In Gleason grades 1 and 2 the cancer cells closely resemble normal prostate cells. They are the least important grades because they occur infrequently in the general population and because they confer a prognostic benefit which is only slightly better than grade 3.
Both of these grades are composed by mass; in grade 2 they are more loosely aggregated, and some glands wander into (invade) the surrounding muscle (stroma).
Figure 2: Grade 1 (left) and grade 2 (right) prostate adenocarcinoma. Both have pale cells and well formed, separate glands with lumens. Grade 1 is more compact (less invasive) than grade 2.
Illustration courtesy of the late John E. McNeal, MD,
Department of Urology, Stanford University School of Medicine.
Department of Urology, Stanford University School of Medicine.
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