Supervised exercise and prevention of ADT-related side effects

A small, randomized trial in a group of 60+ Australian patients has demonstrated that a supervised exercise program started at the same time as initiation of androgen deprivation therapy (ADT) can have multiple beneficial results, including (at least temporary) avoidance of known side effects of ADT. … READ MORE …

Follow-up to earlier commentary on the Michigan Prostate Cancer Survivor study

Late last week we commented briefly on a paper (by Darwish-Yassine et al.) entitled “Evaluating long-term patient centered outcomes following prostate cancer treatment: findings from the Michigan Prostate Cancer Survivor study.” … READ MORE …

Long-term quality of life and survivorship issues for prostate cancer patients

There are very few really good data available on the long-term follow-up of men diagnosed and treated for prostate cancer outside a select group of specialized prostate cancer centers (with the notable exception of the data collected as part of the CaPSURE initiative). … READ MORE …

Are Canadian patients told enough about side effects of LHRH agonist therapy?

According to a survey of 75 Canadian physicians, there is a degree of disagreement among these physicians about what they should tell their patients about the side effects known to be associated with the use of LHRH agonists as a form of androgen deprivation therapy (ADT). … READ MORE …

HIFU outcomes in Germany after an average of 8 years of follow-up

Researchers at the University of Regensburg in Germany have just reported progression-free survival data from their 14-year experience of using high-intensity focused ultrasound (HIFU) in the treatment of localized prostate cancer. This research group was one of the first to start testing the use of HIFU in the treatment of prostate cancer. … READ MORE …

Managing the side effects of ADT — a new review

According to a new analysis and review of recent, published data, the “numerous well recognized adverse effects” of androgen deprivation therapy (ADT) include “vasomotor flushing, loss of libido and impotence, fatigue, gynecomastia, anemia, osteoporosis and metabolic complications, as well as effects on cardiovascular health and bone density.” … READ MORE …

Delaying surgery for localized prostate cancer … what’s the downside?

A paper published in June this year in the Journal of Sexual Medicine suggests that delaying radical prostatectomy (RP) as a first-line treatment for localized prostate cancer has no significant effects on post-surgical pathology or mortality but may lead to higher risk for incontinence and erectile dysfunction. … READ MORE …

Risks associated with implantation of “fiducial markers” before radiation therapy

It is becoming commonplace for men who are going to get external beam radiotherapy to treat their prostate cancer to have some form of “fiducial marker” (often tiny gold rods or balls) inserted into their prostates under transrectal ultrasound guidance to help ensure that the radiotherapy can be administered with the greatest possible accuracy. … READ MORE …

Acute and mid-term side effects of high-dose, image-guided IMRT in first-line treatment of localized prostate cancer

Two recent papers have reported data relevant to the application of high-dose, image-guided, intensity-modulated forms of radiation therapy (IGRT/IMRT) in the first-line treatment of men with localized prostate cancer. … READ MORE …

A new way to look at side effects of first-line prostate cancer treatment

Academic research into the side effects of different treatments for localized prostate cancer have long been hampered by the lack of consistently used criteria for the assessment of those side effects at baseline and at defined time-periods post-treatment. … READ MORE …

The role of exercise in prostate cancer management

Prostate cancer patients in general, but most especially men receiving androgen deprivation therapy (ADT), experience symptoms  and side effects of treatment that make it difficult to maintain their independence and quality of life. A recent review states that exercise may offset many of the side effects of ADT as well as those of the cancer itself. … READ MORE …

Treatment decision regret after radical prostatectomy

Prior studies have looked at the question of patient regret after election of specific types of treatment for localized prostate cancer. Unsurprisingly, this effect is not confined to patients in the USA, and a new study from Taiwan indicates that patient regret may be as high as 31 percent after radical prostatectomy (RP). … READ MORE …

Side effects of surgery among patients diagnosed in the Göteborg screening trial

In July this year, we commented on the 14-year mortality data published by Hugosson et al. from the randomized, population-based, prostate cancer screening trial initiated in Göteborg, Sweden, in 1995. … READ MORE …

Slightly fewer (severe) complications after IMRT compared to CRT

According to a media release from the University of Pennsylvania Health System, (and another from the American Society of Radiation Oncology [ASTRO]), intensity-modulated radiation therapy (IMRT) is associated with fewer complications than traditional, three-dimensional conformal radiation therapy (3D-CRT) in the treatment of non-metastatic prostate cancer. … READ MORE …

Report provides final results of the TROPIC trial of cabazitaxel

Cabazitaxel (Jevtana®) has recently been approved in the USA for the treatment of men with castration-resistant prostate cancer who have progressive disease following treatment with standard first-line chemotherapy (docetaxel + prednisone). … READ MORE …

Follow

Get every new post delivered to your Inbox.

Join 1,113 other followers