Salvage surgery as second-line therapy after HIFU for localized prostate cancer

High-intensity focused ultrasound (HIFU) is approved in Canada for the treatment of localized prostate cancer. Since its approval, this form of treatment has become popular among patients seeking a potentially curative form of treatment with low risk for complications and side effects.

Preliminary results of RTOG 96-01 in progressive prostate cancer

RTOG 96-01 is a randomized, multi-center Phase III trial designed to compare bicalutamide monotherapy + salvage radiation therapy  to a placebo + salvage radiation alone in men with pT2-3N0Mo prostate cancer who have an elevated PSA after surgery.

Evaluating the need for immediate, adjuvant radiation therapy after surgery

Men with high-risk, localized prostate cancer who decide on surgery as their first-line treatment of choice are sometimes faced with the question of whether to undergo “immediate” adjuvant radiation therapy after their surgery or to do nothing and wait to see if salvage radiation therapy becomes necessary.

Immediate adjuvant radiation therapy in the pT3 patient post-surgery

In March 2009, Thompson et al. published data from the SWOG 8794 trial showing that adjuvant radiation therapy immediately post-surgery significantly improved the oncologic outcomes of men with pathologic T3N0M0 prostate cancer compared to later salvage radiation, but

Projecting outcomes of second-line (salvage) cryotherapy

One of the problems of first-line radiation therapy is how to treat patients with a rising PSA (biochemical relapse) after it becomes clear that the rise in PSA is not simply a “biochemical bounce” in the PSA.

HIFU as salvage therapy for radiation failure

One of the proposed uses for high-intensity focused ultrasound (HIFU)  has been as a treatment option for men with a rising PSA after first-line treatment with external beam radiation therapy (EBRT).

Prostate cancer news reports: Tuesday, February 2, 2010

Today’s news reports address: Daily fat intake and risk for prostate cancer Salvage RALP as a treatment for patients in biochemical relapse after first-line EBRT Phase II data on fenretinide as a possible treatment for HRPC

Prostate cancer news reports: December 8, 2009

In today’s news reports we comment on articles dealing with: The declining rate of prostate cancer mortality in the USA Managing prostate cancer in the elderly Re-validation of the Partin tables RALP as salvage surgery for radiation-resistant patients

Long-term follow-up of patients needing post-RP salvage radiation

A long-term study from the Mayo Clinic reports a low incidence of complications (other than erectile dysfunction) following salvage radiotherapy for men with prostate cancer recurrence after an initial radical prostatectomy.

How early can PSA doubling times tell what?

A new study from a group at Duke University has attempted to assess whether data based on PSA doubling times in men with PSA levels up to 0.2 ng/ml can be used as effectively to make early treatment decisions for men with a rising PSA after first-line therapy as can PSA doubling times for men [...]

Prostate cancer news reports: Tuesday, July 7, 2009

In today’s news reports we address new data on: The possible association between PSA levels and SNPs Patient age at diagnosis and prostate cancer outcomes Revalidation of the Stephenson nomogram for outcomes after salvage radiation therapy Failure to follow best practices for radiation of bony metastases

Prostate cancer news reports: Saturday, June 27, 2009

Today’s news reports deal with such items as: Genomic testing for prostate cancer and the value of specific SNPs What do pre-treatment MRI/MRSI tests and molecular profiling add to prognostic significance? Quality of life following salvage brachytherapy

Radiotherapy + ADT following radical prostatectomy

A Canadian group has just added a little more to our knowledge about the role of neoadjuvant hormone therapy in association with radiotherapy after first-line radical prostatectomy (RP).

AUA report and update no. 12: Friday, May 1, 2009

And still the stream of information continues, with  reports about frequency of PSA testing, nerve-sparing in men with Gleason 6 disease, and HIFU as a form of salvage therapy after first-line radiation:

The Wednesday news reports: January 7, 2009

Wednesday’s news reports include  items on: The occurrence of “clinically insignificant” prostate cancer in an autopsy series The value of a patient decision aid in management of localized prostate cancer The clinical value of the 2005 International Society of Urologic Pathology Gleason Grading Consensus score (ISUP GS)  Outcomes of radical prostatectomy for prostate cancer discovered [...]

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