis.” This is not a surprising finding, but it does have real implications for men with a family history of BRCA1/2 mutations. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: BRCA1, BRCA2, hereditary, mortality, risk, survival | 8 Comments »
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