Survival of prostate cancer patients diagnosed with M1 disease in the modern era

Back in the late 1980s and early 1990s, the projected survival time for a man diagnosed with evident metastatic prostate cancer (then called D2 disease and now known as TxNxM1 disease) was about 18 to 36 months. Has that really changed in the past 25 years? … READ MORE …

Second-line therapy for progressive, high-risk prostate cancer: time for a STAMPEDE-like trial?

Let’s say you are 58 years of age, in apparently excellent health for your age, when you get diagnosed with high-risk prostate cancer, based on a Gleason score of 4 + 4 = 8, a PSA level of 3.7, and a clinical stage of T1c, with 4/12 biopsy cores positive for cancer. … READ MORE …

An update to the STAMPEDE trial in the UK, Switzerland

We have previously discussed, in some detail,  the multi-arm, ongoing STAMPEDE trial in the UK and Switzerland, which is looking — in a comparative manner — at a whole series of treatment processes among men with advanced forms of prostate cancer. … READ MORE …

Baseline data from the control arm of the STAMPEDE trial

One of the more interesting sets of data on metastatic prostate cancer to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago this year will be some of the very earliest data from the STAMPEDE trial, which we have discussed in some detail in an earlier post. … READ MORE …

STAMPEDE: an important trial in the management of advanced prostate cancer

Most of the time, when we talk about clinical trials of drugs (or other treatments) for prostate cancer, we are talking about trials in which new treatment X is compared to standard (current) treatment Y or, if there is no standard, new treatment Z is compared to a placebo (a benign, “dummy” substitute). … READ MORE …

Tuesday’s news update: November 18, 2008

Today’s news items include information about:

  • The potential of spinal MRI in diagnosis of men at risk for spinal metastasis
  • A review of data on use of PDE5 inhibitors to manage post-surgical erectile dysfunction
  • A “flare” phenomenom associated with docetaxel therapy in some patients
  • The current status of the STAMPEDE clinical trial … READ MORE …
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