Interpreting the data from the S9346/INT-0162 trial in hormone-sensitive, metastatic disease

We have already reported data, presented by Dr. Maha Hussain yesterday, that appear to show that — at least in men with clearly metastatic prostate cancer — continuous and complete androgen deprivation (CAD) extends survival significantly better than intermittent androgen deprivation (IAD). … READ MORE …

IAD vs. CAD in men with hormone-sensitive, metastatic prostate cancer

Today at the ASCO annual meeting, Maha Hussein presented the results a long-term, international, randomized trial of intermittent androgen deprivation (IAD) versus continuous androgen deprivation (CAD) in men with hormone-sensitive, metastatic prostate cancer. … READ MORE …

Abiraterone acetate in chemotherapy-naive mCRPC — Phase III trial outcome

This morning, at the ASCO annual meeting, Dr. Charles Ryan will present the full interim results of COU-AA-302, the randomized, Phase III study of abiraterone acetate in chemotherapy-naive patients with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Death of al Megrahi — but was it of prostate cancer at all?

Acccording to an article on the Medscape web site today, the convicted “Lockerbie bomber,” Abdelbaset al Megrahi, finally died on Sunday, 2 years and 9 months after his release from a Scottish prison on compassionate grounds because he was close to dying of terminal prostate cancer. … READ MORE …

ADT + radiotherapy in the treatment of high-risk prostate cancer; today’s “best practices”

A new review published recently in the British Journal of Cancer addresses appropriate current practice regarding the use of neoadjuvant and adjuvant androgen deprivation therapy (ADT) in combination with radiation therapy in the management of patients with high-risk localized and locally advanced forms of prostate cancer. … READ MORE …

Outcomes after surgery for low-risk disease in men 65 years and older at a major prostate cancer center

Data from the extensive series of patients with clinically localized prostate cancer treated by radical prostatectomy at Johns Hopkins over the past 30 years has shown that men > 65 years of age with low-risk disease had excellent survival after surgery, … READ MORE …

VHA cancer management quality study does NOT include prostate cancer

A new study in the Journal of Clinical Oncology has provided data regarding the survival of men of 65 years and older diagnosed with and treated for selected cancers within the Veterans Health Administration (VHA) system as compared to similar men treated under the fee-for-service Medicare system. This study has received a lot of media coverage. … READ MORE …

No survival benefit to screening in Spanish arm of ERSPC trial

A newly published article has concluded that, among the 4,000+ men enrolled in the Spanish cohort of the European Randomized Study of Screening for Prostate Cancer (ERSPC), there were no differences in overall or prostate cancer-specific mortality at 15 years of follow-up. … READ MORE …

Survival after a diagnosis of AJCC Stage IV prostate cancer

For many men, a diagnosis of prostate cancer of any stage or grade — even of the lowest level of risk — is hard to deal with. If they have progressive disease after first-line therapy, it may appear to be an overwhelming issue. … READ MORE …

Small, Phase I combo trial suggests 3-year overall survival in men with mCRPC

A media release issued earlier today by Barvarian Nordic (the developer of Prostvac®) gives us an inkling of where we may be headed in the development of combination therapies for the management of late stage (and maybe even earlier stage) forms of prostate cancer. … READ MORE …

Relative 10-year survival after surgery, EBRT, or brachytherapy in the PSA era

A new study on relative rates of survival at 10 years, just published on line, is probably going to get differing reactions from patients and from physicians depending on their individual points of view. … READ MORE …

Trip’s trip … 10 years of battling metastatic prostate cancer

In 2001, when he was just 49 years old, Ward “Trip” Casscells experienced lower back pain that became progressively worse. Then, he felt a lump in his abdominal area. He had an aggressive, metastatic prostate cancer. … READ MORE …

Denosumab and delay of onset of bone metastasis

The full data on the use of denosumab to delay the onset of bone metastasis in men with high-risk, progressive, non-metastatic, castration-resistant prostate cancer (CRPC) were published on line yesterday in The Lancet. We originally reported the results of this trial as presented at the annual meeting of the American Urological Association (AUA) in May this year. … READ MORE …

Are changes in PSA kinetics potentially indicative of metastasis-free survival?

Researchers at Johns Hopkins have provided data to support the hypothesis that, in men being treated with novel, non-hormonal agents for non-metastatic, non-castrate, biochemically recurrent prostate cancer after first-line therapy, changes in PSA kinetics may be indicative of metastasis-free survival. … READ MORE …

Poor science underlies the USPSTF recommendation about PSA-based screening

Whatever we may think individually about the recent decision by the U.S. Preventive Services Task Force to recommend against the use of PSA testing as a means of “screening” for risk of prostate cancer, we would be wise to understand that at the heart of this decision is poor science. … READ MORE …

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