Full data report from the ALSYMPCA trial of radium-223 presented

According to a company media release, the full results of the ALSYMPCA  trial were presented Saturday at the European Multidisciplinary Cancer Congress (EMCC). This is the trial of the injectable radioactive agent radium-223 chloride (Alpharadin®) in men with symptomatic, metastatic, castration-resistant prostate cancer (mCRPC).

Oncogenex makes SATURN trial of custirsen (OGX-011) more accessible

The Phase III SATURN clinical trial of OGX-011 in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) after initial chemotherapy with docetaxel + prednisone required men to be randomized to either docetaxel + prednisone + OGX-011 or to docetaxel + prednisone + a placebo.

Prostate cancer mortality rates in Denmark: 1998 to 2009

As we have noted several times before, databases in selected European nations (most particularly the Scandinavian countries) allow for the possibility of highly accurate analyses of  information on the diagnosis, management, and outcomes of prostate cancer (and other disorders) over time based on data from very large numbers of people.

Approval of denosumab for extension of metastasis-free survival in the USA?

According to a media release from Amgen earlier today, the U.S. Food & Drug Administration (FDA) has indicated that a decision will be made by April 26, 2012 about the requested expansion of the indication for denosumab (Xgeva®) to include the prevention of bone metastases in men with non-metastatic, castration-resistant prostate cancer.

Amgen requests expanded indication for denosumab

As expected (and as previously discussed on this site), Amgen has submitted a supplemental Biologics Licensing Application (sBLA) for denosumab (Xgeva®) for the prevention or the delay of the spread of prostate cancer to bone in men with castrate-resistant prostate cancer (CRPC).

Alpharadin shows 2.8-month survival benefit in mCRPC

The investigational radioisotope radium-233 chloride (Alpharadin) has shown a small but clinically significant overall survival benefit in the treatment of men with symptomatic, metastatic, castration-resistant prostate cancer (mCRPC).

Survival and CTC data from the abiraterone acterate pivotal trial

As we have previously reported, the latest analysis of survival data from the pivotal Phase III trial of abiraterone acetate + predisone has shown a slight improvement in the survival benefit for patients treated with abiraterone (Zytiga™).

Impact of abiraterone prior to chemotherapy — maybe not 4 years, but …

A story on the Bloomberg.com web site gives information about a patient with castration-resistant prostate cancer (CRPC) who has had a zero-level PSA for 40 months since starting on a clinical trial of abiraterone actetate in early 2008.

Impact of denosumab on bone metastasis-free survival

A presentation at the American Urological Association annual meeting in Washington a few days ago provided data that treatment with denosumab (Xgeva) delayed the onset of bone metastasis by 4.2 months compared to treatment with a placebo in men with high-risk, non-metastatic, castration-resistant prostate cancer.

What’s hot at the AUA annual meeting (Monday)?

With many hundreds of prostate cancer-specific posters and oral presentations each day at the meeting, even trying to pick the sessions one wants to cover can be a challenge, but some general trends are becoming evident.

FDA approval of abiraterone: some interesting notes

We have already noted the FDA’s approval of abiraterone acetate. However, there are some interesting details that are worthy of note.

Radiation therapy for men with locally advanced prostate cancer: a meta-analysis

Data from a meta-analysis of four, large, randomized, clinical trials of radiation therapy for locally advanced forms of prostate cancer suggests that radiation treatment lowers risk for metastasis and prostate cancer-specific mortality (PCSM), but that patient age at the time of treatment is a key factor too.

6 months of neoadjuvant ADT doubles survival when given with radiation therapy

A new article in Lancet Oncology has reported that a mere 6 months of neoadjuvant hormone therapy, when combined with radiation therapy, cuts the risk of dying from locally advanced prostate cancer by 50 percent compared to radiation alone at 10 years of follow-up.

Comorbidity, treatment, and mortality among Swedish prostate cancer patients

A clear appreciation of the associations between life expectancy, comorbid conditions (e.g., diabetes, obesity, cardiovascular disorders), and mortality is critically important to treatment decisions for all patients with prostate cancer, but most especially the newly diagnosed, low-risk patient.

What you believe may not be good for you

A study by researchers at the University of Miami and Yale School of Medicine suggests there may be an association between patients’ beliefs about the potential curability of prostate cancer and their overall, long-term survival.

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