Who needs aggressive treatment after initial radiation … and who does not?

A new report in Lancet Oncology offers guidance on which patients with prostate cancer who are initially treated with radiotherapy and 6 months of neoadjuvant androgen deprivation therapy (ADT) are at relatively high and relatively low levels of risk for prostate cancer-specific mortality.

Prostate cancer news reports: Wednesday, September 23, 2009

Today’s news reports cover items on: Extent and number of biopsy cores and eligibility for active surveillance Intermittent vs. complete androgen deprivation Hormone therapy and risk for cardiovascular disease and death Surrogate markets for disease progression in men with CRPC

Using PSA progression to predict survival in clinical trials

Because it takes so long for men with even advanced prostate cancer to progress through to death from any cause, there has been extensive effort over the years to define “surrogate” endpoints for prostate cancer-specific and overall survival in prostate cancer clinical trials.

Potential surrogate endpoints for prostate cancer-specific survival

There have been several attempts to clearly define surrogate endpoints for prostate cancer-specific survival that could be used to shorten the length of clinical trials investigating the merits of specific forms of treatment for prostate cancer. A new analysis of data from the 1,554-patient RTOG 92-02 trial has further explored two such possibilities.

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