Genetics, genomics, and improvements in the management of prostate cancer

Over the past few years we have seen a great deal of discussion of this or that new gene or single nucleotide polymorphism (SNP) or other set of genomic data and the potential of such information to improve the diagnosis or the prognosis of prostate cancer.

So what IS the point of “screening” for prostate cancer?

A media release issued yesterday by Dr. David Samadi, a specialist in minimally invasive surgery at Mount Sinai Medical Center in New York City, has questioned whether the purpose of prostate cancer screening is to save lives or to prevent progressive prostate cancer.

Post-op pelvic anatomy after RALP and open surgery

According to an article by Hirsch et al. in the inaugural issue of Practical Radiation Oncology (a new journal for radiation oncologists and their staff), there are some small but significant post-operative differences in pelvic anatomy between patients who undergo robot-assisted laparoscopic prostatectomy (RALP) as opposed to standard, open forms of radical prostatectomy.

Prostate cancer treatment in southwestern Georgia: race and a rural environment

A new study just published in Urology seems to confirm facts that have previously been identified in earlier studies of how men elect to get treated for localized prostate cancer in parts of the USA with a high proportion of African American residents and relatively low income levels.

Are we (still) over-treating older men with localized prostate cancer?

There is good reason to believe that a very high percentage of older men — particularly those over 75 years with low-risk prostate cancer who have a life expectancy of 10 years or less — will get little to no clinical or survival benefit from active therapeutic intervention (although they should clearly be carefully monitored [...]

Physician influence on decision to select active surveillance

A small study from the University of Miami has confirmed the unsurprising but important information that patients are heavily influenced by physicians in their decision to elect (or not elect) active surveillance (AS) as a management option for low-risk prostate cancer.

Comorbidity, treatment, and mortality among Swedish prostate cancer patients

A clear appreciation of the associations between life expectancy, comorbid conditions (e.g., diabetes, obesity, cardiovascular disorders), and mortality is critically important to treatment decisions for all patients with prostate cancer, but most especially the newly diagnosed, low-risk patient.

Five questions one newly diagnosed patient wanted answers to

Jeffrey Foster was diagnosed with early stage, low-risk prostate cancer in 2009. Like a lot of smart men, he realized quickly that he needed answers to a whole bunch of questions. Apparently he is still waiting for some of those answers, because

ACR and ASTRO issue new guideline on brachytherapy

The American College of Radiology (ACR) and the American Society for Radiation Oncology (ASTRO) have jointly issued a new guidance document on the treatment of prostate cancer with permanent radioactive “seed” implants inserted through the perineum.

Consumer Reports on first-line management of prostate cancer

There is an interesting summary of the major, first-line management options for localized prostate cancer in today’s Washington Post. It has been prepared by the Consumer’s Union (publisher of Consumer Reports) as part of their Consumer Reports Insights series.

Why men choose specific first-line types of management for localized prostate cancer

The need for patients diagnosed with early stage prostate cancer to be highly involved in the decision as to which form of management they wish to be given is well understood. However, there has been a relative dearth of data on why patients actually make their individual decisions.

International survey on men’s sexual activity post-treatment

The Australian Research Centre in Sex, Health and Society at La Trobe University, Melbourne, Australia is conducting an international survey of men’s experiences of sexual activity following treatment for prostate cancer.

The management of high- and intermediate-risk prostate cancer in elderly males

Overall life expectancy of men in the US continues to rise. As a consequence, the way we treated localized prostate cancer in men of ≥ 70 years of age in 1990 will probably not be relevant or appropriate to the way we need to treat such men in 2020 (or perhaps even today).

Age, treatment, and outcomes for men with high-risk prostate cancer

A new article just published on-line in the Journal of Clinical Oncology is entitled “Impact of age at diagnosis on prostate cancer treatment and survival.”

Socioeconomic status and outcomes after prostate cancer treatment

It has long been recognized that socioeconomic status holds a direct relationship to quality of outcome in cancer treatment. In other words, the more educated and affluent among us can afford — and know how to gain access to — higher quality care than the less educated and less affluent.

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