The PSA screening dichotomy continues to make news

A research letter just published in the Journal of the American Medical Association this week confirms what most physicians and prostate cancer advocates were already well aware of … that the U.S. Preventive Services Task Force (USPSTF) recommendation from 2008 — that men of 75 years and older should not generally be given annual PSA [...]

The Berkshire Hathaway effect on prostate cancer management

As many readers will be aware, the Sage of Omaha, Warren Buffett, chairman and CEO of Berkshire Hathaway, announced yesterday that he has been diagnosed with prostate cancer that is “not remotely life threatening.” He does intend, however, to undergo 8 weeks of radiation therapy. Mr. Buffet is 81 years of age.

What’s new in the Journal of the Canadian Urologic Association?

The April issue of the Journal of the Canadian Urologic Association offers the interested reader access to the full texts of a small number of topical articles. None of them could be considered “game changing” in terms of current prostate cancer management today … but certainly thought-stimulating.

CNV analysis hints at hereditary susceptibilities for prostate cancer

An new article on line in the Proceedings of the National Academy of Sciences or PNAS has further extended our understanding of the genetic and inheritable factors that may predispose individual patients to higher risk for clinically significant and aggressive forms of prostate cancer

Health Affairs asks tough questions about cost, value, and medical care of men at risk for prostate cancer

One of four articles published yesterday in the journal Health Affairs is causing another major furor in the urology community. The article reports that urology practices that carry out their own pathological analysis of biopsy samples in house order more biopsy samples than practices that send samples to independent laboratories.

BMI correlates to risk for biochemical recurrence post-surgery

According to data presented on Tuesday at the American Association for Cancer Research annual meeting in Chicago, body mass index (BMI)  at the time of surgery correlates with risk for biochemical recurrence of prostate cancer after first-line treatment with radical prostatectomy.

Is combination EBRT + LDR-BT worth the risk for most patients?

Long-term data from the Radiaton Treatment Oncology Group (RTOG) 00-19 Phase II trial of external beam radiation therapy (EBRT) + low-dose-rate permanent implant brachytherapy (LDR-BT) has suggested that this type of radiation treatment is probably no more effective than either EBRT or LDR-BT alone … but does have a greater risk for long-term side effects.

Circumcision and prostate cancer risk … correlation is not cause and effect …

A study published recently by researchers based at the University of Washington reported correlation between circumcision and risk for prostate cancer … but it is important to note that (a) they were not claiming to have proven a cause and effect relationship and (b) the supposed increase in risk of 15 percent was an increase [...]

Could SRY or an SRY-like gene be at the root of risk for prostate cancer?

A new paper just published in BioEssays puts forward the hypothesis that a gene known as the SRY gene, which directs development of “maleness,” may have specific impact on behavioral and on clinical aspects of being male (e.g., aggressiveness; the so-called “flight or fight” response to stress; even some male-based neurological disorders like Parkinson’s disease).

Detecting prostate cancer with a micro-chip … well, maybe (or maybe not)

According to an article in Men’s Health News, some Italian researchers at the University of Parma have developed a chip that’s able to detect a suspected marker of aggressive prostate cancer, called sarcosine, in urine.

Antibiotic prophylaxis prior to urologic surgical conditions

In August 2011, the  American Urological Association (AUA) updated its document “Best Practice Policy Statement on Urologic Surgery Antibiotic Prophylaxis,” including information about antibiotic propylaxis prior to a transrectal biopsy.

GTx forced to stop development of Capesaris (GTx-758)

The US Food & Drug Administration (FDA) has advised GTx to stop development of GTx-758 (also known as Capesaris), its oral drug intended for the treatment of men with advanced prostate cancer, after it became apparent that there was an increase in risk for blood clots in men taking active drug compared to those being [...]

Active surveillance or immediate surgery for low-risk prostate cancer: let’s look at the math

A new study has attempted to calculate the impact of age, health status, and patient preference on the relative outcomes (and merits) of immediate surgery as compared to active surveillance for the management of low-risk prostate cancer.

Elevated cholesterol levels and risk for high-grade prostate cancer

A new report from a Scottish research team offers evidence that high plasma cholesterol levels are associated with an increased risk for a diagnosis of high-grade prostate cancer.

FDA approves Gen-Probe PCA3 test (Progensa)

According to a report today on Xconomy.com, the U.S. Food & Drug Administration has approved the Progensa® PCA3 test developed by Gen-Probe.

Follow

Get every new post delivered to your Inbox.

Join 332 other followers