Survey suggests high level of long-term side effects after treatment for prostate cancer

According to new data presented at the Frontiers in Cancer Prevention Research meeting ongoing this week in Boston, MA, some 70 percent of prostate cancer patients participating in a survey in Michigan reported long-term, treatment-related, adverse effects after first-line treatment with surgery or radiation therapy.

Is surgery appropriate for men with high-risk prostate cancer?

An article by Schmitges et al., originally published in Therapeutic Advances in Urology in August this year, has just been reproduced on the Medscape Oncology web site, where it is available in complete form.

Intraoperative, tumor-specific fluorescence imaging — will it work in prostate cancer?

A report just published on line in Nature Medicine describes the first use of intraoperative, tumor-specific fluorescence imaging to highlight the precise position of small groups of cancer cells in women with ovarian cancer, thereby allowing the surgeon to carefully excise such small groups of cells.

A new way to look at side effects of first-line prostate cancer treatment

Academic research into the side effects of different treatments for localized prostate cancer have long been hampered by the lack of consistently used criteria for the assessment of those side effects at baseline and at defined time-periods post-treatment.

Incidence of climacturia “surprising” to one leading surgeon

It is sometimes amazing how little some physicians appear to understand about the side effects of the treatments that they give to their patients! If these were really rare side effects it might be understandable, but the one we shall discuss below is far from rare …

Utilization of standard treatments for localized prostate cancer by Medicare beneficiaries

In a new paper just published on-line in the Journal of Urology, Kapoor et al. have provided data on trends in the utilization of various major types of treatment for the management of localized prostate cancer among Medicare beneficiaries in the USA between 2006 and 2008.

VED + taldalafil helps with return of erectile function post-surgery vs. taldalafil alone

A very small (pilot scale), randomized, clinical trial has provided some evidence that combining the use of a vacuum erection device (VED) with taldalafil (Cialis) drug therapy after bilateral, nerve-sparing robot-assisted laparoscopic prostatectomy (BNS-RALP) can improve the probability of return of erectile function post-surgery.

Patients’ decisions, patients’ expectations, and surgery for localized prostate cancer

Two articles and an associated editorial, currently in press in the Journal of Urology, offer insight into the pre-treatment expectations and the post-treatment realities of men who decide to have surgical treatment for localized prostate cancer.

Outcomes after surgery for spinal cord compression among men with metastatic prostate cancer

Spinal cord compression is a relatively common consequence of advanced, metastatic prostate cancer. Treatment has historically involved reconstructive surgery to relieve the compression and stabilize the spine.

CAPRA-S scores and projection of prostate cancer recurrence post-surgery

The University of California, San Francisco (UCSF) Cancer of the Prostate Risk Assessment (CAPRA) score was initially introduced in 2005 and validated in 2006 as a pre-treatment tool that could be used to assess risk for prostate cancer recurrence after first-line treatment.

Duloxetine in treatment of mild to moderate post-surgical incontinence

Let us be clear up front … Duloxetine (Cymbalta®) has not been approved anywhere in the world that we are aware of as a treatment for post-surgical incontinence in men treated for prostate cancer, and there has never been a large, randomized, double-blind Phase III trial to try to demonstrate such activity.

How surgeons and patients think about post-surgical incontinence

We are coming to the conclusion that there is a deep divide between how some surgeons think about post-surgical incontinence following radical prostatectomy for their prostate cancer and how patients may think about such incontinence when defined by exactly the same set of clinical symptoms and quality of life issues.

The initial results of the PIVOT study

So Dr. Timothy Wilt presented the initial results of the Prostate Cancer Intervention Versus Observation Trial (PIVOT) at the annual meeting of the AUA yesterday morning. They showed what many of us may have been expecting.

Adjuvant ADT after surgery in men with high-risk prostate cancer

Back in June 2010, we reported on the initial results of SWOG 9921 — a trial that randomized 983 men with high-risk features at prostatectomy to receive adjuvant therapy with androgen deprivation (ADT) alone or in combination with mitoxantrone chemotherapy.

“Reverse stage shift” at major tertiary prostate cancer center since 2000

Exactly how some of the major, tertiary, specialized prostate cancer centers think about the management of prostate cancer over time needs to be taken into account in evaluation of the data being published by those centers.

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